Sustained release hGH microsphere formulation produced by a novel supercritical fluid technology: In vivo studies

Novel sustained release formulations of hGH prepared by supercritical fluid processing of PLGA/PLA (the CriticalMix™ process) were produced in the form of microparticles for subcutaneous injection. The basis of the process is that PLGA/PLA polymers liquefy when exposed to supercritical CO 2, thereby...

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Veröffentlicht in:	Journal of controlled release 2010-01, Vol.141 (2), p.153-160
Hauptverfasser:	Jordan, F., Naylor, A., Kelly, C.A., Howdle, S.M., Lewis, A., Illum, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Availability Biomarkers - blood Chemistry, Pharmaceutical Chromatography, Supercritical Fluid Cynomolgus Delayed-Action Preparations Drug Carriers Drug Compounding General pharmacology hGH Human Growth Hormone - administration & dosage Human Growth Hormone - blood Human Growth Hormone - chemistry Human Growth Hormone - pharmacokinetics Injections, Intravenous Injections, Subcutaneous Insulin-Like Growth Factor I - metabolism Lactic Acid - chemistry Macaca fascicularis Male Medical sciences Microparticles Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLGA Polyesters - chemistry Polyglycolic Acid - chemistry Rats Rats, Sprague-Dawley Solubility Supercritical fluid Surface Properties Sustained release formulation Technology, Pharmaceutical - methods
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