Bovine plasma beta-mannosidase activity and its potential use for beta-mannosidosis carrier detection
Department of Pathology, Michigan State University, East Lansing 48824. Plasma beta-mannosidase activities were determined for Salers cattle from 8 herds as an evaluation of this method for detection of beta-mannosidosis heterozygotes. Several biological factors, such as age, gender, herd, and risk...
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| Veröffentlicht in: | Journal of veterinary diagnostic investigation 1992-10, Vol.4 (4), p.434-440 |
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| container_title | Journal of veterinary diagnostic investigation |
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| creator | Cavanagh, KT Jones, MZ Abbitt, B Skinner, R |
| description | Department of Pathology, Michigan State University, East Lansing 48824.
Plasma beta-mannosidase activities were determined for Salers cattle from 8 herds as an evaluation of this method for detection of beta-mannosidosis heterozygotes. Several biological factors, such as age, gender, herd, and risk of being a beta-mannosidosis carrier, were considered in this study. The mean enzyme activity for obligate heterozygotes (n = 8) was 55 U/ml (range = 43-65 U/ml), which was 59% of the mean enzyme activity for cattle that were low risk for being a carrier. These data indicate that bovine beta-mannosidosis is characterized by a gene dosage effect. The analytical and biological variation of plasma beta-mannosidase activity that was observed necessitates limiting the test to adult fullblood/purebred Salers cattle within a herd. Plasma beta-mannosidase analysis provides important information for intraherd selection of Salers cattle that are heterozygous for beta-mannosidosis. |
| doi_str_mv | 10.1177/104063879200400412 |
| format | Article |
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Plasma beta-mannosidase activities were determined for Salers cattle from 8 herds as an evaluation of this method for detection of beta-mannosidosis heterozygotes. Several biological factors, such as age, gender, herd, and risk of being a beta-mannosidosis carrier, were considered in this study. The mean enzyme activity for obligate heterozygotes (n = 8) was 55 U/ml (range = 43-65 U/ml), which was 59% of the mean enzyme activity for cattle that were low risk for being a carrier. These data indicate that bovine beta-mannosidosis is characterized by a gene dosage effect. The analytical and biological variation of plasma beta-mannosidase activity that was observed necessitates limiting the test to adult fullblood/purebred Salers cattle within a herd. Plasma beta-mannosidase analysis provides important information for intraherd selection of Salers cattle that are heterozygous for beta-mannosidosis.</description><identifier>ISSN: 1040-6387</identifier><identifier>EISSN: 1943-4936</identifier><identifier>DOI: 10.1177/104063879200400412</identifier><identifier>PMID: 1457547</identifier><language>eng</language><publisher>Los Angeles, CA: J Vet Diagn Invest</publisher><subject>Aging ; alpha-Mannosidosis - genetics ; alpha-Mannosidosis - veterinary ; Analysis of Variance ; Animals ; beta-Mannosidase ; Cattle - abnormalities ; Cattle - blood ; Female ; Genetic Carrier Screening - methods ; Male ; Mannosidases - blood ; Reproducibility of Results</subject><ispartof>Journal of veterinary diagnostic investigation, 1992-10, Vol.4 (4), p.434-440</ispartof><rights>1992 American Association of Veterinary Laboratory Diagnosticians</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-cecb3729a79f415e31e0767f9ed0fa5f3c79b6d7d8b8d2bfe227148dd15c0f803</citedby><cites>FETCH-LOGICAL-c412t-cecb3729a79f415e31e0767f9ed0fa5f3c79b6d7d8b8d2bfe227148dd15c0f803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1457547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cavanagh, KT</creatorcontrib><creatorcontrib>Jones, MZ</creatorcontrib><creatorcontrib>Abbitt, B</creatorcontrib><creatorcontrib>Skinner, R</creatorcontrib><title>Bovine plasma beta-mannosidase activity and its potential use for beta-mannosidosis carrier detection</title><title>Journal of veterinary diagnostic investigation</title><addtitle>J Vet Diagn Invest</addtitle><description>Department of Pathology, Michigan State University, East Lansing 48824.
Plasma beta-mannosidase activities were determined for Salers cattle from 8 herds as an evaluation of this method for detection of beta-mannosidosis heterozygotes. Several biological factors, such as age, gender, herd, and risk of being a beta-mannosidosis carrier, were considered in this study. The mean enzyme activity for obligate heterozygotes (n = 8) was 55 U/ml (range = 43-65 U/ml), which was 59% of the mean enzyme activity for cattle that were low risk for being a carrier. These data indicate that bovine beta-mannosidosis is characterized by a gene dosage effect. The analytical and biological variation of plasma beta-mannosidase activity that was observed necessitates limiting the test to adult fullblood/purebred Salers cattle within a herd. Plasma beta-mannosidase analysis provides important information for intraherd selection of Salers cattle that are heterozygous for beta-mannosidosis.</description><subject>Aging</subject><subject>alpha-Mannosidosis - genetics</subject><subject>alpha-Mannosidosis - veterinary</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>beta-Mannosidase</subject><subject>Cattle - abnormalities</subject><subject>Cattle - blood</subject><subject>Female</subject><subject>Genetic Carrier Screening - methods</subject><subject>Male</subject><subject>Mannosidases - blood</subject><subject>Reproducibility of Results</subject><issn>1040-6387</issn><issn>1943-4936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UUtLJDEQDouLj9E_sCDkorfWvHrSfdTBVUHwsnsO6aSiGbo7Y5IemX-_GVpYRJAQUtT3oOoLQr8ouaJUymtKBFnyRraMlIoIyn6gY9oKXomWLw9KXdrVnnGETlJaE1KzWtJDdEhFLWshjxHchq0fAW96nQaNO8i6GvQ4huStToC1yX7r8w7r0WKfE96EDGP2usdTgV2InzXlJmx0jB4itpCh6MN4in463Sc4-3gX6O_vuz-rh-rp-f5xdfNUmTJ7rgyYjkvWatk6QWvgFIhcSteCJU7XjhvZdksrbdM1lnUOGJNUNNbS2hDXEL5Al7PvJoa3CVJWg08G-l6PEKakJOeSNGJPZDPRxJBSBKc20Q867hQlap-t-pptEZ1_uE_dAPa_ZA6z4NcznvQLqHWY4liW_d7xYla8-pfXdx9BlU_o--LP1HprvVDlcMH_AS3zkG8</recordid><startdate>19921001</startdate><enddate>19921001</enddate><creator>Cavanagh, KT</creator><creator>Jones, MZ</creator><creator>Abbitt, B</creator><creator>Skinner, R</creator><general>J Vet Diagn Invest</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19921001</creationdate><title>Bovine plasma beta-mannosidase activity and its potential use for beta-mannosidosis carrier detection</title><author>Cavanagh, KT ; Jones, MZ ; Abbitt, B ; Skinner, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-cecb3729a79f415e31e0767f9ed0fa5f3c79b6d7d8b8d2bfe227148dd15c0f803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aging</topic><topic>alpha-Mannosidosis - genetics</topic><topic>alpha-Mannosidosis - veterinary</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>beta-Mannosidase</topic><topic>Cattle - abnormalities</topic><topic>Cattle - blood</topic><topic>Female</topic><topic>Genetic Carrier Screening - methods</topic><topic>Male</topic><topic>Mannosidases - blood</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cavanagh, KT</creatorcontrib><creatorcontrib>Jones, MZ</creatorcontrib><creatorcontrib>Abbitt, B</creatorcontrib><creatorcontrib>Skinner, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary diagnostic investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cavanagh, KT</au><au>Jones, MZ</au><au>Abbitt, B</au><au>Skinner, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bovine plasma beta-mannosidase activity and its potential use for beta-mannosidosis carrier detection</atitle><jtitle>Journal of veterinary diagnostic investigation</jtitle><addtitle>J Vet Diagn Invest</addtitle><date>1992-10-01</date><risdate>1992</risdate><volume>4</volume><issue>4</issue><spage>434</spage><epage>440</epage><pages>434-440</pages><issn>1040-6387</issn><eissn>1943-4936</eissn><abstract>Department of Pathology, Michigan State University, East Lansing 48824.
Plasma beta-mannosidase activities were determined for Salers cattle from 8 herds as an evaluation of this method for detection of beta-mannosidosis heterozygotes. Several biological factors, such as age, gender, herd, and risk of being a beta-mannosidosis carrier, were considered in this study. The mean enzyme activity for obligate heterozygotes (n = 8) was 55 U/ml (range = 43-65 U/ml), which was 59% of the mean enzyme activity for cattle that were low risk for being a carrier. These data indicate that bovine beta-mannosidosis is characterized by a gene dosage effect. The analytical and biological variation of plasma beta-mannosidase activity that was observed necessitates limiting the test to adult fullblood/purebred Salers cattle within a herd. Plasma beta-mannosidase analysis provides important information for intraherd selection of Salers cattle that are heterozygous for beta-mannosidosis.</abstract><cop>Los Angeles, CA</cop><pub>J Vet Diagn Invest</pub><pmid>1457547</pmid><doi>10.1177/104063879200400412</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1040-6387 |
| ispartof | Journal of veterinary diagnostic investigation, 1992-10, Vol.4 (4), p.434-440 |
| issn | 1040-6387 1943-4936 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aging alpha-Mannosidosis - genetics alpha-Mannosidosis - veterinary Analysis of Variance Animals beta-Mannosidase Cattle - abnormalities Cattle - blood Female Genetic Carrier Screening - methods Male Mannosidases - blood Reproducibility of Results |
| title | Bovine plasma beta-mannosidase activity and its potential use for beta-mannosidosis carrier detection |
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