Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy

Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) is one of several members of the TNF gene superfamily that induce apoptosis through engagement of death receptors. Apo2L/TRAIL is unusual as compared to any other cytokine as it interacts with a complex system...

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Veröffentlicht in:	Cytokine & growth factor reviews 2003-06, Vol.14 (3), p.337-348
Hauptverfasser:	Almasan, Alexandru, Ashkenazi, Avi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apo2L/TRAIL Apoptosis Apoptosis - physiology Apoptosis Regulatory Proteins Carrier Proteins - physiology CASP8 and FADD-Like Apoptosis Regulating Protein Caspases Death receptors Humans Interferons Interferons - physiology Intracellular Signaling Peptides and Proteins Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Mice Models, Biological Neoplasms - immunology Neoplasms - therapy NF-kappa B - physiology Proteins - physiology Proto-Oncogene Proteins c-bcl-2 - physiology Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor - physiology Signal Transduction TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - physiology Virus Diseases - immunology X-Linked Inhibitor of Apoptosis Protein
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