Impact of Olmesartan on Progression of Coronary Atherosclerosis: A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial
The aim of this study was to evaluate the impact of olmesartan on progression of coronary atherosclerosis. Prior intravascular ultrasound (IVUS) trial results suggest slowing of coronary atheroma progression with some medicines but have not shown convincing evidence of regression with angiotension-I...
Gespeichert in:
| Veröffentlicht in: | Journal of the American College of Cardiology 2010-03, Vol.55 (10), p.976-982 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 982 |
|---|---|
| container_issue | 10 |
| container_start_page | 976 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 55 |
| creator | HIROHATA, Atsushi YAMAMOTO, Keizo OHKAWA, Keisuke ISHIZAWA, Makoto YAMAJI, Hirosuke KAWAMURA, Hiroshi KUSACHI, Shozo MURAKAMI, Takashi HINA, Kazuyoshi OHE, Tohru MIYOSHI, Toru HATANAKA, Kunihiko HIROHATA, Satoshi YAMAWAKI, Hitoshi KOMATSUBARA, Issei MURAKAMI, Masaaki HIROSE, Eiki SATO, Shinji |
| description | The aim of this study was to evaluate the impact of olmesartan on progression of coronary atherosclerosis.
Prior intravascular ultrasound (IVUS) trial results suggest slowing of coronary atheroma progression with some medicines but have not shown convincing evidence of regression with angiotension-II receptor blocking agents.
A prospective, randomized, multicenter trial-OLIVUS (Impact of OLmesartan on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound)-was performed in 247 stable angina pectoris patients with native coronary artery disease. When these patients underwent percutaneous coronary intervention for culprit lesions, IVUS was performed in their nonculprit vessels (without angiographically documented coronary stenosis [ |
| doi_str_mv | 10.1016/j.jacc.2009.09.062 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_733706973</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733706973</sourcerecordid><originalsourceid>FETCH-LOGICAL-p268t-978e8614b4a824cf79f7ae8f2309af7d273392aac87481b8700f3f6b2687d1383</originalsourceid><addsrcrecordid>eNpdkU1rGzEQhkVJaRy3f6CHIAgl6WFdSfshqTdjktZgcMGxr8usLDVrtCtX2g34j_ccbezQJkhoJPTOzDMzCH2mZEIJLb7tJjtQasIIkZNhF-wdGtE8F0maS36GRoSneUKJ5OfoIoQdIaQQVH5A54zEldNshP7Omz2oDjuDl7bRAXwHLXYt_uXdb69DqOM9fs6cdy34A552D9q7oOxw1uE7nuKV9jVYvHG2b3Tna4XnbefhEYLqLXi8tvEVXN9u8bQFe4hu-M67BsdQeLmYb9YrfPMfx-LIoZ859q851AsHvOXQj2B76AZddTgSbF4RrAaCr_h-gP2I3huwQX862TFa393ez34mi-WP-Wy6SPasEF0iudCioFmVgWCZMlwaDloYlhIJhm8ZT1PJAJTgmaCV4ISY1BRVdOZbmop0jK6PcWMZf3odurKpg9LWQqtdH8roz0khoxmjqzfKnet9bFcoaZHlcVySZlF1eVL1VaO35d7XTexG-TLQKPhyEsTawRoPrarDPx3LBBcx3ROgJLW9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1645025914</pqid></control><display><type>article</type><title>Impact of Olmesartan on Progression of Coronary Atherosclerosis: A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via ScienceDirect (Elsevier)</source><source>Alma/SFX Local Collection</source><creator>HIROHATA, Atsushi ; YAMAMOTO, Keizo ; OHKAWA, Keisuke ; ISHIZAWA, Makoto ; YAMAJI, Hirosuke ; KAWAMURA, Hiroshi ; KUSACHI, Shozo ; MURAKAMI, Takashi ; HINA, Kazuyoshi ; OHE, Tohru ; MIYOSHI, Toru ; HATANAKA, Kunihiko ; HIROHATA, Satoshi ; YAMAWAKI, Hitoshi ; KOMATSUBARA, Issei ; MURAKAMI, Masaaki ; HIROSE, Eiki ; SATO, Shinji</creator><creatorcontrib>HIROHATA, Atsushi ; YAMAMOTO, Keizo ; OHKAWA, Keisuke ; ISHIZAWA, Makoto ; YAMAJI, Hirosuke ; KAWAMURA, Hiroshi ; KUSACHI, Shozo ; MURAKAMI, Takashi ; HINA, Kazuyoshi ; OHE, Tohru ; MIYOSHI, Toru ; HATANAKA, Kunihiko ; HIROHATA, Satoshi ; YAMAWAKI, Hitoshi ; KOMATSUBARA, Issei ; MURAKAMI, Masaaki ; HIROSE, Eiki ; SATO, Shinji</creatorcontrib><description>The aim of this study was to evaluate the impact of olmesartan on progression of coronary atherosclerosis.
Prior intravascular ultrasound (IVUS) trial results suggest slowing of coronary atheroma progression with some medicines but have not shown convincing evidence of regression with angiotension-II receptor blocking agents.
A prospective, randomized, multicenter trial-OLIVUS (Impact of OLmesartan on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound)-was performed in 247 stable angina pectoris patients with native coronary artery disease. When these patients underwent percutaneous coronary intervention for culprit lesions, IVUS was performed in their nonculprit vessels (without angiographically documented coronary stenosis [<50%]). Patients were randomly assigned to receive 10 to 40 mg of olmesartan or control and treated with a combination of beta-blockers, calcium channel blockers, diuretics, nitrates, glycemic control agents, and/or statins per physician's guidance. Serial IVUS examinations (baseline and 14-month follow-up) were performed to assess coronary atheroma volume. Volumetric IVUS analyses included lumen, plaque, vessel volume, percent atheroma volume (PAV), percent change in total atheroma volume (TAV) and PAV.
Patient characteristics and blood pressure control were identical between the 2 groups. However, follow-up IVUS showed significantly decreased TAV and percent change in PAV in the olmesartan group (5.4% vs. 0.6 % for TAV and 3.1% vs. -0.7% for percent change in PAV, control vs. olmesartan, p < 0.05 for all).
These observations suggest a positive role in a potentially lower rate of coronary atheroma progression through the administration of olmesartan, an angiotension-II receptor blocking agent, for patients with stable angina pectoris.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2009.09.062</identifier><identifier>PMID: 20202514</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Aged ; Angina pectoris ; Angina Pectoris - diagnostic imaging ; Angina Pectoris - drug therapy ; Angina Pectoris - mortality ; Angioplasty, Balloon, Coronary ; Angiotensin II Type 1 Receptor Blockers - adverse effects ; Angiotensin II Type 1 Receptor Blockers - therapeutic use ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Cardiology ; Cardiology. Vascular system ; Coronary Angiography ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - drug therapy ; Coronary heart disease ; Coronary vessels ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - drug effects ; Disease Progression ; Drug therapy ; Female ; Follow-Up Studies ; Heart ; Heart attacks ; Humans ; Image Processing, Computer-Assisted - methods ; Imidazoles - adverse effects ; Imidazoles - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - drug therapy ; Prospective Studies ; Survival Rate ; Tetrazoles - adverse effects ; Tetrazoles - therapeutic use ; Ultrasonography, Interventional - methods ; Veins & arteries</subject><ispartof>Journal of the American College of Cardiology, 2010-03, Vol.55 (10), p.976-982</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 9, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22487873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20202514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIROHATA, Atsushi</creatorcontrib><creatorcontrib>YAMAMOTO, Keizo</creatorcontrib><creatorcontrib>OHKAWA, Keisuke</creatorcontrib><creatorcontrib>ISHIZAWA, Makoto</creatorcontrib><creatorcontrib>YAMAJI, Hirosuke</creatorcontrib><creatorcontrib>KAWAMURA, Hiroshi</creatorcontrib><creatorcontrib>KUSACHI, Shozo</creatorcontrib><creatorcontrib>MURAKAMI, Takashi</creatorcontrib><creatorcontrib>HINA, Kazuyoshi</creatorcontrib><creatorcontrib>OHE, Tohru</creatorcontrib><creatorcontrib>MIYOSHI, Toru</creatorcontrib><creatorcontrib>HATANAKA, Kunihiko</creatorcontrib><creatorcontrib>HIROHATA, Satoshi</creatorcontrib><creatorcontrib>YAMAWAKI, Hitoshi</creatorcontrib><creatorcontrib>KOMATSUBARA, Issei</creatorcontrib><creatorcontrib>MURAKAMI, Masaaki</creatorcontrib><creatorcontrib>HIROSE, Eiki</creatorcontrib><creatorcontrib>SATO, Shinji</creatorcontrib><title>Impact of Olmesartan on Progression of Coronary Atherosclerosis: A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>The aim of this study was to evaluate the impact of olmesartan on progression of coronary atherosclerosis.
Prior intravascular ultrasound (IVUS) trial results suggest slowing of coronary atheroma progression with some medicines but have not shown convincing evidence of regression with angiotension-II receptor blocking agents.
A prospective, randomized, multicenter trial-OLIVUS (Impact of OLmesartan on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound)-was performed in 247 stable angina pectoris patients with native coronary artery disease. When these patients underwent percutaneous coronary intervention for culprit lesions, IVUS was performed in their nonculprit vessels (without angiographically documented coronary stenosis [<50%]). Patients were randomly assigned to receive 10 to 40 mg of olmesartan or control and treated with a combination of beta-blockers, calcium channel blockers, diuretics, nitrates, glycemic control agents, and/or statins per physician's guidance. Serial IVUS examinations (baseline and 14-month follow-up) were performed to assess coronary atheroma volume. Volumetric IVUS analyses included lumen, plaque, vessel volume, percent atheroma volume (PAV), percent change in total atheroma volume (TAV) and PAV.
Patient characteristics and blood pressure control were identical between the 2 groups. However, follow-up IVUS showed significantly decreased TAV and percent change in PAV in the olmesartan group (5.4% vs. 0.6 % for TAV and 3.1% vs. -0.7% for percent change in PAV, control vs. olmesartan, p < 0.05 for all).
These observations suggest a positive role in a potentially lower rate of coronary atheroma progression through the administration of olmesartan, an angiotension-II receptor blocking agent, for patients with stable angina pectoris.</description><subject>Aged</subject><subject>Angina pectoris</subject><subject>Angina Pectoris - diagnostic imaging</subject><subject>Angina Pectoris - drug therapy</subject><subject>Angina Pectoris - mortality</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Angiotensin II Type 1 Receptor Blockers - adverse effects</subject><subject>Angiotensin II Type 1 Receptor Blockers - therapeutic use</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - drug therapy</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - drug effects</subject><subject>Disease Progression</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imidazoles - adverse effects</subject><subject>Imidazoles - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Prospective Studies</subject><subject>Survival Rate</subject><subject>Tetrazoles - adverse effects</subject><subject>Tetrazoles - therapeutic use</subject><subject>Ultrasonography, Interventional - methods</subject><subject>Veins & arteries</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1rGzEQhkVJaRy3f6CHIAgl6WFdSfshqTdjktZgcMGxr8usLDVrtCtX2g34j_ccbezQJkhoJPTOzDMzCH2mZEIJLb7tJjtQasIIkZNhF-wdGtE8F0maS36GRoSneUKJ5OfoIoQdIaQQVH5A54zEldNshP7Omz2oDjuDl7bRAXwHLXYt_uXdb69DqOM9fs6cdy34A552D9q7oOxw1uE7nuKV9jVYvHG2b3Tna4XnbefhEYLqLXi8tvEVXN9u8bQFe4hu-M67BsdQeLmYb9YrfPMfx-LIoZ859q851AsHvOXQj2B76AZddTgSbF4RrAaCr_h-gP2I3huwQX862TFa393ez34mi-WP-Wy6SPasEF0iudCioFmVgWCZMlwaDloYlhIJhm8ZT1PJAJTgmaCV4ISY1BRVdOZbmop0jK6PcWMZf3odurKpg9LWQqtdH8roz0khoxmjqzfKnet9bFcoaZHlcVySZlF1eVL1VaO35d7XTexG-TLQKPhyEsTawRoPrarDPx3LBBcx3ROgJLW9</recordid><startdate>20100309</startdate><enddate>20100309</enddate><creator>HIROHATA, Atsushi</creator><creator>YAMAMOTO, Keizo</creator><creator>OHKAWA, Keisuke</creator><creator>ISHIZAWA, Makoto</creator><creator>YAMAJI, Hirosuke</creator><creator>KAWAMURA, Hiroshi</creator><creator>KUSACHI, Shozo</creator><creator>MURAKAMI, Takashi</creator><creator>HINA, Kazuyoshi</creator><creator>OHE, Tohru</creator><creator>MIYOSHI, Toru</creator><creator>HATANAKA, Kunihiko</creator><creator>HIROHATA, Satoshi</creator><creator>YAMAWAKI, Hitoshi</creator><creator>KOMATSUBARA, Issei</creator><creator>MURAKAMI, Masaaki</creator><creator>HIROSE, Eiki</creator><creator>SATO, Shinji</creator><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20100309</creationdate><title>Impact of Olmesartan on Progression of Coronary Atherosclerosis: A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial</title><author>HIROHATA, Atsushi ; YAMAMOTO, Keizo ; OHKAWA, Keisuke ; ISHIZAWA, Makoto ; YAMAJI, Hirosuke ; KAWAMURA, Hiroshi ; KUSACHI, Shozo ; MURAKAMI, Takashi ; HINA, Kazuyoshi ; OHE, Tohru ; MIYOSHI, Toru ; HATANAKA, Kunihiko ; HIROHATA, Satoshi ; YAMAWAKI, Hitoshi ; KOMATSUBARA, Issei ; MURAKAMI, Masaaki ; HIROSE, Eiki ; SATO, Shinji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p268t-978e8614b4a824cf79f7ae8f2309af7d273392aac87481b8700f3f6b2687d1383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Angina pectoris</topic><topic>Angina Pectoris - diagnostic imaging</topic><topic>Angina Pectoris - drug therapy</topic><topic>Angina Pectoris - mortality</topic><topic>Angioplasty, Balloon, Coronary</topic><topic>Angiotensin II Type 1 Receptor Blockers - adverse effects</topic><topic>Angiotensin II Type 1 Receptor Blockers - therapeutic use</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - drug therapy</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - drug effects</topic><topic>Disease Progression</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Imidazoles - adverse effects</topic><topic>Imidazoles - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Prospective Studies</topic><topic>Survival Rate</topic><topic>Tetrazoles - adverse effects</topic><topic>Tetrazoles - therapeutic use</topic><topic>Ultrasonography, Interventional - methods</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIROHATA, Atsushi</creatorcontrib><creatorcontrib>YAMAMOTO, Keizo</creatorcontrib><creatorcontrib>OHKAWA, Keisuke</creatorcontrib><creatorcontrib>ISHIZAWA, Makoto</creatorcontrib><creatorcontrib>YAMAJI, Hirosuke</creatorcontrib><creatorcontrib>KAWAMURA, Hiroshi</creatorcontrib><creatorcontrib>KUSACHI, Shozo</creatorcontrib><creatorcontrib>MURAKAMI, Takashi</creatorcontrib><creatorcontrib>HINA, Kazuyoshi</creatorcontrib><creatorcontrib>OHE, Tohru</creatorcontrib><creatorcontrib>MIYOSHI, Toru</creatorcontrib><creatorcontrib>HATANAKA, Kunihiko</creatorcontrib><creatorcontrib>HIROHATA, Satoshi</creatorcontrib><creatorcontrib>YAMAWAKI, Hitoshi</creatorcontrib><creatorcontrib>KOMATSUBARA, Issei</creatorcontrib><creatorcontrib>MURAKAMI, Masaaki</creatorcontrib><creatorcontrib>HIROSE, Eiki</creatorcontrib><creatorcontrib>SATO, Shinji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIROHATA, Atsushi</au><au>YAMAMOTO, Keizo</au><au>OHKAWA, Keisuke</au><au>ISHIZAWA, Makoto</au><au>YAMAJI, Hirosuke</au><au>KAWAMURA, Hiroshi</au><au>KUSACHI, Shozo</au><au>MURAKAMI, Takashi</au><au>HINA, Kazuyoshi</au><au>OHE, Tohru</au><au>MIYOSHI, Toru</au><au>HATANAKA, Kunihiko</au><au>HIROHATA, Satoshi</au><au>YAMAWAKI, Hitoshi</au><au>KOMATSUBARA, Issei</au><au>MURAKAMI, Masaaki</au><au>HIROSE, Eiki</au><au>SATO, Shinji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Olmesartan on Progression of Coronary Atherosclerosis: A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2010-03-09</date><risdate>2010</risdate><volume>55</volume><issue>10</issue><spage>976</spage><epage>982</epage><pages>976-982</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>The aim of this study was to evaluate the impact of olmesartan on progression of coronary atherosclerosis.
Prior intravascular ultrasound (IVUS) trial results suggest slowing of coronary atheroma progression with some medicines but have not shown convincing evidence of regression with angiotension-II receptor blocking agents.
A prospective, randomized, multicenter trial-OLIVUS (Impact of OLmesartan on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound)-was performed in 247 stable angina pectoris patients with native coronary artery disease. When these patients underwent percutaneous coronary intervention for culprit lesions, IVUS was performed in their nonculprit vessels (without angiographically documented coronary stenosis [<50%]). Patients were randomly assigned to receive 10 to 40 mg of olmesartan or control and treated with a combination of beta-blockers, calcium channel blockers, diuretics, nitrates, glycemic control agents, and/or statins per physician's guidance. Serial IVUS examinations (baseline and 14-month follow-up) were performed to assess coronary atheroma volume. Volumetric IVUS analyses included lumen, plaque, vessel volume, percent atheroma volume (PAV), percent change in total atheroma volume (TAV) and PAV.
Patient characteristics and blood pressure control were identical between the 2 groups. However, follow-up IVUS showed significantly decreased TAV and percent change in PAV in the olmesartan group (5.4% vs. 0.6 % for TAV and 3.1% vs. -0.7% for percent change in PAV, control vs. olmesartan, p < 0.05 for all).
These observations suggest a positive role in a potentially lower rate of coronary atheroma progression through the administration of olmesartan, an angiotension-II receptor blocking agent, for patients with stable angina pectoris.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>20202514</pmid><doi>10.1016/j.jacc.2009.09.062</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2010-03, Vol.55 (10), p.976-982 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733706973 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier); Alma/SFX Local Collection |
| subjects | Aged Angina pectoris Angina Pectoris - diagnostic imaging Angina Pectoris - drug therapy Angina Pectoris - mortality Angioplasty, Balloon, Coronary Angiotensin II Type 1 Receptor Blockers - adverse effects Angiotensin II Type 1 Receptor Blockers - therapeutic use Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology Cardiology. Vascular system Coronary Angiography Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - drug therapy Coronary heart disease Coronary vessels Coronary Vessels - diagnostic imaging Coronary Vessels - drug effects Disease Progression Drug therapy Female Follow-Up Studies Heart Heart attacks Humans Image Processing, Computer-Assisted - methods Imidazoles - adverse effects Imidazoles - therapeutic use Male Medical sciences Middle Aged Myocardial Infarction - diagnostic imaging Myocardial Infarction - drug therapy Prospective Studies Survival Rate Tetrazoles - adverse effects Tetrazoles - therapeutic use Ultrasonography, Interventional - methods Veins & arteries |
| title | Impact of Olmesartan on Progression of Coronary Atherosclerosis: A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T18%3A20%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Olmesartan%20on%20Progression%20of%20Coronary%20Atherosclerosis:%20A%20Serial%20Volumetric%20Intravascular%20Ultrasound%20Analysis%20From%20the%20OLIVUS%20(Impact%20of%20OLmesarten%20on%20progression%20of%20coronary%20atherosclerosis:%20evaluation%20by%20IntraVascular%20UltraSound)%20Trial&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=HIROHATA,%20Atsushi&rft.date=2010-03-09&rft.volume=55&rft.issue=10&rft.spage=976&rft.epage=982&rft.pages=976-982&rft.issn=0735-1097&rft.eissn=1558-3597&rft.coden=JACCDI&rft_id=info:doi/10.1016/j.jacc.2009.09.062&rft_dat=%3Cproquest_pubme%3E733706973%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1645025914&rft_id=info:pmid/20202514&rfr_iscdi=true |