Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad

The effects of sodium butyrate (SB) and trichostatin A (TSA) on cell proliferation andapoptosis against human glioma T98G, U251MG, and U877MG cells were investigated. Upon exposure to either SB or TSA, cell proliferation was reduced, and apoptosis detected by DNA fragmentation analysis and the cleav...

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Veröffentlicht in:	Brain tumor pathology 2001-09, Vol.18 (2), p.109-114
Hauptverfasser:	Sawa, H, Murakami, H, Ohshima, Y, Sugino, T, Nakajyo, T, Kisanuki, T, Tamura, Y, Satone, A, Ide, W, Hashimoto, I, Kamada, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Brain Neoplasms - pathology Butyrates - pharmacology Cell cycle Cell Division - drug effects Cell growth Cell Line, Tumor - drug effects Cell Line, Tumor - metabolism Enzyme Inhibitors - pharmacology Gene Expression Regulation, Neoplastic - drug effects Glioblastoma - pathology Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Proteins Sodium - pharmacology
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