Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatory cells

Low-dose total body irradiation (LTBI) is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying LTBI remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute nu...

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Veröffentlicht in:	Cellular & molecular immunology 2010-03, Vol.7 (2), p.157-162
Hauptverfasser:	Liu, Rongjun, Xiong, Shudao, Zhang, Lei, Chu, Yiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Vaccines - immunology Cancer Vaccines - therapeutic use Cell Proliferation - radiation effects Cells, Cultured Dendritic Cells - immunology Female Immunologic Memory - radiation effects Interferon-gamma - biosynthesis Interferon-gamma - immunology Mice Mice, Inbred C57BL Neoplasm Transplantation Neoplasms - immunology Neoplasms - pathology T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - radiation effects Whole-Body Irradiation
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