Raising the NKT cell family
Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen–reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated wi...
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| Veröffentlicht in: | Nature immunology 2010-03, Vol.11 (3), p.197-206 |
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| creator | Godfrey, Dale I Stankovic, Sanda Baxter, Alan G |
| description | Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen–reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection. Furthermore, in some diseases, such as atherosclerosis and allergy, NKT cell activity can be deleterious to the host. Although the precise means by which these cells carry out such contrasting functions is unclear, recent studies have highlighted the existence of many functionally distinct NKT cell subsets. Because their frequency and number vary widely between individuals, it is important to understand the mechanisms that regulate the development and maintenance of NKT cells and subsets thereof, which is the subject of this review. |
| doi_str_mv | 10.1038/ni.1841 |
| format | Article |
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Furthermore, in some diseases, such as atherosclerosis and allergy, NKT cell activity can be deleterious to the host. Although the precise means by which these cells carry out such contrasting functions is unclear, recent studies have highlighted the existence of many functionally distinct NKT cell subsets. 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Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godfrey, Dale I</au><au>Stankovic, Sanda</au><au>Baxter, Alan G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Raising the NKT cell family</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>11</volume><issue>3</issue><spage>197</spage><epage>206</epage><pages>197-206</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen–reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection. Furthermore, in some diseases, such as atherosclerosis and allergy, NKT cell activity can be deleterious to the host. Although the precise means by which these cells carry out such contrasting functions is unclear, recent studies have highlighted the existence of many functionally distinct NKT cell subsets. Because their frequency and number vary widely between individuals, it is important to understand the mechanisms that regulate the development and maintenance of NKT cells and subsets thereof, which is the subject of this review.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>20139988</pmid><doi>10.1038/ni.1841</doi><tpages>10</tpages></addata></record> |
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| subjects | 631/250/1619/554/383 Allergies Animals Antigens, CD - immunology Antigens, CD1d - immunology Autoimmune diseases Biomedical and Life Sciences Biomedicine Cell Cycle - immunology Genetic aspects Genetic regulation Health aspects Humans Immune response Immunology Infectious Diseases Interleukins Kruppel-Like Transcription Factors - immunology Lymphocytes Mice Natural Killer T-Cells - immunology Physiological aspects Promyelocytic Leukemia Zinc Finger Protein Receptors, Cell Surface - immunology review-article Signal Transduction Signaling Lymphocytic Activation Molecule Family Member 1 T cells T-Lymphocyte Subsets - immunology |
| title | Raising the NKT cell family |
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