Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice

Lamina-associated polypeptide (LAP)2alpha is a mammalian chromatin-binding protein that interacts with a fraction of A-type lamins in the nuclear interior. Because mutations in lamins and LAP2alpha lead to cardiac disorders in humans, we hypothesized that these factors may play important roles in he...

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Veröffentlicht in:	Circulation research 2010-02, Vol.106 (2), p.346-353
Hauptverfasser:	Gotic, Ivana, Leschnik, Michael, Kolm, Ursula, Markovic, Mato, Haubner, Bernhard J, Biadasiewicz, Katarzyna, Metzler, Bernhard, Stewart, Colin L, Foisner, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Animals Blotting, Western DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Dystrophin - genetics Dystrophin - metabolism Dystrophin - physiology Echocardiography - drug effects Female Fibrosis GATA4 Transcription Factor - genetics GATA4 Transcription Factor - metabolism Gene Expression Regulation, Developmental Heart - embryology Heart - growth & development Heart - physiopathology Isoproterenol - pharmacology Male MEF2 Transcription Factors Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - physiology Mice Mice, Inbred C57BL Mice, Inbred mdx Mice, Knockout Myocardium - metabolism Myocardium - pathology Myogenic Regulatory Factors - genetics Myogenic Regulatory Factors - metabolism Reverse Transcriptase Polymerase Chain Reaction Ventricular Dysfunction, Left - genetics Ventricular Dysfunction, Left - physiopathology
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