Lamotrigine: An Unusual Etiology for Aseptic Meningitis
BACKGROUND:Several drugs have been reported to induce meningitis, most frequent being nonsteroidal anti-inflammatory drugs, antibiotics, intravenous immunoglobulins, and OKT3 antibodies. Although there are rare reports of lamotrigine-associated aseptic meningitis, this is only the second confirmed b...
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| Veröffentlicht in: | The Neurologist (Baltimore, Md.) Md.), 2010-01, Vol.16 (1), p.35-36 |
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| container_title | The Neurologist (Baltimore, Md.) |
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| creator | Lam, Gregory M. Edelson, Dana P. Whelan, Chad T. |
| description | BACKGROUND:Several drugs have been reported to induce meningitis, most frequent being nonsteroidal anti-inflammatory drugs, antibiotics, intravenous immunoglobulins, and OKT3 antibodies. Although there are rare reports of lamotrigine-associated aseptic meningitis, this is only the second confirmed by re-exposure to the medication.
CASE REPORT:We describe a case of lamotrigine-induced aseptic meningitis in a 36-year-old woman with hypothyroidism and bipolar disorder. Symptoms appeared within 2 weeks after starting the medication and resolved over several days after discontinuation. Her complex reappeared one week later within one hour after re-exposure to lamotrigine.
CONCLUSION:Lamotrigine is a rarely reported and possibly underrecognized cause of aseptic meningitis. Physicians should be aware of aseptic meningitis as a potential reaction when prescribing lamotrigine or encountering cases of aseptic meningitis. |
| doi_str_mv | 10.1097/NRL.0b013e31819f9544 |
| format | Article |
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CASE REPORT:We describe a case of lamotrigine-induced aseptic meningitis in a 36-year-old woman with hypothyroidism and bipolar disorder. Symptoms appeared within 2 weeks after starting the medication and resolved over several days after discontinuation. Her complex reappeared one week later within one hour after re-exposure to lamotrigine.
CONCLUSION:Lamotrigine is a rarely reported and possibly underrecognized cause of aseptic meningitis. Physicians should be aware of aseptic meningitis as a potential reaction when prescribing lamotrigine or encountering cases of aseptic meningitis.</description><identifier>ISSN: 1074-7931</identifier><identifier>EISSN: 2331-2637</identifier><identifier>DOI: 10.1097/NRL.0b013e31819f9544</identifier><identifier>PMID: 20065794</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Antimanic Agents - adverse effects ; Antimanic Agents - therapeutic use ; Bipolar Disorder - complications ; Bipolar Disorder - drug therapy ; Female ; Humans ; Hypothyroidism - complications ; Meningitis, Aseptic - chemically induced ; Meningitis, Aseptic - complications ; Time Factors ; Triazines - adverse effects ; Triazines - therapeutic use</subject><ispartof>The Neurologist (Baltimore, Md.), 2010-01, Vol.16 (1), p.35-36</ispartof><rights>2010 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3005-af61bcef7cdc3b3e94c65b0a1403b5a9aabff91d67a734409434aef8560bf4533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20065794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lam, Gregory M.</creatorcontrib><creatorcontrib>Edelson, Dana P.</creatorcontrib><creatorcontrib>Whelan, Chad T.</creatorcontrib><title>Lamotrigine: An Unusual Etiology for Aseptic Meningitis</title><title>The Neurologist (Baltimore, Md.)</title><addtitle>Neurologist</addtitle><description>BACKGROUND:Several drugs have been reported to induce meningitis, most frequent being nonsteroidal anti-inflammatory drugs, antibiotics, intravenous immunoglobulins, and OKT3 antibodies. Although there are rare reports of lamotrigine-associated aseptic meningitis, this is only the second confirmed by re-exposure to the medication.
CASE REPORT:We describe a case of lamotrigine-induced aseptic meningitis in a 36-year-old woman with hypothyroidism and bipolar disorder. Symptoms appeared within 2 weeks after starting the medication and resolved over several days after discontinuation. Her complex reappeared one week later within one hour after re-exposure to lamotrigine.
CONCLUSION:Lamotrigine is a rarely reported and possibly underrecognized cause of aseptic meningitis. Physicians should be aware of aseptic meningitis as a potential reaction when prescribing lamotrigine or encountering cases of aseptic meningitis.</description><subject>Adult</subject><subject>Antimanic Agents - adverse effects</subject><subject>Antimanic Agents - therapeutic use</subject><subject>Bipolar Disorder - complications</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism - complications</subject><subject>Meningitis, Aseptic - chemically induced</subject><subject>Meningitis, Aseptic - complications</subject><subject>Time Factors</subject><subject>Triazines - adverse effects</subject><subject>Triazines - therapeutic use</subject><issn>1074-7931</issn><issn>2331-2637</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLAzEUhYMotlb_gcjsXE29mZtMGnel1AeMCmLXITNN2ug8ajJD6b93Sn2AcC5nc8658BFySWFMQYqb59dsDDlQNEgnVFrJGTsiwwSRxkmK4pgMKQgWC4l0QM5CeAegMk3YKRkkACkXkg2JyHTVtN6tXG1uo2kdLeoudLqM5q1ryma1i2zjo2kwm9YV0ZOpXb1yrQvn5MTqMpiLbx-Rxd38bfYQZy_3j7NpFhcIwGNtU5oXxopiWWCORrIi5TloygBzrqXWubWSLlOhBTIGkiHTxk54CrllHHFErg-7G998dia0qnKhMGWpa9N0QQlEARwE75PskCx8E4I3Vm28q7TfKQpqT0z1xNR_Yn3t6vtBl1dm-Vv6QfS3u23K1vjwUXZb49Xa6LJdq55pIiYS4wQo7AVxf8DxC8TcdrI</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Lam, Gregory M.</creator><creator>Edelson, Dana P.</creator><creator>Whelan, Chad T.</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201001</creationdate><title>Lamotrigine: An Unusual Etiology for Aseptic Meningitis</title><author>Lam, Gregory M. ; Edelson, Dana P. ; Whelan, Chad T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3005-af61bcef7cdc3b3e94c65b0a1403b5a9aabff91d67a734409434aef8560bf4533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Antimanic Agents - adverse effects</topic><topic>Antimanic Agents - therapeutic use</topic><topic>Bipolar Disorder - complications</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothyroidism - complications</topic><topic>Meningitis, Aseptic - chemically induced</topic><topic>Meningitis, Aseptic - complications</topic><topic>Time Factors</topic><topic>Triazines - adverse effects</topic><topic>Triazines - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lam, Gregory M.</creatorcontrib><creatorcontrib>Edelson, Dana P.</creatorcontrib><creatorcontrib>Whelan, Chad T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Neurologist (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lam, Gregory M.</au><au>Edelson, Dana P.</au><au>Whelan, Chad T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lamotrigine: An Unusual Etiology for Aseptic Meningitis</atitle><jtitle>The Neurologist (Baltimore, Md.)</jtitle><addtitle>Neurologist</addtitle><date>2010-01</date><risdate>2010</risdate><volume>16</volume><issue>1</issue><spage>35</spage><epage>36</epage><pages>35-36</pages><issn>1074-7931</issn><eissn>2331-2637</eissn><abstract>BACKGROUND:Several drugs have been reported to induce meningitis, most frequent being nonsteroidal anti-inflammatory drugs, antibiotics, intravenous immunoglobulins, and OKT3 antibodies. Although there are rare reports of lamotrigine-associated aseptic meningitis, this is only the second confirmed by re-exposure to the medication.
CASE REPORT:We describe a case of lamotrigine-induced aseptic meningitis in a 36-year-old woman with hypothyroidism and bipolar disorder. Symptoms appeared within 2 weeks after starting the medication and resolved over several days after discontinuation. Her complex reappeared one week later within one hour after re-exposure to lamotrigine.
CONCLUSION:Lamotrigine is a rarely reported and possibly underrecognized cause of aseptic meningitis. Physicians should be aware of aseptic meningitis as a potential reaction when prescribing lamotrigine or encountering cases of aseptic meningitis.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>20065794</pmid><doi>10.1097/NRL.0b013e31819f9544</doi><tpages>2</tpages></addata></record> |
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| ispartof | The Neurologist (Baltimore, Md.), 2010-01, Vol.16 (1), p.35-36 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Antimanic Agents - adverse effects Antimanic Agents - therapeutic use Bipolar Disorder - complications Bipolar Disorder - drug therapy Female Humans Hypothyroidism - complications Meningitis, Aseptic - chemically induced Meningitis, Aseptic - complications Time Factors Triazines - adverse effects Triazines - therapeutic use |
| title | Lamotrigine: An Unusual Etiology for Aseptic Meningitis |
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