Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Abstract Insulin like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) signalling control vital growth, survival and metabolic functions in the brain. Here we describe specific and significant alterations in IGF-1R, IR, and their key substrate adaptor proteins IRS-1 and IRS-2 in Alzheimer...

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Veröffentlicht in:	Neurobiology of aging 2010-02, Vol.31 (2), p.224-243
Hauptverfasser:	Moloney, Aileen M, Griffin, Rebecca J, Timmons, Suzanne, O’Connor, Rosemary, Ravid, Rivka, O’Neill, Cora
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer's disease Animals Astrocytes - metabolism Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Humans Insulin like growth factor-1 receptor Insulin receptor Insulin receptor substrate proteins Insulin Receptor Substrate Proteins - metabolism Internal Medicine Male Medical sciences Mice Mice, Transgenic Middle Aged Neurofibrillary Tangles - metabolism Neurology Neurons - metabolism Phosphatidylinositol 3-Kinases - metabolism Plaque, Amyloid - metabolism Receptor, IGF Type 1 - metabolism Receptor, Insulin - metabolism Signal Transduction Signalling Temporal Lobe - metabolism Vertebrates: nervous system and sense organs
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