ROLE OF CHRONIC SCHWANN CELL DENERVATION IN POOR FUNCTIONAL RECOVERY AFTER NERVE INJURIES AND EXPERIMENTAL STRATEGIES TO COMBAT IT

To present our data about the role of chronic denervation (CD) of the distal nerve stumps as compared with muscle denervation atrophy and experimental strategies to promote better functional recovery. A rat model of nerve injury and repair was used. The common peroneal branch of the sciatic nerve wa...

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Veröffentlicht in:	Neurosurgery 2009-10, Vol.65 (4), p.A105-A114
Hauptverfasser:	SULAIMAN, Olawale A. R, GORDON, Tessa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Denervation - adverse effects Disease Models, Animal Growth Cones - drug effects Growth Cones - physiology Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Male Medical sciences Nerve Regeneration - drug effects Nerve Regeneration - physiology Nerve Transfer - methods Neurosurgery Rats Recovery of Function - drug effects Recovery of Function - physiology Schwann Cells - cytology Schwann Cells - physiology Sciatic Nerve - physiopathology Sciatic Nerve - surgery Sciatic Neuropathy - physiopathology Sciatic Neuropathy - surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tacrolimus - pharmacology Tacrolimus - therapeutic use Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta - therapeutic use
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