Characterization of quercetin binding site on DNA gyrase

Gyrases are DNA topology modifying enzymes present only in prokaryotes which makes them an attractive target for antibacterial drugs. Quercetin, one of the most abundant natural flavonoids, inhibits supercoiling activity of bacterial gyrase and induces DNA cleavage. It has been generally assumed tha...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-06, Vol.306 (2), p.530-536
Hauptverfasser:	Plaper, Andreja, Golob, Mojca, Hafner, Iva, Oblak, Marko, Šolmajer, Tomaž, Jerala, Roman
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphate - chemistry Adenosine Triphosphate - pharmacology ATP binding site Binding Sites DNA gyrase DNA Gyrase - chemistry Dose-Response Relationship, Drug Escherichia coli - enzymology Flavonoids Flavonoids - chemistry Fluorescence Kinetics Mechanism of DNA gyrase inhibition Models, Molecular Molecular model Novobiocin - pharmacology Protein Binding Protein Structure, Tertiary Protein-Tyrosine Kinases - chemistry Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins c-hck Quercetin - chemistry Spectrometry, Fluorescence Time Factors
Online-Zugang:	Volltext
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