Adenosine Stress Magnetic Resonance Imaging in Women With Low Risk Chest Pain: The Emory University Experience
The purpose of this study was to evaluate the accuracy of adenosine stress magnetic resonance imaging (ASMRI) for the evaluation of women with low-risk chest pain (CP). Coronary artery disease (CAD) can present differently among women than among men. There is increased interest in the use of ASMRI f...
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| Veröffentlicht in: | The American journal of the medical sciences 2010-03, Vol.339 (3), p.216-220 |
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| container_title | The American journal of the medical sciences |
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| creator | Lerakis, Stamatios Janik, Matthew McLean, Dalton S. Anadiotis, Athanasios V. Zaragoza-Macias, Elisa Veledar, Emir Oshinski, John Stillman, Arthur E. |
| description | The purpose of this study was to evaluate the accuracy of adenosine stress magnetic resonance imaging (ASMRI) for the evaluation of women with low-risk chest pain (CP).
Coronary artery disease (CAD) can present differently among women than among men. There is increased interest in the use of ASMRI for lower risk patients in the emergency department to rule out CAD, and it would be valuable to assess its performance specifically in women.
This study included 82 women with low-risk CP who presented to the emergency department during a 2-year period at our institution and were evaluated by ASMRI. Clinical events were followed by review of medical records.
The specificity of ASMRI for ischemia detection in this small cohort of patients was 100%. Sensitivity was 94.9%, negative predictive value 100%, and positive predictive value 42.9%.
ASMRI may be used as the initial imaging modality for ruling out CAD in women with low-risk CP because of its very high sensitivity, specificity, and negative predictive value for the detection of ischemia. Further randomized controlled trials comparing ASMRI with established noninvasive nuclear and echocardiographic stress modalities are needed. |
| doi_str_mv | 10.1097/MAJ.0b013e3181c6bfcc |
| format | Article |
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Coronary artery disease (CAD) can present differently among women than among men. There is increased interest in the use of ASMRI for lower risk patients in the emergency department to rule out CAD, and it would be valuable to assess its performance specifically in women.
This study included 82 women with low-risk CP who presented to the emergency department during a 2-year period at our institution and were evaluated by ASMRI. Clinical events were followed by review of medical records.
The specificity of ASMRI for ischemia detection in this small cohort of patients was 100%. Sensitivity was 94.9%, negative predictive value 100%, and positive predictive value 42.9%.
ASMRI may be used as the initial imaging modality for ruling out CAD in women with low-risk CP because of its very high sensitivity, specificity, and negative predictive value for the detection of ischemia. Further randomized controlled trials comparing ASMRI with established noninvasive nuclear and echocardiographic stress modalities are needed.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/MAJ.0b013e3181c6bfcc</identifier><identifier>PMID: 20051822</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Academic Medical Centers - methods ; Adenosine ; Adenosine stress ; Adult ; Aged ; Biological and medical sciences ; Cardiac magnetic resonance ; Chest Pain - diagnosis ; Chest Pain - physiopathology ; Cohort Studies ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - physiopathology ; Exercise Test - methods ; Female ; Follow-Up Studies ; General aspects ; Georgia ; Humans ; Low-risk chest pain ; Magnetic Resonance Imaging - methods ; Medical sciences ; Middle Aged ; Risk Factors ; Women</subject><ispartof>The American journal of the medical sciences, 2010-03, Vol.339 (3), p.216-220</ispartof><rights>2010 Southern Society for Clinical Investigation</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-322feafe6faf2ab9ffe40de92966222878d20d7496a673213122877f2861a4f23</citedby><cites>FETCH-LOGICAL-c391t-322feafe6faf2ab9ffe40de92966222878d20d7496a673213122877f2861a4f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22554921$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20051822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lerakis, Stamatios</creatorcontrib><creatorcontrib>Janik, Matthew</creatorcontrib><creatorcontrib>McLean, Dalton S.</creatorcontrib><creatorcontrib>Anadiotis, Athanasios V.</creatorcontrib><creatorcontrib>Zaragoza-Macias, Elisa</creatorcontrib><creatorcontrib>Veledar, Emir</creatorcontrib><creatorcontrib>Oshinski, John</creatorcontrib><creatorcontrib>Stillman, Arthur E.</creatorcontrib><title>Adenosine Stress Magnetic Resonance Imaging in Women With Low Risk Chest Pain: The Emory University Experience</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>The purpose of this study was to evaluate the accuracy of adenosine stress magnetic resonance imaging (ASMRI) for the evaluation of women with low-risk chest pain (CP).
Coronary artery disease (CAD) can present differently among women than among men. There is increased interest in the use of ASMRI for lower risk patients in the emergency department to rule out CAD, and it would be valuable to assess its performance specifically in women.
This study included 82 women with low-risk CP who presented to the emergency department during a 2-year period at our institution and were evaluated by ASMRI. Clinical events were followed by review of medical records.
The specificity of ASMRI for ischemia detection in this small cohort of patients was 100%. Sensitivity was 94.9%, negative predictive value 100%, and positive predictive value 42.9%.
ASMRI may be used as the initial imaging modality for ruling out CAD in women with low-risk CP because of its very high sensitivity, specificity, and negative predictive value for the detection of ischemia. Further randomized controlled trials comparing ASMRI with established noninvasive nuclear and echocardiographic stress modalities are needed.</description><subject>Academic Medical Centers - methods</subject><subject>Adenosine</subject><subject>Adenosine stress</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiac magnetic resonance</subject><subject>Chest Pain - diagnosis</subject><subject>Chest Pain - physiopathology</subject><subject>Cohort Studies</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Exercise Test - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Georgia</subject><subject>Humans</subject><subject>Low-risk chest pain</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Women</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFuEzEQhi1ERUPgDarKF8RpW3u82V1zQIqiQFulApVWHC3HO04MWTvYm0DeHrdJW4kDl7E0-v7xr4-QE87OOJP1-fX46ozNGRcoeMNNNbfGvCADPhJNAVKyl2TAGINCViCPyeuUfjDGoeHiFTkGxka8ARgQP27Rh-Q80m99xJTotV547J2hN5iC194gvez0wvkFdZ5-Dx3m6folnYXf9Maln3SyxNTTr9r5D_R2iXTahbijd95tMSbX7-j0zxqjw3zqDTmyepXw7eEdkrtP09vJRTH78vlyMp4VRkjeFwLAorZYWW1Bz6W1WLIWJciqAoCmblpgbV3KSle1AC74_bK20FRclxbEkLzf313H8GuT66nOJYOrlfYYNknVQtQsZ8pMlnvSxJBSRKvW0XU67hRn6l60yqLVv6Jz7PTwwWbeYfsUejSbgXcHQCejVzZmky49czAalTI3H5KPew6zjq3DqJJ5UNW6iKZXbXD_b_IXT_qcfA</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Lerakis, Stamatios</creator><creator>Janik, Matthew</creator><creator>McLean, Dalton S.</creator><creator>Anadiotis, Athanasios V.</creator><creator>Zaragoza-Macias, Elisa</creator><creator>Veledar, Emir</creator><creator>Oshinski, John</creator><creator>Stillman, Arthur E.</creator><general>Elsevier Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Adenosine Stress Magnetic Resonance Imaging in Women With Low Risk Chest Pain: The Emory University Experience</title><author>Lerakis, Stamatios ; Janik, Matthew ; McLean, Dalton S. ; Anadiotis, Athanasios V. ; Zaragoza-Macias, Elisa ; Veledar, Emir ; Oshinski, John ; Stillman, Arthur E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-322feafe6faf2ab9ffe40de92966222878d20d7496a673213122877f2861a4f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Academic Medical Centers - methods</topic><topic>Adenosine</topic><topic>Adenosine stress</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiac magnetic resonance</topic><topic>Chest Pain - diagnosis</topic><topic>Chest Pain - physiopathology</topic><topic>Cohort Studies</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Exercise Test - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Georgia</topic><topic>Humans</topic><topic>Low-risk chest pain</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lerakis, Stamatios</creatorcontrib><creatorcontrib>Janik, Matthew</creatorcontrib><creatorcontrib>McLean, Dalton S.</creatorcontrib><creatorcontrib>Anadiotis, Athanasios V.</creatorcontrib><creatorcontrib>Zaragoza-Macias, Elisa</creatorcontrib><creatorcontrib>Veledar, Emir</creatorcontrib><creatorcontrib>Oshinski, John</creatorcontrib><creatorcontrib>Stillman, Arthur E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lerakis, Stamatios</au><au>Janik, Matthew</au><au>McLean, Dalton S.</au><au>Anadiotis, Athanasios V.</au><au>Zaragoza-Macias, Elisa</au><au>Veledar, Emir</au><au>Oshinski, John</au><au>Stillman, Arthur E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenosine Stress Magnetic Resonance Imaging in Women With Low Risk Chest Pain: The Emory University Experience</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>339</volume><issue>3</issue><spage>216</spage><epage>220</epage><pages>216-220</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>The purpose of this study was to evaluate the accuracy of adenosine stress magnetic resonance imaging (ASMRI) for the evaluation of women with low-risk chest pain (CP).
Coronary artery disease (CAD) can present differently among women than among men. There is increased interest in the use of ASMRI for lower risk patients in the emergency department to rule out CAD, and it would be valuable to assess its performance specifically in women.
This study included 82 women with low-risk CP who presented to the emergency department during a 2-year period at our institution and were evaluated by ASMRI. Clinical events were followed by review of medical records.
The specificity of ASMRI for ischemia detection in this small cohort of patients was 100%. Sensitivity was 94.9%, negative predictive value 100%, and positive predictive value 42.9%.
ASMRI may be used as the initial imaging modality for ruling out CAD in women with low-risk CP because of its very high sensitivity, specificity, and negative predictive value for the detection of ischemia. Further randomized controlled trials comparing ASMRI with established noninvasive nuclear and echocardiographic stress modalities are needed.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>20051822</pmid><doi>10.1097/MAJ.0b013e3181c6bfcc</doi><tpages>5</tpages></addata></record> |
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| subjects | Academic Medical Centers - methods Adenosine Adenosine stress Adult Aged Biological and medical sciences Cardiac magnetic resonance Chest Pain - diagnosis Chest Pain - physiopathology Cohort Studies Coronary Artery Disease - diagnosis Coronary Artery Disease - physiopathology Exercise Test - methods Female Follow-Up Studies General aspects Georgia Humans Low-risk chest pain Magnetic Resonance Imaging - methods Medical sciences Middle Aged Risk Factors Women |
| title | Adenosine Stress Magnetic Resonance Imaging in Women With Low Risk Chest Pain: The Emory University Experience |
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