Crystal Structure Analysis of Free and Substrate-Bound 6-Hydroxy-l-Nicotine Oxidase from Arthrobacter nicotinovorans

The pathway for oxidative degradation of nicotine in Arthrobacter nicotinovorans includes two genetically and structurally unrelated flavoenzymes, 6-hydroxy-l-nicotine oxidase (6HLNO) and 6-hydroxy-d-nicotine oxidase, which act with absolute stereospecificity on the l- and d-forms, respectively, of...

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Veröffentlicht in:	Journal of molecular biology 2010-02, Vol.396 (3), p.785-799
Hauptverfasser:	Kachalova, Galina S., Bourenkov, Gleb P., Mengesdorf, Thorsten, Schenk, Susann, Maun, Henry R., Burghammer, Manfred, Riekel, Christian, Decker, Karl, Bartunik, Hans D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthrobacter - enzymology combined isomorphous and MAD phasing Crystallography, X-Ray FAD-linked oxidase Models, Molecular Nicotine - analogs & derivatives Nicotine - metabolism nicotine catabolism Oxidoreductases Acting on CH-NH Group Donors - chemistry Phosphatidic Acids - metabolism phospholipid binding Protein Binding Protein Structure, Quaternary Protein Subunits - chemistry stereospecificity
Online-Zugang:	Volltext
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