Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantation

Rebuilding brain structure and neural circuitries by transplantation of fetal tissue is a strategy to repair the damaged nervous system and is currently being investigated using striatal primordium in Huntington's disease (HD) patients. Four HD patients underwent bilateral transplantation with...

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Veröffentlicht in:	Experimental neurology 2010-03, Vol.222 (1), p.30-41
Hauptverfasser:	Gallina, Pasquale, Paganini, Marco, Lombardini, Letizia, Mascalchi, Mario, Porfirio, Berardino, Gadda, Davide, Marini, Mirca, Pinzani, Pamela, Salvianti, Francesca, Crescioli, Clara, Bucciantini, Sandra, Mechi, Claudia, Sarchielli, Erica, Romoli, Anna Maria, Bertini, Elisabetta, Urbani, Serena, Bartolozzi, Benedetta, De Cristofaro, Maria Teresa, Piacentini, Silvia, Saccardi, Riccardo, Pupi, Alberto, Vannelli, Gabriella Barbara, Di Lorenzo, Nicola
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Brain repair Brain Tissue Transplantation - methods Cell migration Cell Movement - physiology Corpus Striatum - cytology Corpus Striatum - diagnostic imaging Corpus Striatum - transplantation Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enzyme-Linked Immunosorbent Assay - methods Female Fetal neural transplant Fetus Fluorodeoxyglucose F18 Follow-Up Studies Gene Expression Regulation - physiology HLA Antigens - metabolism Humans Huntington Disease - diagnostic imaging Huntington Disease - physiopathology Huntington Disease - surgery Huntington's disease Imaging, Three-Dimensional - methods Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurologic Examination - methods Neurology Neurotransplantation Protein Binding - physiology Receptors, Dopamine D2 - metabolism RNA, Messenger - metabolism Severity of Illness Index Striatum Tomography, Emission-Computed, Single-Photon - methods
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