Homocysteine and cerebral infarction in Finnish male smokers
Homocysteine is associated with stroke, but it is not clear whether this relationship is causal. We examined the association between total serum homocysteine concentration (tHcy) and cerebral infarction in a cohort of Finnish male smokers. This is a matched case-control study of 201 cases of cerebra...
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| Veröffentlicht in: | Stroke (1970) 2003-06, Vol.34 (6), p.1359-1363 |
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| container_title | Stroke (1970) |
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| creator | FALLON, Una B VIRTAMO, Jarmo YOUNG, Ian MCMASTER, Dorothy BEN-SHLOMO, Yoav WOOD, Nigel WHITEHEAD, Alexander S SMITH, George Davey |
| description | Homocysteine is associated with stroke, but it is not clear whether this relationship is causal. We examined the association between total serum homocysteine concentration (tHcy) and cerebral infarction in a cohort of Finnish male smokers.
This is a matched case-control study of 201 cases of cerebral infarction and 201 concurrently sampled age-matched controls nested in a cohort of 13 840 male smokers free of cardiovascular disease at the completion of the Alpha-Tocopherol and Beta-Carotene (ATBC) Cancer Prevention study. Conditional logistic regression was used to calculate odds ratios (ORs) and to adjust for confounding variables. An unmatched analysis was also performed.
The geometric mean tHcy was 13.3 micromol/L (95% CI, 12.6 to 13.9) in cases and 12.6 micromol/L (95% CI, 12.0 to 13.2) in controls (P=0.09). There was a graded increase in the OR of cerebral infarction per quartile increase in tHcy (OR, 1.0, 1.7, 1.9, 2.1; trend P=0.02; 201 case-control pairs) when adjusted for traditional risk factors. There was a similar trend in a subgroup of 120 case-control pairs for which further adjustment for lifestyle factors was possible (OR, 1.0, 1.9, 2.5, 2.2; trend P=0.07 in the matched analyses; OR, 1.0, 1.2, 1.9, 2.0; trend P=0.02 in the unmatched analyses). The adjusted OR per 1-SD increase in log-transformed tHcy (equivalent to 4.7 micromol) was 1.4 (95% CI, 1.1 to 1.7; P=0.01).
tHcy appears to predict cerebral infarction in Finnish male smokers. |
| doi_str_mv | 10.1161/01.STR.0000074035.64365.2D |
| format | Article |
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This is a matched case-control study of 201 cases of cerebral infarction and 201 concurrently sampled age-matched controls nested in a cohort of 13 840 male smokers free of cardiovascular disease at the completion of the Alpha-Tocopherol and Beta-Carotene (ATBC) Cancer Prevention study. Conditional logistic regression was used to calculate odds ratios (ORs) and to adjust for confounding variables. An unmatched analysis was also performed.
The geometric mean tHcy was 13.3 micromol/L (95% CI, 12.6 to 13.9) in cases and 12.6 micromol/L (95% CI, 12.0 to 13.2) in controls (P=0.09). There was a graded increase in the OR of cerebral infarction per quartile increase in tHcy (OR, 1.0, 1.7, 1.9, 2.1; trend P=0.02; 201 case-control pairs) when adjusted for traditional risk factors. There was a similar trend in a subgroup of 120 case-control pairs for which further adjustment for lifestyle factors was possible (OR, 1.0, 1.9, 2.5, 2.2; trend P=0.07 in the matched analyses; OR, 1.0, 1.2, 1.9, 2.0; trend P=0.02 in the unmatched analyses). The adjusted OR per 1-SD increase in log-transformed tHcy (equivalent to 4.7 micromol) was 1.4 (95% CI, 1.1 to 1.7; P=0.01).
tHcy appears to predict cerebral infarction in Finnish male smokers.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000074035.64365.2D</identifier><identifier>PMID: 12750538</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Blood Pressure ; Case-Control Studies ; Cerebral Infarction - blood ; Cerebral Infarction - epidemiology ; Cohort Studies ; Confounding Factors (Epidemiology) ; Finland - epidemiology ; Folic Acid - blood ; Homocysteine - blood ; Humans ; Life Style ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Neurology ; Odds Ratio ; Predictive Value of Tests ; Randomized Controlled Trials as Topic - statistics & numerical data ; Risk Assessment ; Risk Factors ; Smoking - blood ; Smoking - epidemiology ; Vascular diseases and vascular malformations of the nervous system ; Vitamin B 6 - blood</subject><ispartof>Stroke (1970), 2003-06, Vol.34 (6), p.1359-1363</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-b785460f5776fc2ea6bea65961f84f4661e69d191a1b5e088daf1108b1a668d13</citedby><cites>FETCH-LOGICAL-c499t-b785460f5776fc2ea6bea65961f84f4661e69d191a1b5e088daf1108b1a668d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14881734$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12750538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FALLON, Una B</creatorcontrib><creatorcontrib>VIRTAMO, Jarmo</creatorcontrib><creatorcontrib>YOUNG, Ian</creatorcontrib><creatorcontrib>MCMASTER, Dorothy</creatorcontrib><creatorcontrib>BEN-SHLOMO, Yoav</creatorcontrib><creatorcontrib>WOOD, Nigel</creatorcontrib><creatorcontrib>WHITEHEAD, Alexander S</creatorcontrib><creatorcontrib>SMITH, George Davey</creatorcontrib><title>Homocysteine and cerebral infarction in Finnish male smokers</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Homocysteine is associated with stroke, but it is not clear whether this relationship is causal. We examined the association between total serum homocysteine concentration (tHcy) and cerebral infarction in a cohort of Finnish male smokers.
This is a matched case-control study of 201 cases of cerebral infarction and 201 concurrently sampled age-matched controls nested in a cohort of 13 840 male smokers free of cardiovascular disease at the completion of the Alpha-Tocopherol and Beta-Carotene (ATBC) Cancer Prevention study. Conditional logistic regression was used to calculate odds ratios (ORs) and to adjust for confounding variables. An unmatched analysis was also performed.
The geometric mean tHcy was 13.3 micromol/L (95% CI, 12.6 to 13.9) in cases and 12.6 micromol/L (95% CI, 12.0 to 13.2) in controls (P=0.09). There was a graded increase in the OR of cerebral infarction per quartile increase in tHcy (OR, 1.0, 1.7, 1.9, 2.1; trend P=0.02; 201 case-control pairs) when adjusted for traditional risk factors. There was a similar trend in a subgroup of 120 case-control pairs for which further adjustment for lifestyle factors was possible (OR, 1.0, 1.9, 2.5, 2.2; trend P=0.07 in the matched analyses; OR, 1.0, 1.2, 1.9, 2.0; trend P=0.02 in the unmatched analyses). The adjusted OR per 1-SD increase in log-transformed tHcy (equivalent to 4.7 micromol) was 1.4 (95% CI, 1.1 to 1.7; P=0.01).
tHcy appears to predict cerebral infarction in Finnish male smokers.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Case-Control Studies</subject><subject>Cerebral Infarction - blood</subject><subject>Cerebral Infarction - epidemiology</subject><subject>Cohort Studies</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Finland - epidemiology</subject><subject>Folic Acid - blood</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Life Style</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Randomized Controlled Trials as Topic - statistics & numerical data</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Smoking - blood</subject><subject>Smoking - epidemiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vitamin B 6 - blood</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotlb_giyC3nbN5Guz4kVaa4WCoPUcstkEV_ejJttD_72pLXRgmDk8My88CN0AzgAE3GPIPlbvGd5VzjDlmWBU8IzMTtAYOGEpE0SeojHGtEgJK4oRugjhO-KESn6ORkByjjmVY_S46NvebMNg684muqsSY70tvW6SunPam6Huu7gm87rr6vCVtLqxSWj7H-vDJTpzugn26jAn6HP-vJou0uXby-v0aZmamD2kZS45E9jxPBfOEKtFGZsXApxkjgkBVhQVFKCh5BZLWWkHgGUJWghZAZ2gu_3fte9_NzYMqq2DsU2jO9tvgsopzTFQGsGHPWh8H4K3Tq193Wq_VYDVzp3CoKI7dXSn_t0pMovH14eUTdna6nh6kBWB2wOgg9GN87ozdThyTErIKaN_qQF3AQ</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>FALLON, Una B</creator><creator>VIRTAMO, Jarmo</creator><creator>YOUNG, Ian</creator><creator>MCMASTER, Dorothy</creator><creator>BEN-SHLOMO, Yoav</creator><creator>WOOD, Nigel</creator><creator>WHITEHEAD, Alexander S</creator><creator>SMITH, George Davey</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Homocysteine and cerebral infarction in Finnish male smokers</title><author>FALLON, Una B ; VIRTAMO, Jarmo ; YOUNG, Ian ; MCMASTER, Dorothy ; BEN-SHLOMO, Yoav ; WOOD, Nigel ; WHITEHEAD, Alexander S ; SMITH, George Davey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-b785460f5776fc2ea6bea65961f84f4661e69d191a1b5e088daf1108b1a668d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Case-Control Studies</topic><topic>Cerebral Infarction - blood</topic><topic>Cerebral Infarction - epidemiology</topic><topic>Cohort Studies</topic><topic>Confounding Factors (Epidemiology)</topic><topic>Finland - epidemiology</topic><topic>Folic Acid - blood</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Life Style</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Randomized Controlled Trials as Topic - statistics & numerical data</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Smoking - blood</topic><topic>Smoking - epidemiology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vitamin B 6 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FALLON, Una B</creatorcontrib><creatorcontrib>VIRTAMO, Jarmo</creatorcontrib><creatorcontrib>YOUNG, Ian</creatorcontrib><creatorcontrib>MCMASTER, Dorothy</creatorcontrib><creatorcontrib>BEN-SHLOMO, Yoav</creatorcontrib><creatorcontrib>WOOD, Nigel</creatorcontrib><creatorcontrib>WHITEHEAD, Alexander S</creatorcontrib><creatorcontrib>SMITH, George Davey</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FALLON, Una B</au><au>VIRTAMO, Jarmo</au><au>YOUNG, Ian</au><au>MCMASTER, Dorothy</au><au>BEN-SHLOMO, Yoav</au><au>WOOD, Nigel</au><au>WHITEHEAD, Alexander S</au><au>SMITH, George Davey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocysteine and cerebral infarction in Finnish male smokers</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>34</volume><issue>6</issue><spage>1359</spage><epage>1363</epage><pages>1359-1363</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Homocysteine is associated with stroke, but it is not clear whether this relationship is causal. We examined the association between total serum homocysteine concentration (tHcy) and cerebral infarction in a cohort of Finnish male smokers.
This is a matched case-control study of 201 cases of cerebral infarction and 201 concurrently sampled age-matched controls nested in a cohort of 13 840 male smokers free of cardiovascular disease at the completion of the Alpha-Tocopherol and Beta-Carotene (ATBC) Cancer Prevention study. Conditional logistic regression was used to calculate odds ratios (ORs) and to adjust for confounding variables. An unmatched analysis was also performed.
The geometric mean tHcy was 13.3 micromol/L (95% CI, 12.6 to 13.9) in cases and 12.6 micromol/L (95% CI, 12.0 to 13.2) in controls (P=0.09). There was a graded increase in the OR of cerebral infarction per quartile increase in tHcy (OR, 1.0, 1.7, 1.9, 2.1; trend P=0.02; 201 case-control pairs) when adjusted for traditional risk factors. There was a similar trend in a subgroup of 120 case-control pairs for which further adjustment for lifestyle factors was possible (OR, 1.0, 1.9, 2.5, 2.2; trend P=0.07 in the matched analyses; OR, 1.0, 1.2, 1.9, 2.0; trend P=0.02 in the unmatched analyses). The adjusted OR per 1-SD increase in log-transformed tHcy (equivalent to 4.7 micromol) was 1.4 (95% CI, 1.1 to 1.7; P=0.01).
tHcy appears to predict cerebral infarction in Finnish male smokers.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12750538</pmid><doi>10.1161/01.STR.0000074035.64365.2D</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association; Journals@Ovid Ovid Autoload; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Aged Biological and medical sciences Blood Pressure Case-Control Studies Cerebral Infarction - blood Cerebral Infarction - epidemiology Cohort Studies Confounding Factors (Epidemiology) Finland - epidemiology Folic Acid - blood Homocysteine - blood Humans Life Style Logistic Models Male Medical sciences Middle Aged Neurology Odds Ratio Predictive Value of Tests Randomized Controlled Trials as Topic - statistics & numerical data Risk Assessment Risk Factors Smoking - blood Smoking - epidemiology Vascular diseases and vascular malformations of the nervous system Vitamin B 6 - blood |
| title | Homocysteine and cerebral infarction in Finnish male smokers |
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