NMR Spectroscopy Reveals that RNase A is Chiefly Denatured in 40% Acetic Acid: Implications for Oligomer Formation by 3D Domain Swapping

Protein self-recognition is essential in many biochemical processes and its study is of fundamental interest to understand the molecular mechanism of amyloid formation. Ribonuclease A (RNase A) is a monomeric protein that may form several oligomers by 3D domain swapping of its N-terminal α-helix, C-...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-02, Vol.132 (5), p.1621-1630
Hauptverfasser:	López-Alonso, Jorge Pedro, Bruix, Marta, Font, Josep, Ribó, Marc, Vilanova, Maria, Jiménez, María Angeles, Santoro, Jorge, González, Carlos, Laurents, Douglas V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid - chemistry Animals Cattle Models, Molecular Nuclear Magnetic Resonance, Biomolecular Protein Denaturation Protein Multimerization Protein Structure, Tertiary Ribonuclease, Pancreatic - chemistry
Online-Zugang:	Volltext
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