Enzyme engineering for enantioselectivity: from trial-and-error to rational design?

The availability of tailored enzymes is crucial for the implementation of biocatalysis in organic chemistry. Enantioselectivity is one key parameter defining the usefulness of an enzyme and, therefore, the competitiveness of the corresponding industrial process. Hence, identification of enzymes with...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2010-01, Vol.28 (1), p.46-54
Hauptverfasser:	Otten, Linda G, Hollmann, Frank, Arends, Isabel W.C.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amino Acid Sequence Amino acids Biocatalysis Biocatalysts Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Cell growth Design Directed Molecular Evolution - methods Enzymes Enzymes - biosynthesis Enzymes - genetics Fundamental and applied biological sciences. Psychology Gene Library Internal Medicine Libraries Methods Methods. Procedures. Technologies Multiculturalism & pluralism Mutagenesis Mutation Peptide Library Protein Engineering - methods Proteins Spectrum analysis Stereoisomerism
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