A novel herpesvirus in the sanctuary chimpanzees on Ngamba Island in Uganda
Background Recent studies in non‐human primates have led to the discovery of novel primate herpesviruses. In order to get more information on herpesvirus infections in apes, we studied wild born captive chimpanzees. Methods Chimpanzees of the Ngamba island sanctuary, Uganda, were analyzed with pan...
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| Veröffentlicht in: | Journal of medical primatology 2010-02, Vol.39 (1), p.71-76 |
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| creator | Mugisha, L. Leendertz, F.H. Opuda-Asibo, J. Olobo, J.O. Ehlers, B. |
| description | Background Recent studies in non‐human primates have led to the discovery of novel primate herpesviruses. In order to get more information on herpesvirus infections in apes, we studied wild born captive chimpanzees.
Methods Chimpanzees of the Ngamba island sanctuary, Uganda, were analyzed with pan‐herpes polymerase chain reaction (PCR) targeting the herpesvirus DNA polymerase gene and the glycoprotein B gene. The obtained sequences were connected by long‐distance PCR, and analyzed phylogenetically.
Results Twenty‐one of 40 individuals were infected with members of the Gammaherpesvirinae, two of them with a novel member of this subfamily. Phylogenetically, the novel virus fell into a clade of primate rhadinoviruses and the Kaposi sarcoma herpesvirus (human herpesvirus 8), representing a third distinct rhadinovirus in chimpanzees.
Conclusion Non‐human primates harbor several herpesviruses many of which are still unknown. This has implications to management of primates in sanctuaries requiring continuous updates on the management protocols to deal with potential occupational pathogens. |
| doi_str_mv | 10.1111/j.1600-0684.2009.00396.x |
| format | Article |
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Methods Chimpanzees of the Ngamba island sanctuary, Uganda, were analyzed with pan‐herpes polymerase chain reaction (PCR) targeting the herpesvirus DNA polymerase gene and the glycoprotein B gene. The obtained sequences were connected by long‐distance PCR, and analyzed phylogenetically.
Results Twenty‐one of 40 individuals were infected with members of the Gammaherpesvirinae, two of them with a novel member of this subfamily. Phylogenetically, the novel virus fell into a clade of primate rhadinoviruses and the Kaposi sarcoma herpesvirus (human herpesvirus 8), representing a third distinct rhadinovirus in chimpanzees.
Conclusion Non‐human primates harbor several herpesviruses many of which are still unknown. This has implications to management of primates in sanctuaries requiring continuous updates on the management protocols to deal with potential occupational pathogens.</description><identifier>ISSN: 0047-2565</identifier><identifier>EISSN: 1600-0684</identifier><identifier>DOI: 10.1111/j.1600-0684.2009.00396.x</identifier><identifier>PMID: 19900168</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Animals, Zoo ; Ape Diseases - virology ; Base Sequence ; chimpanzee ; DNA polymerase ; DNA, Viral - chemistry ; DNA, Viral - genetics ; Female ; glycoprotein B ; Herpesviridae - genetics ; Herpesviridae - isolation & purification ; Herpesviridae Infections - veterinary ; Herpesviridae Infections - virology ; herpesvirus ; Male ; Molecular Sequence Data ; Pan troglodytes ; Phylogeny ; polymerase chain reaction ; Polymerase Chain Reaction - veterinary ; sanctuary ; Sequence Alignment ; Uganda ; Viral Envelope Proteins - chemistry ; Viral Envelope Proteins - genetics</subject><ispartof>Journal of medical primatology, 2010-02, Vol.39 (1), p.71-76</ispartof><rights>2009 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4556-3614459821389bd442d506a9cd775c3bb7f05dc5f720fdce1a32b70dba588cfc3</citedby><cites>FETCH-LOGICAL-c4556-3614459821389bd442d506a9cd775c3bb7f05dc5f720fdce1a32b70dba588cfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0684.2009.00396.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0684.2009.00396.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19900168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mugisha, L.</creatorcontrib><creatorcontrib>Leendertz, F.H.</creatorcontrib><creatorcontrib>Opuda-Asibo, J.</creatorcontrib><creatorcontrib>Olobo, J.O.</creatorcontrib><creatorcontrib>Ehlers, B.</creatorcontrib><title>A novel herpesvirus in the sanctuary chimpanzees on Ngamba Island in Uganda</title><title>Journal of medical primatology</title><addtitle>J Med Primatol</addtitle><description>Background Recent studies in non‐human primates have led to the discovery of novel primate herpesviruses. In order to get more information on herpesvirus infections in apes, we studied wild born captive chimpanzees.
Methods Chimpanzees of the Ngamba island sanctuary, Uganda, were analyzed with pan‐herpes polymerase chain reaction (PCR) targeting the herpesvirus DNA polymerase gene and the glycoprotein B gene. The obtained sequences were connected by long‐distance PCR, and analyzed phylogenetically.
Results Twenty‐one of 40 individuals were infected with members of the Gammaherpesvirinae, two of them with a novel member of this subfamily. Phylogenetically, the novel virus fell into a clade of primate rhadinoviruses and the Kaposi sarcoma herpesvirus (human herpesvirus 8), representing a third distinct rhadinovirus in chimpanzees.
Conclusion Non‐human primates harbor several herpesviruses many of which are still unknown. This has implications to management of primates in sanctuaries requiring continuous updates on the management protocols to deal with potential occupational pathogens.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Animals, Zoo</subject><subject>Ape Diseases - virology</subject><subject>Base Sequence</subject><subject>chimpanzee</subject><subject>DNA polymerase</subject><subject>DNA, Viral - chemistry</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>glycoprotein B</subject><subject>Herpesviridae - genetics</subject><subject>Herpesviridae - isolation & purification</subject><subject>Herpesviridae Infections - veterinary</subject><subject>Herpesviridae Infections - virology</subject><subject>herpesvirus</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Pan troglodytes</subject><subject>Phylogeny</subject><subject>polymerase chain reaction</subject><subject>Polymerase Chain Reaction - veterinary</subject><subject>sanctuary</subject><subject>Sequence Alignment</subject><subject>Uganda</subject><subject>Viral Envelope Proteins - chemistry</subject><subject>Viral Envelope Proteins - genetics</subject><issn>0047-2565</issn><issn>1600-0684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQhi0EgrK8AvKNU8I43mKJC0JQdjiAerQcx6EpWUrcQOHpcWgFV3zxSP7-mfGHECYQk3COZzERABGIlMUJgIoBqBLxcgONfh820QiAySjhgu-gXe9nECim2DbaIUoBEJGO0M0pbtp3V-Gp6-bOv5dd73HZ4MXUYW8au-hN94nttKznpvlyzuO2wfcvps4MvvKVafKBfn4JhdlHW4WpvDtY33vo-eL86ewyun0YX52d3kaWcS4iKghjXKUJoanKcsaSnIMwyuZSckuzTBbAc8sLmUCRW0cMTTIJeWZ4mtrC0j10tOo779q33vmFrktvXRW2cW3vtaRUKBUGBDJdkbZrve9coeddWYcfaQJ6MKlnehCmB2F6MKl_TOpliB6uh_RZ7fK_4FpdAE5WwEdZuc9_N9bXd4-hCPFoFS_9wi1_46Z71UJSyfXkfqxhMrmW6d2N5vQbbMqQMw</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Mugisha, L.</creator><creator>Leendertz, F.H.</creator><creator>Opuda-Asibo, J.</creator><creator>Olobo, J.O.</creator><creator>Ehlers, B.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201002</creationdate><title>A novel herpesvirus in the sanctuary chimpanzees on Ngamba Island in Uganda</title><author>Mugisha, L. ; Leendertz, F.H. ; Opuda-Asibo, J. ; Olobo, J.O. ; Ehlers, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4556-3614459821389bd442d506a9cd775c3bb7f05dc5f720fdce1a32b70dba588cfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Animals, Zoo</topic><topic>Ape Diseases - virology</topic><topic>Base Sequence</topic><topic>chimpanzee</topic><topic>DNA polymerase</topic><topic>DNA, Viral - chemistry</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>glycoprotein B</topic><topic>Herpesviridae - genetics</topic><topic>Herpesviridae - isolation & purification</topic><topic>Herpesviridae Infections - veterinary</topic><topic>Herpesviridae Infections - virology</topic><topic>herpesvirus</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Pan troglodytes</topic><topic>Phylogeny</topic><topic>polymerase chain reaction</topic><topic>Polymerase Chain Reaction - veterinary</topic><topic>sanctuary</topic><topic>Sequence Alignment</topic><topic>Uganda</topic><topic>Viral Envelope Proteins - chemistry</topic><topic>Viral Envelope Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mugisha, L.</creatorcontrib><creatorcontrib>Leendertz, F.H.</creatorcontrib><creatorcontrib>Opuda-Asibo, J.</creatorcontrib><creatorcontrib>Olobo, J.O.</creatorcontrib><creatorcontrib>Ehlers, B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical primatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mugisha, L.</au><au>Leendertz, F.H.</au><au>Opuda-Asibo, J.</au><au>Olobo, J.O.</au><au>Ehlers, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel herpesvirus in the sanctuary chimpanzees on Ngamba Island in Uganda</atitle><jtitle>Journal of medical primatology</jtitle><addtitle>J Med Primatol</addtitle><date>2010-02</date><risdate>2010</risdate><volume>39</volume><issue>1</issue><spage>71</spage><epage>76</epage><pages>71-76</pages><issn>0047-2565</issn><eissn>1600-0684</eissn><abstract>Background Recent studies in non‐human primates have led to the discovery of novel primate herpesviruses. In order to get more information on herpesvirus infections in apes, we studied wild born captive chimpanzees.
Methods Chimpanzees of the Ngamba island sanctuary, Uganda, were analyzed with pan‐herpes polymerase chain reaction (PCR) targeting the herpesvirus DNA polymerase gene and the glycoprotein B gene. The obtained sequences were connected by long‐distance PCR, and analyzed phylogenetically.
Results Twenty‐one of 40 individuals were infected with members of the Gammaherpesvirinae, two of them with a novel member of this subfamily. Phylogenetically, the novel virus fell into a clade of primate rhadinoviruses and the Kaposi sarcoma herpesvirus (human herpesvirus 8), representing a third distinct rhadinovirus in chimpanzees.
Conclusion Non‐human primates harbor several herpesviruses many of which are still unknown. This has implications to management of primates in sanctuaries requiring continuous updates on the management protocols to deal with potential occupational pathogens.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19900168</pmid><doi>10.1111/j.1600-0684.2009.00396.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals Animals, Zoo Ape Diseases - virology Base Sequence chimpanzee DNA polymerase DNA, Viral - chemistry DNA, Viral - genetics Female glycoprotein B Herpesviridae - genetics Herpesviridae - isolation & purification Herpesviridae Infections - veterinary Herpesviridae Infections - virology herpesvirus Male Molecular Sequence Data Pan troglodytes Phylogeny polymerase chain reaction Polymerase Chain Reaction - veterinary sanctuary Sequence Alignment Uganda Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics |
| title | A novel herpesvirus in the sanctuary chimpanzees on Ngamba Island in Uganda |
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