Contribution of itch-associated scratch behavior to the development of skin lesions in Dermatophagoides farinae-induced dermatitis model in NC/Nga mice
Recently, we have reported that the pathophysiological features of dermatitis induced by the repeated application with Dermatophagoides farinae (Df) extract ointment in NC/Nga mice were similar to those observed in the patients with atopic dermatitis. In the present study, we first examined whether...
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| Veröffentlicht in: | Archives of Dermatological Research 2009-10, Vol.301 (10), p.739-746 |
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| creator | Yamamoto, Mina Haruna, Takayo Ueda, Chihiro Asano, Yumi Takahashi, Hisashi Iduhara, Miho Takaki, Shigeki Yasui, Kiyoshi Matsuo, Yoshiyuki Arimura, Akinori |
| description | Recently, we have reported that the pathophysiological features of dermatitis induced by the repeated application with Dermatophagoides farinae (Df) extract ointment in NC/Nga mice were similar to those observed in the patients with atopic dermatitis. In the present study, we first examined whether the application of Df in other mouse strains could induce dermatitis. The repeated application of Df body (Dfb) ointment to the barrier-disrupted back of ICR, C57BL/6, and Balb/c mice did not cause any apparent skin lesions, although transient increase in serum immunoglobulin E (IgE) levels during antigen application was observed. On the other hand, in NC/Nga mice, dermatitis scores and serum IgE levels increased remarkably, and then these changes sustained for at least 10 days after stopping of antigen elicitation. Using NC/Nga mice, we investigated the contribution of scratching behavior to the development and maintenance of Dfb-induced dermatitis. In correlation with the increase in scratching behavior, erythema, hemorrhage, edema, scarring, erosion and excoriation were observed. Cutting off the hind toenails of mice exhibiting chronic skin lesions dramatically alleviated the dermatitis. From these findings, the onset of skin lesions and its chronically sustained course in Dfb-induced dermatitis in NC/Nga mice were closely associated with increased scratching behavior. |
| doi_str_mv | 10.1007/s00403-008-0912-8 |
| format | Article |
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In the present study, we first examined whether the application of Df in other mouse strains could induce dermatitis. The repeated application of Df body (Dfb) ointment to the barrier-disrupted back of ICR, C57BL/6, and Balb/c mice did not cause any apparent skin lesions, although transient increase in serum immunoglobulin E (IgE) levels during antigen application was observed. On the other hand, in NC/Nga mice, dermatitis scores and serum IgE levels increased remarkably, and then these changes sustained for at least 10 days after stopping of antigen elicitation. Using NC/Nga mice, we investigated the contribution of scratching behavior to the development and maintenance of Dfb-induced dermatitis. In correlation with the increase in scratching behavior, erythema, hemorrhage, edema, scarring, erosion and excoriation were observed. Cutting off the hind toenails of mice exhibiting chronic skin lesions dramatically alleviated the dermatitis. From these findings, the onset of skin lesions and its chronically sustained course in Dfb-induced dermatitis in NC/Nga mice were closely associated with increased scratching behavior.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-008-0912-8</identifier><identifier>PMID: 18979107</identifier><identifier>CODEN: ADREDL</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Allergic diseases ; Animals ; Antigens, Dermatophagoides - administration & dosage ; Antigens, Dermatophagoides - immunology ; Biological and medical sciences ; Cell Extracts - administration & dosage ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - physiopathology ; Dermatology ; Dermatophagoides ; Dermatophagoides farinae ; Dermatophagoides farinae - immunology ; Disease Models, Animal ; Disease Progression ; Female ; Immunization ; Immunoglobulin E - blood ; Immunoglobulin E - genetics ; Immunoglobulin E - immunology ; Immunopathology ; Medical sciences ; Medicine ; Medicine & Public Health ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Original Paper ; Pruritus ; Skin - immunology ; Skin - metabolism ; Skin - pathology ; Skin allergic diseases. Stinging insect allergies</subject><ispartof>Archives of Dermatological Research, 2009-10, Vol.301 (10), p.739-746</ispartof><rights>Springer-Verlag 2008</rights><rights>2009 INIST-CNRS</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-74bf4c6dcbdaabf2007f70b6f994bf21ddee52aae36a1c05cdd7f79c5cdfd673</citedby><cites>FETCH-LOGICAL-c521t-74bf4c6dcbdaabf2007f70b6f994bf21ddee52aae36a1c05cdd7f79c5cdfd673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-008-0912-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-008-0912-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21985263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18979107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Mina</creatorcontrib><creatorcontrib>Haruna, Takayo</creatorcontrib><creatorcontrib>Ueda, Chihiro</creatorcontrib><creatorcontrib>Asano, Yumi</creatorcontrib><creatorcontrib>Takahashi, Hisashi</creatorcontrib><creatorcontrib>Iduhara, Miho</creatorcontrib><creatorcontrib>Takaki, Shigeki</creatorcontrib><creatorcontrib>Yasui, Kiyoshi</creatorcontrib><creatorcontrib>Matsuo, Yoshiyuki</creatorcontrib><creatorcontrib>Arimura, Akinori</creatorcontrib><title>Contribution of itch-associated scratch behavior to the development of skin lesions in Dermatophagoides farinae-induced dermatitis model in NC/Nga mice</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>Recently, we have reported that the pathophysiological features of dermatitis induced by the repeated application with Dermatophagoides farinae (Df) extract ointment in NC/Nga mice were similar to those observed in the patients with atopic dermatitis. In the present study, we first examined whether the application of Df in other mouse strains could induce dermatitis. The repeated application of Df body (Dfb) ointment to the barrier-disrupted back of ICR, C57BL/6, and Balb/c mice did not cause any apparent skin lesions, although transient increase in serum immunoglobulin E (IgE) levels during antigen application was observed. On the other hand, in NC/Nga mice, dermatitis scores and serum IgE levels increased remarkably, and then these changes sustained for at least 10 days after stopping of antigen elicitation. Using NC/Nga mice, we investigated the contribution of scratching behavior to the development and maintenance of Dfb-induced dermatitis. In correlation with the increase in scratching behavior, erythema, hemorrhage, edema, scarring, erosion and excoriation were observed. Cutting off the hind toenails of mice exhibiting chronic skin lesions dramatically alleviated the dermatitis. From these findings, the onset of skin lesions and its chronically sustained course in Dfb-induced dermatitis in NC/Nga mice were closely associated with increased scratching behavior.</description><subject>Allergic diseases</subject><subject>Animals</subject><subject>Antigens, Dermatophagoides - administration & dosage</subject><subject>Antigens, Dermatophagoides - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Extracts - administration & dosage</subject><subject>Dermatitis, Atopic - blood</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Atopic - physiopathology</subject><subject>Dermatology</subject><subject>Dermatophagoides</subject><subject>Dermatophagoides farinae</subject><subject>Dermatophagoides farinae - immunology</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Immunization</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - genetics</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Original Paper</subject><subject>Pruritus</subject><subject>Skin - immunology</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin allergic diseases. 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Stinging insect allergies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Mina</creatorcontrib><creatorcontrib>Haruna, Takayo</creatorcontrib><creatorcontrib>Ueda, Chihiro</creatorcontrib><creatorcontrib>Asano, Yumi</creatorcontrib><creatorcontrib>Takahashi, Hisashi</creatorcontrib><creatorcontrib>Iduhara, Miho</creatorcontrib><creatorcontrib>Takaki, Shigeki</creatorcontrib><creatorcontrib>Yasui, Kiyoshi</creatorcontrib><creatorcontrib>Matsuo, Yoshiyuki</creatorcontrib><creatorcontrib>Arimura, Akinori</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Mina</au><au>Haruna, Takayo</au><au>Ueda, Chihiro</au><au>Asano, Yumi</au><au>Takahashi, Hisashi</au><au>Iduhara, Miho</au><au>Takaki, Shigeki</au><au>Yasui, Kiyoshi</au><au>Matsuo, Yoshiyuki</au><au>Arimura, Akinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of itch-associated scratch behavior to the development of skin lesions in Dermatophagoides farinae-induced dermatitis model in NC/Nga mice</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>301</volume><issue>10</issue><spage>739</spage><epage>746</epage><pages>739-746</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><coden>ADREDL</coden><abstract>Recently, we have reported that the pathophysiological features of dermatitis induced by the repeated application with Dermatophagoides farinae (Df) extract ointment in NC/Nga mice were similar to those observed in the patients with atopic dermatitis. In the present study, we first examined whether the application of Df in other mouse strains could induce dermatitis. The repeated application of Df body (Dfb) ointment to the barrier-disrupted back of ICR, C57BL/6, and Balb/c mice did not cause any apparent skin lesions, although transient increase in serum immunoglobulin E (IgE) levels during antigen application was observed. On the other hand, in NC/Nga mice, dermatitis scores and serum IgE levels increased remarkably, and then these changes sustained for at least 10 days after stopping of antigen elicitation. Using NC/Nga mice, we investigated the contribution of scratching behavior to the development and maintenance of Dfb-induced dermatitis. In correlation with the increase in scratching behavior, erythema, hemorrhage, edema, scarring, erosion and excoriation were observed. Cutting off the hind toenails of mice exhibiting chronic skin lesions dramatically alleviated the dermatitis. From these findings, the onset of skin lesions and its chronically sustained course in Dfb-induced dermatitis in NC/Nga mice were closely associated with increased scratching behavior.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>18979107</pmid><doi>10.1007/s00403-008-0912-8</doi><tpages>8</tpages></addata></record> |
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| ispartof | Archives of Dermatological Research, 2009-10, Vol.301 (10), p.739-746 |
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| subjects | Allergic diseases Animals Antigens, Dermatophagoides - administration & dosage Antigens, Dermatophagoides - immunology Biological and medical sciences Cell Extracts - administration & dosage Dermatitis, Atopic - blood Dermatitis, Atopic - immunology Dermatitis, Atopic - physiopathology Dermatology Dermatophagoides Dermatophagoides farinae Dermatophagoides farinae - immunology Disease Models, Animal Disease Progression Female Immunization Immunoglobulin E - blood Immunoglobulin E - genetics Immunoglobulin E - immunology Immunopathology Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Inbred C57BL Original Paper Pruritus Skin - immunology Skin - metabolism Skin - pathology Skin allergic diseases. Stinging insect allergies |
| title | Contribution of itch-associated scratch behavior to the development of skin lesions in Dermatophagoides farinae-induced dermatitis model in NC/Nga mice |
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