Effects of ovarian failure on submucosal collagen and blood vessels of the anal canal in postmenopausal women
Background Estrogen and progesterone receptors are expressed in the anal canal. Fecal control deteriorates after menopause. This phenomenon is related to decreased circulating levels of estrogen and progesterone due to ovarian failure at menopause. Aim of work To study the effects of estrogen and pr...
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| Veröffentlicht in: | International journal of colorectal disease 2010-04, Vol.25 (4), p.477-483 |
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| creator | Elbanna, Hosam Ghazy Abbas, Amr Medhat Zalata, Khaled Farid, Mohamed Ghanum, Wageh Youssef, Mohamed Thabet, Waleed Mohamed El Awady, Saleh El-Sattar, Mohamed H. Abd |
| description | Background Estrogen and progesterone receptors are expressed in the anal canal. Fecal control deteriorates after menopause. This phenomenon is related to decreased circulating levels of estrogen and progesterone due to ovarian failure at menopause. Aim of work To study the effects of estrogen and progesterone on inflammatory cells, submucosal collagen fibers, and vascular plexus of the anal canal of postmenopausal women. Subjects and methods Experiments were performed on samples of anorectal tissue obtained from 40 women, 19 menstruating (group I), and 21 postmenopausal women (group II). Investigations included immunohistochemistry of estrogen and progesterone receptors and CD34. Results In negative estrogen receptors (ER) and progesterone receptors (PR), inflammatory cells, submucosal blood vessels, collagen type I were nonsignificantly changed in postmenopausal women relative to menstruating women (P > 0.05) whereas, in positive ER and PR, inflammatory cells and collagen I were significantly increased and submucosal blood vessels were significantly decreased in postmenopausal women relative to menstruating women (P |
| doi_str_mv | 10.1007/s00384-009-0820-1 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_733696886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714486905</galeid><sourcerecordid>A714486905</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-212f90c7ee8a602318c7f6e691f43bc1381c51b75bd5650709576bcec0d3bc9d3</originalsourceid><addsrcrecordid>eNp9kVuL1TAUhYsoznH0B_iiQRGfOu6dtLk8DsN4gQEfdJ5DmibHDm1yTNoR_73p9OCgiAQSdva3VrJZVfUc4QwBxLsMwGRTA6gaJIUaH1Q7bBitkXL6sNoBClWjauVJ9STnGyg1F83j6gSVAkop31XTpffOzplET-KtSYMJxJthXJIjMZC8dNNiYzYjsXEczd4FYkJPujHGnty6nN14p52_udJYsbt9COQQ8zy5EA9mWeU_YimeVo-8GbN7djxPq-v3l18vPtZXnz98uji_qm2jcK4pUq_ACuek4UAZSis8d1yhb1hnkUm0LXai7fqWtyBAtYJ31lnoS1v17LR6u_keUvy-uDzracjWlQGCi0vWgjGuuJS8kK_-Im_iksoIWVMs3qxRskCvN2hvRqeH4OOcjF0t9bnAppFcQVuos39QZfVuGmwMzg_l_g8BbgKbYs7JeX1Iw2TST42g14D1FrAuAes1YI1F8-L435KM6-8Vx0QL8OYImGzN6JMJdsi_OUpbbKUQhaMbl0sr7F26H_x_r7_cRN5EbfapGF9_oYAMUCJSRtkvbojEzQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216503498</pqid></control><display><type>article</type><title>Effects of ovarian failure on submucosal collagen and blood vessels of the anal canal in postmenopausal women</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Elbanna, Hosam Ghazy ; Abbas, Amr Medhat ; Zalata, Khaled ; Farid, Mohamed ; Ghanum, Wageh ; Youssef, Mohamed ; Thabet, Waleed Mohamed ; El Awady, Saleh ; El-Sattar, Mohamed H. Abd</creator><creatorcontrib>Elbanna, Hosam Ghazy ; Abbas, Amr Medhat ; Zalata, Khaled ; Farid, Mohamed ; Ghanum, Wageh ; Youssef, Mohamed ; Thabet, Waleed Mohamed ; El Awady, Saleh ; El-Sattar, Mohamed H. Abd</creatorcontrib><description>Background Estrogen and progesterone receptors are expressed in the anal canal. Fecal control deteriorates after menopause. This phenomenon is related to decreased circulating levels of estrogen and progesterone due to ovarian failure at menopause. Aim of work To study the effects of estrogen and progesterone on inflammatory cells, submucosal collagen fibers, and vascular plexus of the anal canal of postmenopausal women. Subjects and methods Experiments were performed on samples of anorectal tissue obtained from 40 women, 19 menstruating (group I), and 21 postmenopausal women (group II). Investigations included immunohistochemistry of estrogen and progesterone receptors and CD34. Results In negative estrogen receptors (ER) and progesterone receptors (PR), inflammatory cells, submucosal blood vessels, collagen type I were nonsignificantly changed in postmenopausal women relative to menstruating women (P > 0.05) whereas, in positive ER and PR, inflammatory cells and collagen I were significantly increased and submucosal blood vessels were significantly decreased in postmenopausal women relative to menstruating women (P < 0.05). Conclusion Estrogen and progesterone, in menstruating women, produce beneficial effects by decreasing incidence of inflammation and increasing anal canal submucosal blood vessels number and collagen types I, thus both hormones have a positive effect on anal compliance and pressure.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-009-0820-1</identifier><identifier>PMID: 19902226</identifier><identifier>CODEN: IJCDE6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Anal Canal - blood supply ; Anal Canal - metabolism ; Anal Canal - ultrastructure ; Analysis ; Biological and medical sciences ; Blood Vessels ; Collagen ; Collagen Type I - analysis ; Estrogen ; Estrogens ; Female ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatology ; Humans ; Immunohistochemistry ; Inflammation ; Internal Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Menopause ; Original Article ; Ovary - physiopathology ; Postmenopausal women ; Postmenopause - physiology ; Proctology ; Progesterone ; Receptors, Estrogen - analysis ; Receptors, Progesterone - analysis ; Surgery</subject><ispartof>International journal of colorectal disease, 2010-04, Vol.25 (4), p.477-483</ispartof><rights>Springer-Verlag 2009</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Springer</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-212f90c7ee8a602318c7f6e691f43bc1381c51b75bd5650709576bcec0d3bc9d3</citedby><cites>FETCH-LOGICAL-c491t-212f90c7ee8a602318c7f6e691f43bc1381c51b75bd5650709576bcec0d3bc9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-009-0820-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-009-0820-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22515877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19902226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elbanna, Hosam Ghazy</creatorcontrib><creatorcontrib>Abbas, Amr Medhat</creatorcontrib><creatorcontrib>Zalata, Khaled</creatorcontrib><creatorcontrib>Farid, Mohamed</creatorcontrib><creatorcontrib>Ghanum, Wageh</creatorcontrib><creatorcontrib>Youssef, Mohamed</creatorcontrib><creatorcontrib>Thabet, Waleed Mohamed</creatorcontrib><creatorcontrib>El Awady, Saleh</creatorcontrib><creatorcontrib>El-Sattar, Mohamed H. Abd</creatorcontrib><title>Effects of ovarian failure on submucosal collagen and blood vessels of the anal canal in postmenopausal women</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Background Estrogen and progesterone receptors are expressed in the anal canal. Fecal control deteriorates after menopause. This phenomenon is related to decreased circulating levels of estrogen and progesterone due to ovarian failure at menopause. Aim of work To study the effects of estrogen and progesterone on inflammatory cells, submucosal collagen fibers, and vascular plexus of the anal canal of postmenopausal women. Subjects and methods Experiments were performed on samples of anorectal tissue obtained from 40 women, 19 menstruating (group I), and 21 postmenopausal women (group II). Investigations included immunohistochemistry of estrogen and progesterone receptors and CD34. Results In negative estrogen receptors (ER) and progesterone receptors (PR), inflammatory cells, submucosal blood vessels, collagen type I were nonsignificantly changed in postmenopausal women relative to menstruating women (P > 0.05) whereas, in positive ER and PR, inflammatory cells and collagen I were significantly increased and submucosal blood vessels were significantly decreased in postmenopausal women relative to menstruating women (P < 0.05). Conclusion Estrogen and progesterone, in menstruating women, produce beneficial effects by decreasing incidence of inflammation and increasing anal canal submucosal blood vessels number and collagen types I, thus both hormones have a positive effect on anal compliance and pressure.</description><subject>Anal Canal - blood supply</subject><subject>Anal Canal - metabolism</subject><subject>Anal Canal - ultrastructure</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Blood Vessels</subject><subject>Collagen</subject><subject>Collagen Type I - analysis</subject><subject>Estrogen</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Original Article</subject><subject>Ovary - physiopathology</subject><subject>Postmenopausal women</subject><subject>Postmenopause - physiology</subject><subject>Proctology</subject><subject>Progesterone</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Surgery</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kVuL1TAUhYsoznH0B_iiQRGfOu6dtLk8DsN4gQEfdJ5DmibHDm1yTNoR_73p9OCgiAQSdva3VrJZVfUc4QwBxLsMwGRTA6gaJIUaH1Q7bBitkXL6sNoBClWjauVJ9STnGyg1F83j6gSVAkop31XTpffOzplET-KtSYMJxJthXJIjMZC8dNNiYzYjsXEczd4FYkJPujHGnty6nN14p52_udJYsbt9COQQ8zy5EA9mWeU_YimeVo-8GbN7djxPq-v3l18vPtZXnz98uji_qm2jcK4pUq_ACuek4UAZSis8d1yhb1hnkUm0LXai7fqWtyBAtYJ31lnoS1v17LR6u_keUvy-uDzracjWlQGCi0vWgjGuuJS8kK_-Im_iksoIWVMs3qxRskCvN2hvRqeH4OOcjF0t9bnAppFcQVuos39QZfVuGmwMzg_l_g8BbgKbYs7JeX1Iw2TST42g14D1FrAuAes1YI1F8-L435KM6-8Vx0QL8OYImGzN6JMJdsi_OUpbbKUQhaMbl0sr7F26H_x_r7_cRN5EbfapGF9_oYAMUCJSRtkvbojEzQ</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Elbanna, Hosam Ghazy</creator><creator>Abbas, Amr Medhat</creator><creator>Zalata, Khaled</creator><creator>Farid, Mohamed</creator><creator>Ghanum, Wageh</creator><creator>Youssef, Mohamed</creator><creator>Thabet, Waleed Mohamed</creator><creator>El Awady, Saleh</creator><creator>El-Sattar, Mohamed H. Abd</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Effects of ovarian failure on submucosal collagen and blood vessels of the anal canal in postmenopausal women</title><author>Elbanna, Hosam Ghazy ; Abbas, Amr Medhat ; Zalata, Khaled ; Farid, Mohamed ; Ghanum, Wageh ; Youssef, Mohamed ; Thabet, Waleed Mohamed ; El Awady, Saleh ; El-Sattar, Mohamed H. Abd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-212f90c7ee8a602318c7f6e691f43bc1381c51b75bd5650709576bcec0d3bc9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anal Canal - blood supply</topic><topic>Anal Canal - metabolism</topic><topic>Anal Canal - ultrastructure</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Blood Vessels</topic><topic>Collagen</topic><topic>Collagen Type I - analysis</topic><topic>Estrogen</topic><topic>Estrogens</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Original Article</topic><topic>Ovary - physiopathology</topic><topic>Postmenopausal women</topic><topic>Postmenopause - physiology</topic><topic>Proctology</topic><topic>Progesterone</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elbanna, Hosam Ghazy</creatorcontrib><creatorcontrib>Abbas, Amr Medhat</creatorcontrib><creatorcontrib>Zalata, Khaled</creatorcontrib><creatorcontrib>Farid, Mohamed</creatorcontrib><creatorcontrib>Ghanum, Wageh</creatorcontrib><creatorcontrib>Youssef, Mohamed</creatorcontrib><creatorcontrib>Thabet, Waleed Mohamed</creatorcontrib><creatorcontrib>El Awady, Saleh</creatorcontrib><creatorcontrib>El-Sattar, Mohamed H. Abd</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elbanna, Hosam Ghazy</au><au>Abbas, Amr Medhat</au><au>Zalata, Khaled</au><au>Farid, Mohamed</au><au>Ghanum, Wageh</au><au>Youssef, Mohamed</au><au>Thabet, Waleed Mohamed</au><au>El Awady, Saleh</au><au>El-Sattar, Mohamed H. Abd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ovarian failure on submucosal collagen and blood vessels of the anal canal in postmenopausal women</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>25</volume><issue>4</issue><spage>477</spage><epage>483</epage><pages>477-483</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><coden>IJCDE6</coden><abstract>Background Estrogen and progesterone receptors are expressed in the anal canal. Fecal control deteriorates after menopause. This phenomenon is related to decreased circulating levels of estrogen and progesterone due to ovarian failure at menopause. Aim of work To study the effects of estrogen and progesterone on inflammatory cells, submucosal collagen fibers, and vascular plexus of the anal canal of postmenopausal women. Subjects and methods Experiments were performed on samples of anorectal tissue obtained from 40 women, 19 menstruating (group I), and 21 postmenopausal women (group II). Investigations included immunohistochemistry of estrogen and progesterone receptors and CD34. Results In negative estrogen receptors (ER) and progesterone receptors (PR), inflammatory cells, submucosal blood vessels, collagen type I were nonsignificantly changed in postmenopausal women relative to menstruating women (P > 0.05) whereas, in positive ER and PR, inflammatory cells and collagen I were significantly increased and submucosal blood vessels were significantly decreased in postmenopausal women relative to menstruating women (P < 0.05). Conclusion Estrogen and progesterone, in menstruating women, produce beneficial effects by decreasing incidence of inflammation and increasing anal canal submucosal blood vessels number and collagen types I, thus both hormones have a positive effect on anal compliance and pressure.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>19902226</pmid><doi>10.1007/s00384-009-0820-1</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0179-1958 |
| ispartof | International journal of colorectal disease, 2010-04, Vol.25 (4), p.477-483 |
| issn | 0179-1958 1432-1262 |
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| subjects | Anal Canal - blood supply Anal Canal - metabolism Anal Canal - ultrastructure Analysis Biological and medical sciences Blood Vessels Collagen Collagen Type I - analysis Estrogen Estrogens Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Immunohistochemistry Inflammation Internal Medicine Medical sciences Medicine Medicine & Public Health Menopause Original Article Ovary - physiopathology Postmenopausal women Postmenopause - physiology Proctology Progesterone Receptors, Estrogen - analysis Receptors, Progesterone - analysis Surgery |
| title | Effects of ovarian failure on submucosal collagen and blood vessels of the anal canal in postmenopausal women |
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