LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4

The bioactive phospholipid, lysophosphatidic acid (LPA), acting through at least five distinct receptors LPA1–LPA5, plays important roles in numerous biological processes. Here we report that LPA induces osteoblastic differentiation of human mesenchymal stem cells hMSC‐TERT. We find that hMSC‐TERT m...

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Veröffentlicht in:	Journal of cellular biochemistry 2010-03, Vol.109 (4), p.794-800
Hauptverfasser:	Liu, Yao-Bin, Kharode, Yogendra, Bodine, Peter V.N., Yaworsky, Paul J., Robinson, John A., Billiard, Julia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone (trabecular) Bone and Bones Calcium Calcium - analysis Cell Differentiation - drug effects Cells, Cultured Cyclic AMP Cyclic AMP - analysis differentiation Humans LPA LPA receptors Lysophosphatidic acid Lysophospholipids - pharmacology Mesenchymal Stem Cells - cytology Mesenchyme Mice Mice, Knockout Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - drug effects Osteogenesis Phospholipids Receptors, Lysophosphatidic Acid - metabolism Receptors, Purinergic - metabolism Signal transduction Stem cells
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