Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction
In this comparative-effectiveness trial, biventricular pacing prevented the reduction in left ventricular ejection fraction that is seen with right ventricular pacing. The deleterious effect of nonphysiologic right ventricular apical pacing on left ventricular systolic function has been recognized s...
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| Veröffentlicht in: | The New England journal of medicine 2009-11, Vol.361 (22), p.2123-2134 |
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| container_title | The New England journal of medicine |
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| creator | Yu, Cheuk-Man Chan, Hamish Chi-Kin Chan, Joseph Yat-Sun Zhang, Qing Omar, Razali Yip, Gabriel Wai-Kwok Hussin, Azlan Fang, Fang Lam, Kai Huat Fung, Jeffrey Wing-Hong |
| description | In this comparative-effectiveness trial, biventricular pacing prevented the reduction in left ventricular ejection fraction that is seen with right ventricular pacing.
The deleterious effect of nonphysiologic right ventricular apical pacing on left ventricular systolic function has been recognized since the 1920s.
1
In the Dual Chamber and VVI Implantable Defibrillator (DAVID) trial, the unexpected increased rates of death and hospital admission for heart failure among patients who were randomly assigned to the dual-chamber, rate-adaptive (DDDR) mode were purportedly due to the adverse effect of right ventricular apical pacing on left ventricular structural remodeling.
2
Results of subsequent trials have supported the notion that right ventricular apical pacing might lead to adverse clinical outcomes in patients with standard pacing indications.
3
–
7
Nevertheless, right ventricular . . . |
| doi_str_mv | 10.1056/NEJMoa0907555 |
| format | Article |
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The deleterious effect of nonphysiologic right ventricular apical pacing on left ventricular systolic function has been recognized since the 1920s.
1
In the Dual Chamber and VVI Implantable Defibrillator (DAVID) trial, the unexpected increased rates of death and hospital admission for heart failure among patients who were randomly assigned to the dual-chamber, rate-adaptive (DDDR) mode were purportedly due to the adverse effect of right ventricular apical pacing on left ventricular structural remodeling.
2
Results of subsequent trials have supported the notion that right ventricular apical pacing might lead to adverse clinical outcomes in patients with standard pacing indications.
3
–
7
Nevertheless, right ventricular . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa0907555</identifier><identifier>PMID: 19915220</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Acute coronary syndromes ; Aged ; Atrioventricular Block - complications ; Beta blockers ; Biological and medical sciences ; Bradycardia - etiology ; Bradycardia - physiopathology ; Bradycardia - therapy ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiac Pacing, Artificial - adverse effects ; Cardiac Pacing, Artificial - methods ; Cardiac Volume ; Cardiology ; Cardiology. Vascular system ; Cardiovascular system ; Double-Blind Method ; Echocardiography, Three-Dimensional ; Female ; General aspects ; Heart ; Heart attacks ; Humans ; Investigative techniques of hemodynamics ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Pacemaker, Artificial ; Prospective Studies ; Quality of Life ; Sick Sinus Syndrome - complications ; Stroke Volume ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - prevention & control ; Ventricular Dysfunction, Left - therapy ; Ventricular Function, Left ; Ventricular Remodeling</subject><ispartof>The New England journal of medicine, 2009-11, Vol.361 (22), p.2123-2134</ispartof><rights>Copyright © 2009 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><rights>2009 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-cd6b3becbda72184316c62cdf24d85b6f8b7503af62bb7cf8b4dccacad525cf33</citedby><cites>FETCH-LOGICAL-c457t-cd6b3becbda72184316c62cdf24d85b6f8b7503af62bb7cf8b4dccacad525cf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa0907555$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa0907555$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22175815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19915220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Cheuk-Man</creatorcontrib><creatorcontrib>Chan, Hamish Chi-Kin</creatorcontrib><creatorcontrib>Chan, Joseph Yat-Sun</creatorcontrib><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Omar, Razali</creatorcontrib><creatorcontrib>Yip, Gabriel Wai-Kwok</creatorcontrib><creatorcontrib>Hussin, Azlan</creatorcontrib><creatorcontrib>Fang, Fang</creatorcontrib><creatorcontrib>Lam, Kai Huat</creatorcontrib><creatorcontrib>Fung, Jeffrey Wing-Hong</creatorcontrib><title>Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this comparative-effectiveness trial, biventricular pacing prevented the reduction in left ventricular ejection fraction that is seen with right ventricular pacing.
The deleterious effect of nonphysiologic right ventricular apical pacing on left ventricular systolic function has been recognized since the 1920s.
1
In the Dual Chamber and VVI Implantable Defibrillator (DAVID) trial, the unexpected increased rates of death and hospital admission for heart failure among patients who were randomly assigned to the dual-chamber, rate-adaptive (DDDR) mode were purportedly due to the adverse effect of right ventricular apical pacing on left ventricular structural remodeling.
2
Results of subsequent trials have supported the notion that right ventricular apical pacing might lead to adverse clinical outcomes in patients with standard pacing indications.
3
–
7
Nevertheless, right ventricular . . .</description><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Atrioventricular Block - complications</subject><subject>Beta blockers</subject><subject>Biological and medical sciences</subject><subject>Bradycardia - etiology</subject><subject>Bradycardia - physiopathology</subject><subject>Bradycardia - therapy</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiac Pacing, Artificial - adverse effects</subject><subject>Cardiac Pacing, Artificial - methods</subject><subject>Cardiac Volume</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Double-Blind Method</subject><subject>Echocardiography, Three-Dimensional</subject><subject>Female</subject><subject>General aspects</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Investigative techniques of hemodynamics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pacemaker, Artificial</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Sick Sinus Syndrome - complications</subject><subject>Stroke Volume</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - prevention & control</subject><subject>Ventricular Dysfunction, Left - therapy</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Remodeling</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10E1P3DAQBmALUcFCe-RaRUiop7QeO3aSI6Dlo4JtD-05mowd8CpxqJ2A-Pd1YQUqEr54RvNobL2MHQD_Clzpb6vl9-sRec1LpdQWW4CSMi8KrrfZgnNR5UVZy122F-OapwNFvcN2oa5BCcEXbHXi7q2fgqO5x5D9RHL-JnM-VZNLg5g9uOk2OwloHgmDcZihN9lqDAP22XJtaXKjz84CPhUf2YcO-2g_be599vts-ev0Ir_6cX55enyVU6HKKSejW9laag2WAqpCgiYtyHSiMJVqdVe1peISOy3atqTUFoYICY0Sijop99mX5713Yfwz2zg1g4tk-x69HefYlFLqWgJAkodv5Hqcg0-fa4SQNYCGOqH8GVEYYwy2a-6CGzA8NsCbfzE3_8Wc_OfN0rkdrHnVm1wTONoAjIR9F9CTiy9OCChVBerVDUNsvF0P7zz4FxGkkM4</recordid><startdate>20091126</startdate><enddate>20091126</enddate><creator>Yu, Cheuk-Man</creator><creator>Chan, Hamish Chi-Kin</creator><creator>Chan, Joseph Yat-Sun</creator><creator>Zhang, Qing</creator><creator>Omar, Razali</creator><creator>Yip, Gabriel Wai-Kwok</creator><creator>Hussin, Azlan</creator><creator>Fang, Fang</creator><creator>Lam, Kai Huat</creator><creator>Fung, Jeffrey Wing-Hong</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20091126</creationdate><title>Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction</title><author>Yu, Cheuk-Man ; Chan, Hamish Chi-Kin ; Chan, Joseph Yat-Sun ; Zhang, Qing ; Omar, Razali ; Yip, Gabriel Wai-Kwok ; Hussin, Azlan ; Fang, Fang ; Lam, Kai Huat ; Fung, Jeffrey Wing-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-cd6b3becbda72184316c62cdf24d85b6f8b7503af62bb7cf8b4dccacad525cf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Atrioventricular Block - complications</topic><topic>Beta blockers</topic><topic>Biological and medical sciences</topic><topic>Bradycardia - etiology</topic><topic>Bradycardia - physiopathology</topic><topic>Bradycardia - therapy</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiac Pacing, Artificial - adverse effects</topic><topic>Cardiac Pacing, Artificial - methods</topic><topic>Cardiac Volume</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Double-Blind Method</topic><topic>Echocardiography, Three-Dimensional</topic><topic>Female</topic><topic>General aspects</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Investigative techniques of hemodynamics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pacemaker, Artificial</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Sick Sinus Syndrome - complications</topic><topic>Stroke Volume</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - prevention & control</topic><topic>Ventricular Dysfunction, Left - therapy</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Cheuk-Man</creatorcontrib><creatorcontrib>Chan, Hamish Chi-Kin</creatorcontrib><creatorcontrib>Chan, Joseph Yat-Sun</creatorcontrib><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Omar, Razali</creatorcontrib><creatorcontrib>Yip, Gabriel Wai-Kwok</creatorcontrib><creatorcontrib>Hussin, Azlan</creatorcontrib><creatorcontrib>Fang, Fang</creatorcontrib><creatorcontrib>Lam, Kai Huat</creatorcontrib><creatorcontrib>Fung, Jeffrey Wing-Hong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Cheuk-Man</au><au>Chan, Hamish Chi-Kin</au><au>Chan, Joseph Yat-Sun</au><au>Zhang, Qing</au><au>Omar, Razali</au><au>Yip, Gabriel Wai-Kwok</au><au>Hussin, Azlan</au><au>Fang, Fang</au><au>Lam, Kai Huat</au><au>Fung, Jeffrey Wing-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2009-11-26</date><risdate>2009</risdate><volume>361</volume><issue>22</issue><spage>2123</spage><epage>2134</epage><pages>2123-2134</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In this comparative-effectiveness trial, biventricular pacing prevented the reduction in left ventricular ejection fraction that is seen with right ventricular pacing.
The deleterious effect of nonphysiologic right ventricular apical pacing on left ventricular systolic function has been recognized since the 1920s.
1
In the Dual Chamber and VVI Implantable Defibrillator (DAVID) trial, the unexpected increased rates of death and hospital admission for heart failure among patients who were randomly assigned to the dual-chamber, rate-adaptive (DDDR) mode were purportedly due to the adverse effect of right ventricular apical pacing on left ventricular structural remodeling.
2
Results of subsequent trials have supported the notion that right ventricular apical pacing might lead to adverse clinical outcomes in patients with standard pacing indications.
3
–
7
Nevertheless, right ventricular . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>19915220</pmid><doi>10.1056/NEJMoa0907555</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2009-11, Vol.361 (22), p.2123-2134 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733693111 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine Current |
| subjects | Acute coronary syndromes Aged Atrioventricular Block - complications Beta blockers Biological and medical sciences Bradycardia - etiology Bradycardia - physiopathology Bradycardia - therapy Cardiac arrhythmia Cardiac dysrhythmias Cardiac Pacing, Artificial - adverse effects Cardiac Pacing, Artificial - methods Cardiac Volume Cardiology Cardiology. Vascular system Cardiovascular system Double-Blind Method Echocardiography, Three-Dimensional Female General aspects Heart Heart attacks Humans Investigative techniques of hemodynamics Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Pacemaker, Artificial Prospective Studies Quality of Life Sick Sinus Syndrome - complications Stroke Volume Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - prevention & control Ventricular Dysfunction, Left - therapy Ventricular Function, Left Ventricular Remodeling |
| title | Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction |
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