Ovarian cancer tumor infiltrating T-regulatory (Treg ) cells are associated with a metastatic phenotype

Abstract Objective The objective of this study was to examine the clinicopathologic correlates of T-regulatory (Treg ) cell infiltration in serous ovarian cancers and to define gene signatures associated with high Treg s. Methods Tumor infiltrating Treg and cytotoxic T-cells (CTLs) were quantitated...

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Veröffentlicht in:	Gynecologic oncology 2010-03, Vol.116 (3), p.556-562
Hauptverfasser:	Barnett, Jason C, Bean, Sarah M, Whitaker, Regina S, Kondoh, Eiji, Baba, Tsukasa, Fujii, Shingo, Marks, Jeffrey R, Dressman, Holly K, Murphy, Susan K, Berchuck, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigen Presentation Female Gene Expression - immunology Hematology, Oncology and Palliative Medicine Humans Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Middle Aged Neoplasm Metastasis Obstetrics and Gynecology Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Phenotype T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Tumor infiltrating lymphocytes Young Adult
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