Fatty Acid Profile Comparisons in Human Milk Sampled From the Same Mothers at the Sixth Week and the Sixth Month of Lactation
ABSTRACT Objectives: To compare fatty acid composition of human milk at 2 different stages of lactation and investigate the relation between trans isomeric and long‐chain polyunsaturated fatty acids (LCPUFAs) in human milk at the sixth month of lactation. Subjects and Methods: We investigated human...
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2010-03, Vol.50 (3), p.316-320 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 320 |
|---|---|
| container_issue | 3 |
| container_start_page | 316 |
| container_title | Journal of pediatric gastroenterology and nutrition |
| container_volume | 50 |
| creator | Szabó, Éva Boehm, Günther Beermann, Christopher Weyermann, Maria Brenner, Hermann Rothenbacher, Dietrich Decsi, Tamás |
| description | ABSTRACT
Objectives:
To compare fatty acid composition of human milk at 2 different stages of lactation and investigate the relation between trans isomeric and long‐chain polyunsaturated fatty acids (LCPUFAs) in human milk at the sixth month of lactation.
Subjects and Methods:
We investigated human milk samples obtained at the sixth week and sixth month of lactation from 462 mothers who participated in a large birth cohort study. Fatty acid composition of human milk lipids was determined by high‐resolution capillary gas‐liquid chromatography.
Results:
Fat contents of human milk increased significantly between the sixth week and sixth month of lactation (1.63 [2.06] and 3.19 [3.14], g/100 mL; median [interquartile range], P < 0.001). Percentage contributions to human milk fatty acid composition of nearly all polyunsaturated fatty acids also increased significantly (linoleic acid: 10.09 [4.41] and 11.01 [4.53], arachidonic acid: 0.46 [0.32] and 0.48 [0.23], α‐linolenic acid: 0.69 [0.42] and 0.75 [0.41], and docosahexaenoic acid: 0.17 [0.23] and 0.23 [0.15], % wt/wt, P < 0.001). Values of the 18‐carbon trans octadecenoic acid (C18:1n‐7/9t) significantly inversely correlated to linoleic acid (r = −0.24, P < 0.001), α‐linolenic acid (r = −0.19, P < 0.001), and arachidonic acid (r = −0.43, P < 0.001). In contrast, we found no correlation between the 16‐carbon trans hexadecenoic acid (C16:1n‐7t) and the same LCPUFAs.
Conclusions:
Data obtained in the present study indicate increasing fat contents with stable or increasing percentage contribution of LCPUFAs in human milk samples between the sixth week and at the sixth month of lactation, and the availability of 18‐carbon trans isomeric fatty acids is inversely associated to the availability of several LCPUFAs in human milk at the sixth month of lactation. |
| doi_str_mv | 10.1097/MPG.0b013e3181a9f944 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733689303</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733689303</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4854-ae20331db2143c5cc79a7cb6f1010ca745cc49e13895e7dc1832ffd2a562c3e43</originalsourceid><addsrcrecordid>eNqNkcFv0zAYxS0EYl3hP0DIF8Qpw46dxDlwGBXdmFqotCGO0Vfni2rqxJ3taPSw_x1P7QBxgYttPf2ev-dnQl5xdsZZXb1bri7O2JpxgYIrDnVXS_mETHghykwqxp-SCcurKss5L0_IaQjfGWOVLNhzcpIzzpViakLu5xDjnp5r09KVd52xSGeu34E3wQ2BmoFejj0MdGnsll5Dv7PY0rl3PY0bfBCQLl06-kAhHjTzI27oN8QthaH9Q1q6Ia2uowvQEaJxwwvyrAMb8OVxn5Kv8483s8ts8eXi0-x8kWmpCpkB5kwI3q5zLoUutK5qqPS67DjjTEN6lNayRi5UXWDVaq5E3nVtDkWZa4FSTMnbw707725HDLHpTdBoLQzoxtBUQpSqFmnIlMgDqb0LwWPX7Lzpwe8bzpqH3pvUe_N378n2-jhgXPfY_jI9Fp2AN0cAggbbeRi0Cb-5XMqKpwhTog7cnbMxlbq14x36ZoNg4-ZfGd4frekT9_-Vu7lafRYf5qwQUomf3L6wIQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733689303</pqid></control><display><type>article</type><title>Fatty Acid Profile Comparisons in Human Milk Sampled From the Same Mothers at the Sixth Week and the Sixth Month of Lactation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>Szabó, Éva ; Boehm, Günther ; Beermann, Christopher ; Weyermann, Maria ; Brenner, Hermann ; Rothenbacher, Dietrich ; Decsi, Tamás</creator><creatorcontrib>Szabó, Éva ; Boehm, Günther ; Beermann, Christopher ; Weyermann, Maria ; Brenner, Hermann ; Rothenbacher, Dietrich ; Decsi, Tamás</creatorcontrib><description>ABSTRACT
Objectives:
To compare fatty acid composition of human milk at 2 different stages of lactation and investigate the relation between trans isomeric and long‐chain polyunsaturated fatty acids (LCPUFAs) in human milk at the sixth month of lactation.
Subjects and Methods:
We investigated human milk samples obtained at the sixth week and sixth month of lactation from 462 mothers who participated in a large birth cohort study. Fatty acid composition of human milk lipids was determined by high‐resolution capillary gas‐liquid chromatography.
Results:
Fat contents of human milk increased significantly between the sixth week and sixth month of lactation (1.63 [2.06] and 3.19 [3.14], g/100 mL; median [interquartile range], P < 0.001). Percentage contributions to human milk fatty acid composition of nearly all polyunsaturated fatty acids also increased significantly (linoleic acid: 10.09 [4.41] and 11.01 [4.53], arachidonic acid: 0.46 [0.32] and 0.48 [0.23], α‐linolenic acid: 0.69 [0.42] and 0.75 [0.41], and docosahexaenoic acid: 0.17 [0.23] and 0.23 [0.15], % wt/wt, P < 0.001). Values of the 18‐carbon trans octadecenoic acid (C18:1n‐7/9t) significantly inversely correlated to linoleic acid (r = −0.24, P < 0.001), α‐linolenic acid (r = −0.19, P < 0.001), and arachidonic acid (r = −0.43, P < 0.001). In contrast, we found no correlation between the 16‐carbon trans hexadecenoic acid (C16:1n‐7t) and the same LCPUFAs.
Conclusions:
Data obtained in the present study indicate increasing fat contents with stable or increasing percentage contribution of LCPUFAs in human milk samples between the sixth week and at the sixth month of lactation, and the availability of 18‐carbon trans isomeric fatty acids is inversely associated to the availability of several LCPUFAs in human milk at the sixth month of lactation.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0b013e3181a9f944</identifier><identifier>PMID: 20118808</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; arachidonic acid ; Biological and medical sciences ; docosahexaenoic acid ; Fats - analysis ; Fatty Acids - analysis ; Fatty Acids, Unsaturated - analysis ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Lactation ; long‐chain polyunsaturated fatty acids ; Milk, Human - chemistry ; Mothers ; trans fatty acids ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Young Adult</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2010-03, Vol.50 (3), p.316-320</ispartof><rights>2010 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2010 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4854-ae20331db2143c5cc79a7cb6f1010ca745cc49e13895e7dc1832ffd2a562c3e43</citedby><cites>FETCH-LOGICAL-c4854-ae20331db2143c5cc79a7cb6f1010ca745cc49e13895e7dc1832ffd2a562c3e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0b013e3181a9f944$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0b013e3181a9f944$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22447189$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20118808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szabó, Éva</creatorcontrib><creatorcontrib>Boehm, Günther</creatorcontrib><creatorcontrib>Beermann, Christopher</creatorcontrib><creatorcontrib>Weyermann, Maria</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><creatorcontrib>Rothenbacher, Dietrich</creatorcontrib><creatorcontrib>Decsi, Tamás</creatorcontrib><title>Fatty Acid Profile Comparisons in Human Milk Sampled From the Same Mothers at the Sixth Week and the Sixth Month of Lactation</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objectives:
To compare fatty acid composition of human milk at 2 different stages of lactation and investigate the relation between trans isomeric and long‐chain polyunsaturated fatty acids (LCPUFAs) in human milk at the sixth month of lactation.
Subjects and Methods:
We investigated human milk samples obtained at the sixth week and sixth month of lactation from 462 mothers who participated in a large birth cohort study. Fatty acid composition of human milk lipids was determined by high‐resolution capillary gas‐liquid chromatography.
Results:
Fat contents of human milk increased significantly between the sixth week and sixth month of lactation (1.63 [2.06] and 3.19 [3.14], g/100 mL; median [interquartile range], P < 0.001). Percentage contributions to human milk fatty acid composition of nearly all polyunsaturated fatty acids also increased significantly (linoleic acid: 10.09 [4.41] and 11.01 [4.53], arachidonic acid: 0.46 [0.32] and 0.48 [0.23], α‐linolenic acid: 0.69 [0.42] and 0.75 [0.41], and docosahexaenoic acid: 0.17 [0.23] and 0.23 [0.15], % wt/wt, P < 0.001). Values of the 18‐carbon trans octadecenoic acid (C18:1n‐7/9t) significantly inversely correlated to linoleic acid (r = −0.24, P < 0.001), α‐linolenic acid (r = −0.19, P < 0.001), and arachidonic acid (r = −0.43, P < 0.001). In contrast, we found no correlation between the 16‐carbon trans hexadecenoic acid (C16:1n‐7t) and the same LCPUFAs.
Conclusions:
Data obtained in the present study indicate increasing fat contents with stable or increasing percentage contribution of LCPUFAs in human milk samples between the sixth week and at the sixth month of lactation, and the availability of 18‐carbon trans isomeric fatty acids is inversely associated to the availability of several LCPUFAs in human milk at the sixth month of lactation.</description><subject>Adult</subject><subject>arachidonic acid</subject><subject>Biological and medical sciences</subject><subject>docosahexaenoic acid</subject><subject>Fats - analysis</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids, Unsaturated - analysis</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lactation</subject><subject>long‐chain polyunsaturated fatty acids</subject><subject>Milk, Human - chemistry</subject><subject>Mothers</subject><subject>trans fatty acids</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Young Adult</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFv0zAYxS0EYl3hP0DIF8Qpw46dxDlwGBXdmFqotCGO0Vfni2rqxJ3taPSw_x1P7QBxgYttPf2ev-dnQl5xdsZZXb1bri7O2JpxgYIrDnVXS_mETHghykwqxp-SCcurKss5L0_IaQjfGWOVLNhzcpIzzpViakLu5xDjnp5r09KVd52xSGeu34E3wQ2BmoFejj0MdGnsll5Dv7PY0rl3PY0bfBCQLl06-kAhHjTzI27oN8QthaH9Q1q6Ia2uowvQEaJxwwvyrAMb8OVxn5Kv8483s8ts8eXi0-x8kWmpCpkB5kwI3q5zLoUutK5qqPS67DjjTEN6lNayRi5UXWDVaq5E3nVtDkWZa4FSTMnbw707725HDLHpTdBoLQzoxtBUQpSqFmnIlMgDqb0LwWPX7Lzpwe8bzpqH3pvUe_N378n2-jhgXPfY_jI9Fp2AN0cAggbbeRi0Cb-5XMqKpwhTog7cnbMxlbq14x36ZoNg4-ZfGd4frekT9_-Vu7lafRYf5qwQUomf3L6wIQ</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>Szabó, Éva</creator><creator>Boehm, Günther</creator><creator>Beermann, Christopher</creator><creator>Weyermann, Maria</creator><creator>Brenner, Hermann</creator><creator>Rothenbacher, Dietrich</creator><creator>Decsi, Tamás</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201003</creationdate><title>Fatty Acid Profile Comparisons in Human Milk Sampled From the Same Mothers at the Sixth Week and the Sixth Month of Lactation</title><author>Szabó, Éva ; Boehm, Günther ; Beermann, Christopher ; Weyermann, Maria ; Brenner, Hermann ; Rothenbacher, Dietrich ; Decsi, Tamás</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4854-ae20331db2143c5cc79a7cb6f1010ca745cc49e13895e7dc1832ffd2a562c3e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>arachidonic acid</topic><topic>Biological and medical sciences</topic><topic>docosahexaenoic acid</topic><topic>Fats - analysis</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids, Unsaturated - analysis</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lactation</topic><topic>long‐chain polyunsaturated fatty acids</topic><topic>Milk, Human - chemistry</topic><topic>Mothers</topic><topic>trans fatty acids</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szabó, Éva</creatorcontrib><creatorcontrib>Boehm, Günther</creatorcontrib><creatorcontrib>Beermann, Christopher</creatorcontrib><creatorcontrib>Weyermann, Maria</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><creatorcontrib>Rothenbacher, Dietrich</creatorcontrib><creatorcontrib>Decsi, Tamás</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szabó, Éva</au><au>Boehm, Günther</au><au>Beermann, Christopher</au><au>Weyermann, Maria</au><au>Brenner, Hermann</au><au>Rothenbacher, Dietrich</au><au>Decsi, Tamás</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatty Acid Profile Comparisons in Human Milk Sampled From the Same Mothers at the Sixth Week and the Sixth Month of Lactation</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2010-03</date><risdate>2010</risdate><volume>50</volume><issue>3</issue><spage>316</spage><epage>320</epage><pages>316-320</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objectives:
To compare fatty acid composition of human milk at 2 different stages of lactation and investigate the relation between trans isomeric and long‐chain polyunsaturated fatty acids (LCPUFAs) in human milk at the sixth month of lactation.
Subjects and Methods:
We investigated human milk samples obtained at the sixth week and sixth month of lactation from 462 mothers who participated in a large birth cohort study. Fatty acid composition of human milk lipids was determined by high‐resolution capillary gas‐liquid chromatography.
Results:
Fat contents of human milk increased significantly between the sixth week and sixth month of lactation (1.63 [2.06] and 3.19 [3.14], g/100 mL; median [interquartile range], P < 0.001). Percentage contributions to human milk fatty acid composition of nearly all polyunsaturated fatty acids also increased significantly (linoleic acid: 10.09 [4.41] and 11.01 [4.53], arachidonic acid: 0.46 [0.32] and 0.48 [0.23], α‐linolenic acid: 0.69 [0.42] and 0.75 [0.41], and docosahexaenoic acid: 0.17 [0.23] and 0.23 [0.15], % wt/wt, P < 0.001). Values of the 18‐carbon trans octadecenoic acid (C18:1n‐7/9t) significantly inversely correlated to linoleic acid (r = −0.24, P < 0.001), α‐linolenic acid (r = −0.19, P < 0.001), and arachidonic acid (r = −0.43, P < 0.001). In contrast, we found no correlation between the 16‐carbon trans hexadecenoic acid (C16:1n‐7t) and the same LCPUFAs.
Conclusions:
Data obtained in the present study indicate increasing fat contents with stable or increasing percentage contribution of LCPUFAs in human milk samples between the sixth week and at the sixth month of lactation, and the availability of 18‐carbon trans isomeric fatty acids is inversely associated to the availability of several LCPUFAs in human milk at the sixth month of lactation.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>20118808</pmid><doi>10.1097/MPG.0b013e3181a9f944</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 2010-03, Vol.50 (3), p.316-320 |
| issn | 0277-2116 1536-4801 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733689303 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Adult arachidonic acid Biological and medical sciences docosahexaenoic acid Fats - analysis Fatty Acids - analysis Fatty Acids, Unsaturated - analysis Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Lactation long‐chain polyunsaturated fatty acids Milk, Human - chemistry Mothers trans fatty acids Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult |
| title | Fatty Acid Profile Comparisons in Human Milk Sampled From the Same Mothers at the Sixth Week and the Sixth Month of Lactation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T23%3A38%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fatty%20Acid%20Profile%20Comparisons%20in%20Human%20Milk%20Sampled%20From%20the%20Same%20Mothers%20at%20the%20Sixth%20Week%20and%20the%20Sixth%20Month%20of%20Lactation&rft.jtitle=Journal%20of%20pediatric%20gastroenterology%20and%20nutrition&rft.au=Szab%C3%B3,%20%C3%89va&rft.date=2010-03&rft.volume=50&rft.issue=3&rft.spage=316&rft.epage=320&rft.pages=316-320&rft.issn=0277-2116&rft.eissn=1536-4801&rft.coden=JPGND6&rft_id=info:doi/10.1097/MPG.0b013e3181a9f944&rft_dat=%3Cproquest_cross%3E733689303%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733689303&rft_id=info:pmid/20118808&rfr_iscdi=true |