Reduction/Dissolution of a β-MnOOH Nanophase in the Ferritin Cavity To Yield a Highly Sensitive, Biologically Compatible Magnetic Resonance Imaging Agent

Reduction/Dissolution of a β-MnOOH Nanophase in the Ferritin Cavity To Yield a Highly Sensitive, Biologically Compatible Magnetic Resonance Imaging Agent

A manganese‐based contrast agent for magnetic resonance imaging has been obtained by partial reduction/dissolution of solid β‐MnOOH inside the cavity of apoferritin (see scheme). The resulting nanocarriers contain up to 300–400 MnII aqua ions and have a remarkable relaxivity of 4000–7000 mM−1 s−1 pe...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-01, Vol.49 (3), p.612-615
Hauptverfasser: Kálmán, Ferenc Krisztián, Geninatti-Crich, Simonetta, Aime, Silvio
Format: Artikel
Sprache:eng
Schlagworte:
Apoferritins - chemistry
contrast agents
Contrast Media - chemistry
Ferritins - chemistry
imaging agents
Magnetic Resonance Imaging
manganese
Manganese - chemistry
Microscopy, Electron, Transmission
Oxidation-Reduction
Oxides - chemistry
proteins
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Zusammenfassung:A manganese‐based contrast agent for magnetic resonance imaging has been obtained by partial reduction/dissolution of solid β‐MnOOH inside the cavity of apoferritin (see scheme). The resulting nanocarriers contain up to 300–400 MnII aqua ions and have a remarkable relaxivity of 4000–7000 mM−1 s−1 per apoferritin unit.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200904731