Pycnogenol® treatment of acute hemorrhoidal episodes
We investigated the efficacy of orally and topically applied Pycnogenol® for the management of acute hemorrhoidal attacks in a controlled, randomized study with 84 subjects. Within less than 48 h of onset of an acute attack, patients were enrolled and signs and symptoms were scored. This evaluation...
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| Veröffentlicht in: | Phytotherapy research 2010-03, Vol.24 (3), p.438-444 |
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| creator | Belcaro, Gianni Cesarone, Maria Rosaria Errichi, Bruno Di Renzo, Andrea Grossi, Maria Giovanna Ricci, Andrea Dugall, Mark Cornelli, Umberto Cacchio, Marisa Rohdewald, Peter |
| description | We investigated the efficacy of orally and topically applied Pycnogenol® for the management of acute hemorrhoidal attacks in a controlled, randomized study with 84 subjects. Within less than 48 h of onset of an acute attack, patients were enrolled and signs and symptoms were scored. This evaluation was repeated after seven days' treatment and again seven days following treatment cessation. The decrease in scores was significantly more pronounced in the Pycnogenol®-treated groups than in the control group given placebo (p < 0.05), showing the efficacy of Pycnogenol® for relieving signs and symptoms of acute external hemorrhoids. In a group of patients given topical (0.5%) Pycnogenol® in addition to oral Pycnogenol® the improvement in symptoms set in significantly faster and was more pronounced. The most prominent symptom, hemorrhoidal bleeding, was completely absent in all patients treated with Pycnogenol® for seven days and also at the 14 days follow-up. In contrast, bleedings were still observed in the control group during the two weeks follow-up. This study indicates that Pycnogenol®, both in oral and in topical form, is effective for controlling this common, disabling health problem. The application of Pycnogenol® eases the management of acute hemorrhoidal attacks and help avoid bleedings. Copyright © 2009 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.3021 |
| format | Article |
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Within less than 48 h of onset of an acute attack, patients were enrolled and signs and symptoms were scored. This evaluation was repeated after seven days' treatment and again seven days following treatment cessation. The decrease in scores was significantly more pronounced in the Pycnogenol®-treated groups than in the control group given placebo (p < 0.05), showing the efficacy of Pycnogenol® for relieving signs and symptoms of acute external hemorrhoids. In a group of patients given topical (0.5%) Pycnogenol® in addition to oral Pycnogenol® the improvement in symptoms set in significantly faster and was more pronounced. The most prominent symptom, hemorrhoidal bleeding, was completely absent in all patients treated with Pycnogenol® for seven days and also at the 14 days follow-up. In contrast, bleedings were still observed in the control group during the two weeks follow-up. This study indicates that Pycnogenol®, both in oral and in topical form, is effective for controlling this common, disabling health problem. The application of Pycnogenol® eases the management of acute hemorrhoidal attacks and help avoid bleedings. Copyright © 2009 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.3021</identifier><identifier>PMID: 20041428</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Administration, Cutaneous ; Administration, Oral ; Adult ; Biological and medical sciences ; Cost of Illness ; Female ; Flavonoids - economics ; Flavonoids - therapeutic use ; General pharmacology ; hemorrhoidal bleeding ; hemorrhoids ; Hemorrhoids - drug therapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Pain Measurement ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Pycnogenol ; Quality of Life ; venous insufficiency</subject><ispartof>Phytotherapy research, 2010-03, Vol.24 (3), p.438-444</ispartof><rights>Copyright © 2009 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2009 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4121-6b00183b6dbb6dae17a545b49a7b545720ff7233a4eba43784804407c903cf843</citedby><cites>FETCH-LOGICAL-c4121-6b00183b6dbb6dae17a545b49a7b545720ff7233a4eba43784804407c903cf843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.3021$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.3021$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22409808$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20041428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belcaro, Gianni</creatorcontrib><creatorcontrib>Cesarone, Maria Rosaria</creatorcontrib><creatorcontrib>Errichi, Bruno</creatorcontrib><creatorcontrib>Di Renzo, Andrea</creatorcontrib><creatorcontrib>Grossi, Maria Giovanna</creatorcontrib><creatorcontrib>Ricci, Andrea</creatorcontrib><creatorcontrib>Dugall, Mark</creatorcontrib><creatorcontrib>Cornelli, Umberto</creatorcontrib><creatorcontrib>Cacchio, Marisa</creatorcontrib><creatorcontrib>Rohdewald, Peter</creatorcontrib><title>Pycnogenol® treatment of acute hemorrhoidal episodes</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>We investigated the efficacy of orally and topically applied Pycnogenol® for the management of acute hemorrhoidal attacks in a controlled, randomized study with 84 subjects. Within less than 48 h of onset of an acute attack, patients were enrolled and signs and symptoms were scored. This evaluation was repeated after seven days' treatment and again seven days following treatment cessation. The decrease in scores was significantly more pronounced in the Pycnogenol®-treated groups than in the control group given placebo (p < 0.05), showing the efficacy of Pycnogenol® for relieving signs and symptoms of acute external hemorrhoids. In a group of patients given topical (0.5%) Pycnogenol® in addition to oral Pycnogenol® the improvement in symptoms set in significantly faster and was more pronounced. The most prominent symptom, hemorrhoidal bleeding, was completely absent in all patients treated with Pycnogenol® for seven days and also at the 14 days follow-up. In contrast, bleedings were still observed in the control group during the two weeks follow-up. This study indicates that Pycnogenol®, both in oral and in topical form, is effective for controlling this common, disabling health problem. The application of Pycnogenol® eases the management of acute hemorrhoidal attacks and help avoid bleedings. Copyright © 2009 John Wiley & Sons, Ltd.</description><subject>Administration, Cutaneous</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cost of Illness</subject><subject>Female</subject><subject>Flavonoids - economics</subject><subject>Flavonoids - therapeutic use</subject><subject>General pharmacology</subject><subject>hemorrhoidal bleeding</subject><subject>hemorrhoids</subject><subject>Hemorrhoids - drug therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain Measurement</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Pycnogenol</subject><subject>Quality of Life</subject><subject>venous insufficiency</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1u1DAQB3ALFdFtQeoTQC6oXLIdfyROjtVCF0RFK2jVqhdr4p20oUm82FmVfSkegifDqw3tqQdr5vDzjPU3YwccphxAHC0HP5Ug-As24VCWKc-03GETKDOeKl5c77K9EH4CQClAvWK7AkBxJYoJy87Xtne31Lv2759k8IRDR_2QuDpBuxoouaPOeX_nmgW2CS2b4BYUXrOXNbaB3ox1n12efLqYfU5Pz-ZfZsenqVVc8DSvAHghq3xRxYPENWYqq1SJuoqNFlDXWkiJiipUUheqAKVA2xKkrQsl99nhdu7Su18rCoPpmmCpbbEntwpGS5nHS0pE-WErrXcheKrN0jcd-rXhYDYZmZiR2WQU6dtx6KrqaPEI_4cSwfsRYLDY1h5724QnJxSUBWxcunUPTUvrZxea84vv4-LRN2Gg348e_b3JtdSZufo2N19n87yAG2k-Rv9u62t0Bm99fMPlDwFcxlDjTwol_wFeRJRI</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>Belcaro, Gianni</creator><creator>Cesarone, Maria Rosaria</creator><creator>Errichi, Bruno</creator><creator>Di Renzo, Andrea</creator><creator>Grossi, Maria Giovanna</creator><creator>Ricci, Andrea</creator><creator>Dugall, Mark</creator><creator>Cornelli, Umberto</creator><creator>Cacchio, Marisa</creator><creator>Rohdewald, Peter</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201003</creationdate><title>Pycnogenol® treatment of acute hemorrhoidal episodes</title><author>Belcaro, Gianni ; Cesarone, Maria Rosaria ; Errichi, Bruno ; Di Renzo, Andrea ; Grossi, Maria Giovanna ; Ricci, Andrea ; Dugall, Mark ; Cornelli, Umberto ; Cacchio, Marisa ; Rohdewald, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4121-6b00183b6dbb6dae17a545b49a7b545720ff7233a4eba43784804407c903cf843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Cutaneous</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cost of Illness</topic><topic>Female</topic><topic>Flavonoids - economics</topic><topic>Flavonoids - therapeutic use</topic><topic>General pharmacology</topic><topic>hemorrhoidal bleeding</topic><topic>hemorrhoids</topic><topic>Hemorrhoids - drug therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain Measurement</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Pycnogenol</topic><topic>Quality of Life</topic><topic>venous insufficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belcaro, Gianni</creatorcontrib><creatorcontrib>Cesarone, Maria Rosaria</creatorcontrib><creatorcontrib>Errichi, Bruno</creatorcontrib><creatorcontrib>Di Renzo, Andrea</creatorcontrib><creatorcontrib>Grossi, Maria Giovanna</creatorcontrib><creatorcontrib>Ricci, Andrea</creatorcontrib><creatorcontrib>Dugall, Mark</creatorcontrib><creatorcontrib>Cornelli, Umberto</creatorcontrib><creatorcontrib>Cacchio, Marisa</creatorcontrib><creatorcontrib>Rohdewald, Peter</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belcaro, Gianni</au><au>Cesarone, Maria Rosaria</au><au>Errichi, Bruno</au><au>Di Renzo, Andrea</au><au>Grossi, Maria Giovanna</au><au>Ricci, Andrea</au><au>Dugall, Mark</au><au>Cornelli, Umberto</au><au>Cacchio, Marisa</au><au>Rohdewald, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pycnogenol® treatment of acute hemorrhoidal episodes</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. 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In a group of patients given topical (0.5%) Pycnogenol® in addition to oral Pycnogenol® the improvement in symptoms set in significantly faster and was more pronounced. The most prominent symptom, hemorrhoidal bleeding, was completely absent in all patients treated with Pycnogenol® for seven days and also at the 14 days follow-up. In contrast, bleedings were still observed in the control group during the two weeks follow-up. This study indicates that Pycnogenol®, both in oral and in topical form, is effective for controlling this common, disabling health problem. The application of Pycnogenol® eases the management of acute hemorrhoidal attacks and help avoid bleedings. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>20041428</pmid><doi>10.1002/ptr.3021</doi><tpages>7</tpages></addata></record> |
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| subjects | Administration, Cutaneous Administration, Oral Adult Biological and medical sciences Cost of Illness Female Flavonoids - economics Flavonoids - therapeutic use General pharmacology hemorrhoidal bleeding hemorrhoids Hemorrhoids - drug therapy Humans Male Medical sciences Middle Aged Pain Measurement Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Pycnogenol Quality of Life venous insufficiency |
| title | Pycnogenol® treatment of acute hemorrhoidal episodes |
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