The tyrosine phosphatase, SHP-1, is involved in bronchial mucin production during oxidative stress

Mucus hypersecretion is a clinically important manifestation of chronic inflammatory airway diseases, such as asthma and Chronic obstructive pulmonary disease (COPD). Mucin production in airway epithelia is increased under conditions of oxidative stress. Src homology 2 domain-containing protein tyro...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-02, Vol.393 (1), p.137-143
Hauptverfasser:	Jang, Min Kyoung, Kim, Sae-Hoon, Lee, Ki-Young, Kim, Tae-Bum, Moon, Keun Ae, Park, Chan Sun, Bae, Yun Jeong, Zhu, Zhou, Moon, Hee-Bom, Cho, You Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma Bronchi - drug effects Bronchi - enzymology Cell Line, Tumor Gene Expression Regulation Gene Knockdown Techniques Humans Hydrogen Peroxide - pharmacology Mice Mice, Inbred Strains Mucin Mucin 5AC - biosynthesis Mucin 5AC - genetics Mucus - secretion Oxidative Stress p38 Mitogen-Activated Protein Kinases - biosynthesis Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism SHP-1
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