Safety and Efficacy of an Inhaled Epidermal Growth Factor Receptor Inhibitor (BIBW 2948 BS) in Chronic Obstructive Pulmonary Disease

Epidermal growth factor receptor (EGFR) activation is implicated in mucin hypersecretion in chronic obstructive pulmonary disease (COPD). To investigate the safety and efficacy of an inhaled EGFR antagonist (BIBW 2948) in COPD. Multicenter, double-blind, placebo-controlled trial of 4 weeks of treatm...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2010-03, Vol.181 (5), p.438-445
Hauptverfasser:	Woodruff, Prescott G, Wolff, Michael, Hohlfeld, Jens M, Krug, Norbert, Dransfield, Mark T, Sutherland, E. Rand, Criner, Gerard J, Kim, Victor, Prasse, Antje, Nivens, Michael C, Tetzlaff, Kay, Heilker, Ralf, Fahy, John V
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biopsy Bronchoscopy Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Double-Blind Method Epidermal growth factor Epidermal Growth Factor - metabolism Female Forced Expiratory Volume - drug effects Gene expression Humans Intensive care medicine Kinases Lavage Male Medical sciences Middle Aged Mucins - secretion Pneumology Pulmonary Disease, Chronic Obstructive - drug therapy Receptor, Epidermal Growth Factor - antagonists & inhibitors Treatment Outcome
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