Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells

Absent in melanoma 2 (AIM2) is a member of the interferon‐inducible HIN‐200 protein family. Recent findings point to a role of AIM2 function in both inflammation and cancer. In response to foreign cytoplasmic DNA, AIM2 forms an inflammasome, resulting in caspase activation in inflammatory cells. Mor...

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Veröffentlicht in:	International journal of cancer 2010-04, Vol.126 (8), p.1838-1849
Hauptverfasser:	Patsos, Georgios, Germann, Anja, Gebert, Johannes, Dihlmann, Susanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences cell adhesion Cell Adhesion - genetics cell cycle Cell Cycle - genetics Cell Division Cell Line, Tumor Cell Proliferation colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Dermatology DNA-Binding Proteins G2 Phase Gene Expression Gene Expression Regulation, Neoplastic HIN‐200 Humans invasion Medical sciences Neoplasm Invasiveness - genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - physiology Transfection Tumors Tumors of the skin and soft tissue. Premalignant lesions
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