Blockade effects of BIBN4096BS on CGRP-induced inhibition on whole-cell K+ currents in spinal dorsal horn neuron of rats
Calcitonin gene-related peptide (CGRP) plays an important role in the transmission and modulation of nociceptive information in the spinal cord. BIBN4096BS, a nonpeptide CGRP receptor antagonist, has been shown to be efficiency in clinical migraine treatment. The present study was performed to inves...
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| Veröffentlicht in: | Neuroscience letters 2010-01, Vol.469 (1), p.15-18 |
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| creator | Hou, Jun-Feng Yu, Long-Chuan |
| description | Calcitonin gene-related peptide (CGRP) plays an important role in the transmission and modulation of nociceptive information in the spinal cord. BIBN4096BS, a nonpeptide CGRP receptor antagonist, has been shown to be efficiency in clinical migraine treatment. The present study was performed to investigate the effects of BIBN4096BS on the CGRP-induced inhibition to whole-cell K+ currents in spinal wide dynamic range (WDR) neuron of rats. Application of BIBN4096BS inhibited the neuronal activity of WDR neurons in lumbar dorsal horn of the spinal cord in rats tested by extracellular recording method. Furthermore, CGRP induced inhibition on whole-cell K+ currents in cultured dorsal horn neurons of rats tested by whole-cell patch-clamp recording, and the effect was significantly blocked by BIBN4096BS. The results indicate that BIBN4096BS may produce antinociceptive effects at the spinal level in rats. |
| doi_str_mv | 10.1016/j.neulet.2009.11.035 |
| format | Article |
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BIBN4096BS, a nonpeptide CGRP receptor antagonist, has been shown to be efficiency in clinical migraine treatment. The present study was performed to investigate the effects of BIBN4096BS on the CGRP-induced inhibition to whole-cell K+ currents in spinal wide dynamic range (WDR) neuron of rats. Application of BIBN4096BS inhibited the neuronal activity of WDR neurons in lumbar dorsal horn of the spinal cord in rats tested by extracellular recording method. Furthermore, CGRP induced inhibition on whole-cell K+ currents in cultured dorsal horn neurons of rats tested by whole-cell patch-clamp recording, and the effect was significantly blocked by BIBN4096BS. The results indicate that BIBN4096BS may produce antinociceptive effects at the spinal level in rats.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2009.11.035</identifier><identifier>PMID: 19925849</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Animals, Newborn ; BIBN4096BS ; Biological and medical sciences ; Calcitonin gene-related peptide (CGRP) ; Calcitonin Gene-Related Peptide Receptor Antagonists ; Cells, Cultured ; Cultured dorsal horn neuron ; Fundamental and applied biological sciences. Psychology ; Lumbosacral Region ; Male ; Patch-Clamp Techniques ; Piperazines - pharmacology ; Posterior Horn Cells - drug effects ; Posterior Horn Cells - physiology ; Potassium Channel Blockers - pharmacology ; Potassium Channels - physiology ; Quinazolines - pharmacology ; Rats ; Rats, Wistar ; Receptors, Calcitonin Gene-Related Peptide - physiology ; Spinal cord ; Vertebrates: nervous system and sense organs ; Whole-cell K+ current ; Wide dynamic range (WDR) neuron</subject><ispartof>Neuroscience letters, 2010-01, Vol.469 (1), p.15-18</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2009 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-f270ce582d3387422929d3f4d18a13edc5057ffb641e99d7e499e08c2fb1ec803</citedby><cites>FETCH-LOGICAL-c391t-f270ce582d3387422929d3f4d18a13edc5057ffb641e99d7e499e08c2fb1ec803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2009.11.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22341084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19925849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Jun-Feng</creatorcontrib><creatorcontrib>Yu, Long-Chuan</creatorcontrib><title>Blockade effects of BIBN4096BS on CGRP-induced inhibition on whole-cell K+ currents in spinal dorsal horn neuron of rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Calcitonin gene-related peptide (CGRP) plays an important role in the transmission and modulation of nociceptive information in the spinal cord. BIBN4096BS, a nonpeptide CGRP receptor antagonist, has been shown to be efficiency in clinical migraine treatment. The present study was performed to investigate the effects of BIBN4096BS on the CGRP-induced inhibition to whole-cell K+ currents in spinal wide dynamic range (WDR) neuron of rats. Application of BIBN4096BS inhibited the neuronal activity of WDR neurons in lumbar dorsal horn of the spinal cord in rats tested by extracellular recording method. Furthermore, CGRP induced inhibition on whole-cell K+ currents in cultured dorsal horn neurons of rats tested by whole-cell patch-clamp recording, and the effect was significantly blocked by BIBN4096BS. The results indicate that BIBN4096BS may produce antinociceptive effects at the spinal level in rats.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>BIBN4096BS</subject><subject>Biological and medical sciences</subject><subject>Calcitonin gene-related peptide (CGRP)</subject><subject>Calcitonin Gene-Related Peptide Receptor Antagonists</subject><subject>Cells, Cultured</subject><subject>Cultured dorsal horn neuron</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lumbosacral Region</subject><subject>Male</subject><subject>Patch-Clamp Techniques</subject><subject>Piperazines - pharmacology</subject><subject>Posterior Horn Cells - drug effects</subject><subject>Posterior Horn Cells - physiology</subject><subject>Potassium Channel Blockers - pharmacology</subject><subject>Potassium Channels - physiology</subject><subject>Quinazolines - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Calcitonin Gene-Related Peptide - physiology</subject><subject>Spinal cord</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Whole-cell K+ current</subject><subject>Wide dynamic range (WDR) neuron</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoModq3-g1JyI17IjPmaneSm4C62FksVW69DNjlhs51N1mTG6r9vll30TggcCM978vIEoTNKWkro_MOmjTANMLaMENVS2hLePUMzKnvW9Kpnz9GMcCIargQ5Qa9K2RBCOtqJl-iEKsU6KdQM_V4MyT4YBxi8BzsWnDxeXC9uBVHzxR1OES-vvn9rQnSTBYdDXIdVGEO9r-dxnQZoLAwD_vIe2ylniHVFiLjsQjQDdimXOtYpR1zr5n3M42zG8hq98GYo8OY4T9GPy0_3y8_Nzder6-XHm8ZyRcfGs55Y6CRznMteMKaYctwLR6WhHJztSNd7v5oLCkq5HoRSQKRlfkXBSsJP0bvD3l1OPycoo96Gsm9sIqSp6J7zueRK0kqKA2lzKiWD17sctib_0ZTovXK90Qfleq9cU6qr8ho7Pz4wrbbg_oWOjivw9giYYs3gs4k2lL8cY1xQIkXlLg4cVB2_AmRdbIBYrYdcf0a7FP7f5Amr0KA0</recordid><startdate>20100118</startdate><enddate>20100118</enddate><creator>Hou, Jun-Feng</creator><creator>Yu, Long-Chuan</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100118</creationdate><title>Blockade effects of BIBN4096BS on CGRP-induced inhibition on whole-cell K+ currents in spinal dorsal horn neuron of rats</title><author>Hou, Jun-Feng ; Yu, Long-Chuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f270ce582d3387422929d3f4d18a13edc5057ffb641e99d7e499e08c2fb1ec803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>BIBN4096BS</topic><topic>Biological and medical sciences</topic><topic>Calcitonin gene-related peptide (CGRP)</topic><topic>Calcitonin Gene-Related Peptide Receptor Antagonists</topic><topic>Cells, Cultured</topic><topic>Cultured dorsal horn neuron</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lumbosacral Region</topic><topic>Male</topic><topic>Patch-Clamp Techniques</topic><topic>Piperazines - pharmacology</topic><topic>Posterior Horn Cells - drug effects</topic><topic>Posterior Horn Cells - physiology</topic><topic>Potassium Channel Blockers - pharmacology</topic><topic>Potassium Channels - physiology</topic><topic>Quinazolines - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Calcitonin Gene-Related Peptide - physiology</topic><topic>Spinal cord</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Whole-cell K+ current</topic><topic>Wide dynamic range (WDR) neuron</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Jun-Feng</creatorcontrib><creatorcontrib>Yu, Long-Chuan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Jun-Feng</au><au>Yu, Long-Chuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blockade effects of BIBN4096BS on CGRP-induced inhibition on whole-cell K+ currents in spinal dorsal horn neuron of rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2010-01-18</date><risdate>2010</risdate><volume>469</volume><issue>1</issue><spage>15</spage><epage>18</epage><pages>15-18</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Calcitonin gene-related peptide (CGRP) plays an important role in the transmission and modulation of nociceptive information in the spinal cord. BIBN4096BS, a nonpeptide CGRP receptor antagonist, has been shown to be efficiency in clinical migraine treatment. The present study was performed to investigate the effects of BIBN4096BS on the CGRP-induced inhibition to whole-cell K+ currents in spinal wide dynamic range (WDR) neuron of rats. Application of BIBN4096BS inhibited the neuronal activity of WDR neurons in lumbar dorsal horn of the spinal cord in rats tested by extracellular recording method. Furthermore, CGRP induced inhibition on whole-cell K+ currents in cultured dorsal horn neurons of rats tested by whole-cell patch-clamp recording, and the effect was significantly blocked by BIBN4096BS. The results indicate that BIBN4096BS may produce antinociceptive effects at the spinal level in rats.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19925849</pmid><doi>10.1016/j.neulet.2009.11.035</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Animals, Newborn BIBN4096BS Biological and medical sciences Calcitonin gene-related peptide (CGRP) Calcitonin Gene-Related Peptide Receptor Antagonists Cells, Cultured Cultured dorsal horn neuron Fundamental and applied biological sciences. Psychology Lumbosacral Region Male Patch-Clamp Techniques Piperazines - pharmacology Posterior Horn Cells - drug effects Posterior Horn Cells - physiology Potassium Channel Blockers - pharmacology Potassium Channels - physiology Quinazolines - pharmacology Rats Rats, Wistar Receptors, Calcitonin Gene-Related Peptide - physiology Spinal cord Vertebrates: nervous system and sense organs Whole-cell K+ current Wide dynamic range (WDR) neuron |
| title | Blockade effects of BIBN4096BS on CGRP-induced inhibition on whole-cell K+ currents in spinal dorsal horn neuron of rats |
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