Lung Metastasis Fails in MMTV-PyMT Oncomice Lacking S100A4 Due to a T-Cell Deficiency in Primary Tumors

Interactions between tumor and stroma cells are essential for the progression of cancer from its initial growth at a primary site to its metastasis to distant organs. The metastasis-stimulating protein S100A4 exerts its function as a stroma cell-derived factor. Genetic depletion of S100A4 significan...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-02, Vol.70 (3), p.936-947
Hauptverfasser:	GRUM-SCHWENSEN, Birgitte, KLINGELHÖFER, Jörg, GRIGORIAN, Mariam, ALMHOLT, Kasper, NIELSEN, Boye Schnack, LUKANIDIN, Eugene, AMBARTSUMIAN, Noona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Blotting, Western Chemokine CCL24 - metabolism Cytokines - metabolism Female Fibroblasts - metabolism Fibroblasts - pathology Granulocyte Colony-Stimulating Factor - metabolism Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunohistochemistry Immunopathology Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - secondary Male Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - virology Mammary Tumor Virus, Mouse - physiology Medical sciences Mice Mice, Knockout Pharmacology. Drug treatments Retroviridae Infections - pathology Retroviridae Infections - virology S100 Calcium-Binding Protein A4 S100 Proteins - genetics S100 Proteins - metabolism S100 Proteins - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - metabolism T-Lymphocytes - pathology Tumor Virus Infections - pathology Tumor Virus Infections - virology Tumors
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