RETRACTED: Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1

Metastasis relies on angiogenesis for tumor expansion. Tumor angiogenesis is restrained by a variety of endogenous inhibitors, including thrombospondin 1 (TSP1). The principal antiangiogenic activity of TSP1 resides in a domain containing three TSP1 repeats (3TSR), and TSP1 cleavage is regulated, in...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-02, Vol.70 (3), p.948-956
Hauptverfasser:	Lee, Yoon-Jin, Koch, Moritz, Karl, Daniel, Torres-Collado, Antoni X, Fernando, Namali T, Rothrock, Courtney, Kuruppu, Darshini, Ryeom, Sandra, Iruela-Arispe, M Luisa, Yoon, Sam S
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics ADAM Proteins - metabolism ADAMTS1 Protein Animals Binding Sites Blotting, Western Cell Line Cell Line, Tumor Cell Proliferation Endothelial Cells - metabolism Endothelial Cells - pathology Female Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - secondary Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - secondary Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Reverse Transcriptase Polymerase Chain Reaction RNA Interference Thrombospondin 1 - genetics Thrombospondin 1 - metabolism Transfection
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