Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response
In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase ar...
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| Veröffentlicht in: | Parasite immunology 2010, Vol.32 (1), p.74-78 |
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| creator | CHIUSO-MINICUCCI, F MARRA, N.M ZORZELLA-PEZAVENTO, S.F.G FRANÇA, T.G.D ISHIKAWA, L.L.W AMARANTE, M.R.V AMARANTE, A.F.T SARTORI, A |
| description | In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-γ during the acute phase was followed by IL-10 production during recovery. Together these findings show that experimental infection of Lewis rats with S. venezuelensis presents a kinetics of parasite establishment and immunity similar to that described in other models of helminthic infection. |
| doi_str_mv | 10.1111/j.1365-3024.2009.01160.x |
| format | Article |
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Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-γ during the acute phase was followed by IL-10 production during recovery. 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Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-γ during the acute phase was followed by IL-10 production during recovery. Together these findings show that experimental infection of Lewis rats with S. venezuelensis presents a kinetics of parasite establishment and immunity similar to that described in other models of helminthic infection.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Feces - parasitology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunoglobulin E - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Lewis rats</subject><subject>Parasite Egg Count</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Remission, Spontaneous</subject><subject>Strongyloides</subject><subject>Strongyloides - immunology</subject><subject>Strongyloides venezuelensis</subject><subject>Strongyloidiasis - immunology</subject><subject>Strongyloidiasis - parasitology</subject><subject>Strongyloidiasis - pathology</subject><subject>Th2 cells</subject><subject>Th2 Cells - immunology</subject><subject>Th2 Cells - metabolism</subject><subject>Th2 Cells - pathology</subject><subject>Time Factors</subject><issn>0141-9838</issn><issn>1365-3024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAQhq2Kqmxp_wL4VE4JYztfPnCoELRIi4r4OFuOMwavsvFiZ1m2v74OSzkyB89o5nnfg19CKIOcpTpZ5ExUZSaAFzkHkDkwVkH-8onM3g97ZAasYJlsRLNPvsa4AGCCV-IL2U-aggODGVncoPHPGLbUBr-kt2Pww8O2967DSJ9xwL9r7HGILlI3WDSj80Oa6Bw3aRX0mPaR6hi9cXrEjm7c-Eg1ja9G9O6R04Bx5YeI38hnq_uI39_6Abm_OL87-53N__y6PPs5z4yoC8jaWkpRWqtZI7hpK2M5s7pqpIXOVkVbFmi6tmg4t9rYuqyg7BpeaobcgOy0OCDHO99V8E9rjKNaumiw7_WAfh1VLUTV8FpCIn98SHLG64LLMoGHb-C6XWKnVsEtddiq__-YgNMdsHE9bt_vDNSUl1qoKRY1xTJppHrNS72o68uraUr6o53eaq_0Q3BR3d8mZwGsTo8oxT9tGJM_</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>CHIUSO-MINICUCCI, F</creator><creator>MARRA, N.M</creator><creator>ZORZELLA-PEZAVENTO, S.F.G</creator><creator>FRANÇA, T.G.D</creator><creator>ISHIKAWA, L.L.W</creator><creator>AMARANTE, M.R.V</creator><creator>AMARANTE, A.F.T</creator><creator>SARTORI, A</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response</title><author>CHIUSO-MINICUCCI, F ; MARRA, N.M ; ZORZELLA-PEZAVENTO, S.F.G ; FRANÇA, T.G.D ; ISHIKAWA, L.L.W ; AMARANTE, M.R.V ; AMARANTE, A.F.T ; SARTORI, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3740-b79935ffa1832cb6cf21fa689f0df64b54ecdb4822facf75605d825a1e2c09da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Feces - parasitology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunoglobulin E - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Lewis rats</topic><topic>Parasite Egg Count</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Remission, Spontaneous</topic><topic>Strongyloides</topic><topic>Strongyloides - immunology</topic><topic>Strongyloides venezuelensis</topic><topic>Strongyloidiasis - immunology</topic><topic>Strongyloidiasis - parasitology</topic><topic>Strongyloidiasis - pathology</topic><topic>Th2 cells</topic><topic>Th2 Cells - immunology</topic><topic>Th2 Cells - metabolism</topic><topic>Th2 Cells - pathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHIUSO-MINICUCCI, F</creatorcontrib><creatorcontrib>MARRA, N.M</creatorcontrib><creatorcontrib>ZORZELLA-PEZAVENTO, S.F.G</creatorcontrib><creatorcontrib>FRANÇA, T.G.D</creatorcontrib><creatorcontrib>ISHIKAWA, L.L.W</creatorcontrib><creatorcontrib>AMARANTE, M.R.V</creatorcontrib><creatorcontrib>AMARANTE, A.F.T</creatorcontrib><creatorcontrib>SARTORI, A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Parasite immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHIUSO-MINICUCCI, F</au><au>MARRA, N.M</au><au>ZORZELLA-PEZAVENTO, S.F.G</au><au>FRANÇA, T.G.D</au><au>ISHIKAWA, L.L.W</au><au>AMARANTE, M.R.V</au><au>AMARANTE, A.F.T</au><au>SARTORI, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response</atitle><jtitle>Parasite immunology</jtitle><addtitle>Parasite Immunol</addtitle><date>2010</date><risdate>2010</risdate><volume>32</volume><issue>1</issue><spage>74</spage><epage>78</epage><pages>74-78</pages><issn>0141-9838</issn><eissn>1365-3024</eissn><abstract>In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-γ during the acute phase was followed by IL-10 production during recovery. Together these findings show that experimental infection of Lewis rats with S. venezuelensis presents a kinetics of parasite establishment and immunity similar to that described in other models of helminthic infection.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>20042010</pmid><doi>10.1111/j.1365-3024.2009.01160.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute Disease Animals Feces - parasitology Female Humans Immunity, Cellular Immunoglobulin E - biosynthesis Immunoglobulin G - biosynthesis Interferon-gamma - biosynthesis Interleukin-10 - biosynthesis Lewis rats Parasite Egg Count Rats Rats, Inbred Lew Remission, Spontaneous Strongyloides Strongyloides - immunology Strongyloides venezuelensis Strongyloidiasis - immunology Strongyloidiasis - parasitology Strongyloidiasis - pathology Th2 cells Th2 Cells - immunology Th2 Cells - metabolism Th2 Cells - pathology Time Factors |
| title | Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response |
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