In Vivo Evaluation of Hydroxyapatite Nanocoating on Polyester Artificial Vascular Grafts and Possibility as Soft-Tissue Compatible Material

The efficacy of hydroxyapatite (HAp) nanocoating on polyester vascular grafts was investigated in animal experiments. The HAp nanocrystals were covalently bonded separately between hydroxyl groups on a nanocrystal and alkoxysilyl groups in γ-methacryloxypropyl triethoxysilane graft polymerized on a...

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Veröffentlicht in:ASAIO journal (1992) 2010-01, Vol.56 (1), p.61-66
Hauptverfasser: Kadono, Hiroyuki, Furuzono, Tsutomu, Masuda, Miwa, Okada, Masahiro, Ueki, Mitsuki, Takamizawa, Keiichi, Tanaka, Ryoichi, Miyatake, Kunio, Koyama, Yoshihisa, Takakuda, Kazuo
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container_end_page 66
container_issue 1
container_start_page 61
container_title ASAIO journal (1992)
container_volume 56
creator Kadono, Hiroyuki
Furuzono, Tsutomu
Masuda, Miwa
Okada, Masahiro
Ueki, Mitsuki
Takamizawa, Keiichi
Tanaka, Ryoichi
Miyatake, Kunio
Koyama, Yoshihisa
Takakuda, Kazuo
description The efficacy of hydroxyapatite (HAp) nanocoating on polyester vascular grafts was investigated in animal experiments. The HAp nanocrystals were covalently bonded separately between hydroxyl groups on a nanocrystal and alkoxysilyl groups in γ-methacryloxypropyl triethoxysilane graft polymerized on a polyester substrate. Twelve HAp-coated polyester grafts and 10 control grafts of 20, 30, or 50 mm in length were implanted in canine common carotid arteries. Serious complications or occlusions were not observed in any of the dogs after implantation. A histologic evaluation was conducted by staining with hematoxylin and eosin (HE), the von Willebrand factor (vWf), and α-smooth muscle actin (α-SMA) around the inner lumen of the grafts. The number of inflammation cells and giant cells in the HAp-coated group was significantly lower than that in the group receiving noncoated grafts (p < 0.05).
doi_str_mv 10.1097/MAT.0b013e3181c945ae
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source MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete
subjects Animals
Blood Vessel Prosthesis - adverse effects
Carotid Arteries
Coated Materials, Biocompatible - adverse effects
Coated Materials, Biocompatible - chemistry
Compliance
Dogs
Durapatite - chemistry
Inflammation - etiology
Inflammation - pathology
Materials Testing
Microscopy, Electron, Scanning
Polyesters
title In Vivo Evaluation of Hydroxyapatite Nanocoating on Polyester Artificial Vascular Grafts and Possibility as Soft-Tissue Compatible Material
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