The impact of ovarian stimulation for IVF on the developing embryo
The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1–3% of annual births. In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenou...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2010-01, Vol.139 (1), p.23-34 |
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| creator | Santos, Margarida Avo Kuijk, Ewart W Macklon, Nick S |
| description | The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1–3% of annual births. In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenous gonadotrophins to allow retrieval of multiple oocytes in a single cycle. Although ovarian stimulation has an important role in ART, it may also have detrimental effects on oogenesis, embryo quality, endometrial receptivity and perinatal outcomes. In this review, we consider the evidence for these effects and address possible underlying mechanisms. We conclude that such mechanisms are still poorly understood, and further knowledge is needed in order to increase the safety of ovarian stimulation and to reduce potential effects on embryo development and implantation, which will ultimately be translated into increased pregnancy rates and healthy offspring. |
| doi_str_mv | 10.1530/REP-09-0187 |
| format | Article |
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In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenous gonadotrophins to allow retrieval of multiple oocytes in a single cycle. Although ovarian stimulation has an important role in ART, it may also have detrimental effects on oogenesis, embryo quality, endometrial receptivity and perinatal outcomes. In this review, we consider the evidence for these effects and address possible underlying mechanisms. 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| ispartof | Reproduction (Cambridge, England), 2010-01, Vol.139 (1), p.23-34 |
| issn | 1470-1626 1741-7899 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Embryo Implantation - drug effects Embryo, Mammalian - drug effects Embryonic Development - drug effects Epigenesis, Genetic - drug effects Female Fertilization in Vitro - methods Fertilization in Vitro - statistics & numerical data Fertilization in Vitro - trends Follicle Stimulating Hormone - adverse effects Follicle Stimulating Hormone - pharmacology Follicle Stimulating Hormone - therapeutic use Humans Infertility - therapy Oocytes - drug effects Ovulation Induction - adverse effects Ovulation Induction - methods Pregnancy Pregnancy Outcome Review |
| title | The impact of ovarian stimulation for IVF on the developing embryo |
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