Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer
This Timeline article looks back over 50 years of haematopoietic stem cell transplantation as a cancer therapy, highlighting the substantial advances that have been made to increase the specificity of this treatment for cancer cells, as well as improvements in availability, safety and patient outcom...
Gespeichert in:
| Veröffentlicht in: | Nature reviews. Cancer 2010-03, Vol.10 (3), p.213-221 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 221 |
|---|---|
| container_issue | 3 |
| container_start_page | 213 |
| container_title | Nature reviews. Cancer |
| container_volume | 10 |
| creator | van den Brink, Marcel R. M Jenq, Robert R |
| description | This Timeline article looks back over 50 years of haematopoietic stem cell transplantation as a cancer therapy, highlighting the substantial advances that have been made to increase the specificity of this treatment for cancer cells, as well as improvements in availability, safety and patient outcomes.
The year 2009 marked the fiftieth anniversary of the first successful allogeneic haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the most exciting areas of research today. HSCT was the original stem cell therapy, the first cancer immune therapy and the earliest example of individualized cancer therapy. In this Timeline article we review the history of the development of HSCT and major advances made in the past 50 years. We highlight accomplishments made by researchers who continue to strive to improve outcomes for patients and increase the availability of this potentially life-saving therapy for patients with otherwise incurable malignancies. |
| doi_str_mv | 10.1038/nrc2804 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_733672401</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A220133014</galeid><sourcerecordid>A220133014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c557t-aea6f999bd10a723fab3cd74d92ef47b1541f9de8a112fdfb10eebdc1c3ecef73</originalsourceid><addsrcrecordid>eNp90l2L1DAUBuAiiruu4i9QisLqzaw5aTtpvRsWv2DBGwXvymlyMpMhTcYkFdZfb8rMjrsqkosmzZOXnuYUxVNgF8Cq9o0LkresvlecQi3qBYhle_84b76dFI9i3DIGSxDwsDjhedZWnJ0W25W1fk2OjCw3SCMmv_OGUl7GRGMpydoyBXRxZ9ElTMa7t6VxyvwwakJrfpK6JdGp0ozj5KhMGwq4uy69LiU6SeFx8UCjjfTk8Dwrvr5_9-Xy4-Lq84dPl6urhWwakRZIuNRd1w0KGApeaRwqqUStOk66FgM0NehOUYsAXCs9ACMalARZkSQtqrPi1T53F_z3iWLqRxPnr0NHfoq9qKql4DWDLM__Kzk0bHYZvvgDbv0UXK6i56KBqmvbOqOXe7RGS71x2uf_JufEfsX5HMNgVhf_UHkoGo30jrTJ7-8cOL91YENo0yZ6O803Ee_CQ90y-BgD6X4XzIjhugfWz13SH7oky-eHcqZhJHV0N22Rwes9iHnLrSn8rvfvrGd76jBNgY5ZN_u_ACBDzyY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>275139884</pqid></control><display><type>article</type><title>Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer</title><source>MEDLINE</source><source>Nature Journals Online</source><source>SpringerLink Journals - AutoHoldings</source><creator>van den Brink, Marcel R. M ; Jenq, Robert R</creator><creatorcontrib>van den Brink, Marcel R. M ; Jenq, Robert R</creatorcontrib><description>This Timeline article looks back over 50 years of haematopoietic stem cell transplantation as a cancer therapy, highlighting the substantial advances that have been made to increase the specificity of this treatment for cancer cells, as well as improvements in availability, safety and patient outcomes.
The year 2009 marked the fiftieth anniversary of the first successful allogeneic haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the most exciting areas of research today. HSCT was the original stem cell therapy, the first cancer immune therapy and the earliest example of individualized cancer therapy. In this Timeline article we review the history of the development of HSCT and major advances made in the past 50 years. We highlight accomplishments made by researchers who continue to strive to improve outcomes for patients and increase the availability of this potentially life-saving therapy for patients with otherwise incurable malignancies.</description><identifier>ISSN: 1474-175X</identifier><identifier>EISSN: 1474-1768</identifier><identifier>DOI: 10.1038/nrc2804</identifier><identifier>PMID: 20168320</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1059/2325 ; 692/700/565/545/576/1955 ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer Research ; Care and treatment ; Cell- and Tissue-Based Therapy - history ; Health aspects ; Hematopoietic Stem Cell Transplantation - history ; Hematopoietic stem cells ; History, 20th Century ; History, 21st Century ; Humans ; Immunotherapy ; Immunotherapy - history ; Neoplasms - immunology ; Neoplasms - physiopathology ; Neoplasms - therapy ; Precision Medicine - history ; timeline ; Transplantation ; Transplantation, Homologous - history</subject><ispartof>Nature reviews. Cancer, 2010-03, Vol.10 (3), p.213-221</ispartof><rights>Springer Nature Limited 2010</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-aea6f999bd10a723fab3cd74d92ef47b1541f9de8a112fdfb10eebdc1c3ecef73</citedby><cites>FETCH-LOGICAL-c557t-aea6f999bd10a723fab3cd74d92ef47b1541f9de8a112fdfb10eebdc1c3ecef73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nrc2804$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nrc2804$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>313,314,780,784,792,2727,27922,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20168320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van den Brink, Marcel R. M</creatorcontrib><creatorcontrib>Jenq, Robert R</creatorcontrib><title>Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer</title><title>Nature reviews. Cancer</title><addtitle>Nat Rev Cancer</addtitle><addtitle>Nat Rev Cancer</addtitle><description>This Timeline article looks back over 50 years of haematopoietic stem cell transplantation as a cancer therapy, highlighting the substantial advances that have been made to increase the specificity of this treatment for cancer cells, as well as improvements in availability, safety and patient outcomes.
The year 2009 marked the fiftieth anniversary of the first successful allogeneic haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the most exciting areas of research today. HSCT was the original stem cell therapy, the first cancer immune therapy and the earliest example of individualized cancer therapy. In this Timeline article we review the history of the development of HSCT and major advances made in the past 50 years. We highlight accomplishments made by researchers who continue to strive to improve outcomes for patients and increase the availability of this potentially life-saving therapy for patients with otherwise incurable malignancies.</description><subject>631/67/1059/2325</subject><subject>692/700/565/545/576/1955</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Cell- and Tissue-Based Therapy - history</subject><subject>Health aspects</subject><subject>Hematopoietic Stem Cell Transplantation - history</subject><subject>Hematopoietic stem cells</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Immunotherapy - history</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - physiopathology</subject><subject>Neoplasms - therapy</subject><subject>Precision Medicine - history</subject><subject>timeline</subject><subject>Transplantation</subject><subject>Transplantation, Homologous - history</subject><issn>1474-175X</issn><issn>1474-1768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90l2L1DAUBuAiiruu4i9QisLqzaw5aTtpvRsWv2DBGwXvymlyMpMhTcYkFdZfb8rMjrsqkosmzZOXnuYUxVNgF8Cq9o0LkresvlecQi3qBYhle_84b76dFI9i3DIGSxDwsDjhedZWnJ0W25W1fk2OjCw3SCMmv_OGUl7GRGMpydoyBXRxZ9ElTMa7t6VxyvwwakJrfpK6JdGp0ozj5KhMGwq4uy69LiU6SeFx8UCjjfTk8Dwrvr5_9-Xy4-Lq84dPl6urhWwakRZIuNRd1w0KGApeaRwqqUStOk66FgM0NehOUYsAXCs9ACMalARZkSQtqrPi1T53F_z3iWLqRxPnr0NHfoq9qKql4DWDLM__Kzk0bHYZvvgDbv0UXK6i56KBqmvbOqOXe7RGS71x2uf_JufEfsX5HMNgVhf_UHkoGo30jrTJ7-8cOL91YENo0yZ6O803Ee_CQ90y-BgD6X4XzIjhugfWz13SH7oky-eHcqZhJHV0N22Rwes9iHnLrSn8rvfvrGd76jBNgY5ZN_u_ACBDzyY</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>van den Brink, Marcel R. M</creator><creator>Jenq, Robert R</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer</title><author>van den Brink, Marcel R. M ; Jenq, Robert R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-aea6f999bd10a723fab3cd74d92ef47b1541f9de8a112fdfb10eebdc1c3ecef73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/67/1059/2325</topic><topic>692/700/565/545/576/1955</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Cell- and Tissue-Based Therapy - history</topic><topic>Health aspects</topic><topic>Hematopoietic Stem Cell Transplantation - history</topic><topic>Hematopoietic stem cells</topic><topic>History, 20th Century</topic><topic>History, 21st Century</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Immunotherapy - history</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - physiopathology</topic><topic>Neoplasms - therapy</topic><topic>Precision Medicine - history</topic><topic>timeline</topic><topic>Transplantation</topic><topic>Transplantation, Homologous - history</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van den Brink, Marcel R. M</creatorcontrib><creatorcontrib>Jenq, Robert R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van den Brink, Marcel R. M</au><au>Jenq, Robert R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer</atitle><jtitle>Nature reviews. Cancer</jtitle><stitle>Nat Rev Cancer</stitle><addtitle>Nat Rev Cancer</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>10</volume><issue>3</issue><spage>213</spage><epage>221</epage><pages>213-221</pages><issn>1474-175X</issn><eissn>1474-1768</eissn><abstract>This Timeline article looks back over 50 years of haematopoietic stem cell transplantation as a cancer therapy, highlighting the substantial advances that have been made to increase the specificity of this treatment for cancer cells, as well as improvements in availability, safety and patient outcomes.
The year 2009 marked the fiftieth anniversary of the first successful allogeneic haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the most exciting areas of research today. HSCT was the original stem cell therapy, the first cancer immune therapy and the earliest example of individualized cancer therapy. In this Timeline article we review the history of the development of HSCT and major advances made in the past 50 years. We highlight accomplishments made by researchers who continue to strive to improve outcomes for patients and increase the availability of this potentially life-saving therapy for patients with otherwise incurable malignancies.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20168320</pmid><doi>10.1038/nrc2804</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1474-175X |
| ispartof | Nature reviews. Cancer, 2010-03, Vol.10 (3), p.213-221 |
| issn | 1474-175X 1474-1768 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733672401 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 631/67/1059/2325 692/700/565/545/576/1955 Animals Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Cell- and Tissue-Based Therapy - history Health aspects Hematopoietic Stem Cell Transplantation - history Hematopoietic stem cells History, 20th Century History, 21st Century Humans Immunotherapy Immunotherapy - history Neoplasms - immunology Neoplasms - physiopathology Neoplasms - therapy Precision Medicine - history timeline Transplantation Transplantation, Homologous - history |
| title | Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T03%3A17%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allogeneic%20haematopoietic%20stem%20cell%20transplantation:%20individualized%20stem%20cell%20and%20immune%20therapy%20of%20cancer&rft.jtitle=Nature%20reviews.%20Cancer&rft.au=van%20den%20Brink,%20Marcel%20R.%20M&rft.date=2010-03-01&rft.volume=10&rft.issue=3&rft.spage=213&rft.epage=221&rft.pages=213-221&rft.issn=1474-175X&rft.eissn=1474-1768&rft_id=info:doi/10.1038/nrc2804&rft_dat=%3Cgale_proqu%3EA220133014%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=275139884&rft_id=info:pmid/20168320&rft_galeid=A220133014&rfr_iscdi=true |