Candidate Gene Study of Canine Joint Diseases
Canine osteoarthritis (OA) commonly occurs in association with articular diseases, such as hip dysplasia (HD), elbow dysplasia (ED), or cranial cruciate ligament rupture (CCLR). We hypothesized that a common genomic risk for the development of canine joint disease and canine OA would be identified b...
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| Veröffentlicht in: | The Journal of heredity 2010-01, Vol.101 (1), p.54-60 |
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| container_title | The Journal of heredity |
| container_volume | 101 |
| creator | Clements, Dylan N Short, Andrea D Barnes, Annette Kennedy, Lorna J Ferguson, John F Butterworth, Steven J Fitzpatrick, Noel Pead, Matthew Bennett, David Innes, John F Carter, Stuart D Ollier, William E.R |
| description | Canine osteoarthritis (OA) commonly occurs in association with articular diseases, such as hip dysplasia (HD), elbow dysplasia (ED), or cranial cruciate ligament rupture (CCLR). We hypothesized that a common genomic risk for the development of canine joint disease and canine OA would be identified by evaluating the allele frequencies of candidate gene single nucleotide polymorphisms (SNPs) in dogs with OA associated with different articular diseases when compared with a general population of breed-matched dogs. DNA was extracted from blood samples obtained from Labrador Retrievers and Golden Retrievers surgically treated for ED, HD, and CCLR and confirmed to have radiographic evidence of OA. One hundred and thirteen SNPs in 20 candidate genes were genotyped. No significant associations were identified for SNPs or haplotypes in the candidate genes for the diseases evaluated. The candidate gene approach for the study of genetic association is unlikely to be successful for complex canine diseases such as OA without prior trait mapping evaluation. |
| doi_str_mv | 10.1093/jhered/esp088 |
| format | Article |
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We hypothesized that a common genomic risk for the development of canine joint disease and canine OA would be identified by evaluating the allele frequencies of candidate gene single nucleotide polymorphisms (SNPs) in dogs with OA associated with different articular diseases when compared with a general population of breed-matched dogs. DNA was extracted from blood samples obtained from Labrador Retrievers and Golden Retrievers surgically treated for ED, HD, and CCLR and confirmed to have radiographic evidence of OA. One hundred and thirteen SNPs in 20 candidate genes were genotyped. No significant associations were identified for SNPs or haplotypes in the candidate genes for the diseases evaluated. The candidate gene approach for the study of genetic association is unlikely to be successful for complex canine diseases such as OA without prior trait mapping evaluation.</description><identifier>ISSN: 0022-1503</identifier><identifier>EISSN: 1465-7333</identifier><identifier>DOI: 10.1093/jhered/esp088</identifier><identifier>PMID: 19965910</identifier><identifier>CODEN: JOHEA8</identifier><language>eng</language><publisher>United States: The American Genetic Association</publisher><subject>Animals ; association ; canine ; Dogs ; Female ; gene ; Gene Frequency ; Genetic disorders ; Genetic Predisposition to Disease ; Genomics ; joint ; Joint Diseases - genetics ; Joints ; Male ; osteoarthritis ; Polymorphism, Single Nucleotide</subject><ispartof>The Journal of heredity, 2010-01, Vol.101 (1), p.54-60</ispartof><rights>The American Genetic Association. 2009. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org. 2009</rights><rights>Copyright Oxford Publishing Limited(England) Jan/Feb 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-b24c2a284d16a0067579daa4b9807c5778e7cdf6a592269d73892653295b35a33</citedby><cites>FETCH-LOGICAL-c484t-b24c2a284d16a0067579daa4b9807c5778e7cdf6a592269d73892653295b35a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19965910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clements, Dylan N</creatorcontrib><creatorcontrib>Short, Andrea D</creatorcontrib><creatorcontrib>Barnes, Annette</creatorcontrib><creatorcontrib>Kennedy, Lorna J</creatorcontrib><creatorcontrib>Ferguson, John F</creatorcontrib><creatorcontrib>Butterworth, Steven J</creatorcontrib><creatorcontrib>Fitzpatrick, Noel</creatorcontrib><creatorcontrib>Pead, Matthew</creatorcontrib><creatorcontrib>Bennett, David</creatorcontrib><creatorcontrib>Innes, John F</creatorcontrib><creatorcontrib>Carter, Stuart D</creatorcontrib><creatorcontrib>Ollier, William E.R</creatorcontrib><title>Candidate Gene Study of Canine Joint Diseases</title><title>The Journal of heredity</title><addtitle>J Hered</addtitle><description>Canine osteoarthritis (OA) commonly occurs in association with articular diseases, such as hip dysplasia (HD), elbow dysplasia (ED), or cranial cruciate ligament rupture (CCLR). We hypothesized that a common genomic risk for the development of canine joint disease and canine OA would be identified by evaluating the allele frequencies of candidate gene single nucleotide polymorphisms (SNPs) in dogs with OA associated with different articular diseases when compared with a general population of breed-matched dogs. DNA was extracted from blood samples obtained from Labrador Retrievers and Golden Retrievers surgically treated for ED, HD, and CCLR and confirmed to have radiographic evidence of OA. One hundred and thirteen SNPs in 20 candidate genes were genotyped. No significant associations were identified for SNPs or haplotypes in the candidate genes for the diseases evaluated. The candidate gene approach for the study of genetic association is unlikely to be successful for complex canine diseases such as OA without prior trait mapping evaluation.</description><subject>Animals</subject><subject>association</subject><subject>canine</subject><subject>Dogs</subject><subject>Female</subject><subject>gene</subject><subject>Gene Frequency</subject><subject>Genetic disorders</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomics</subject><subject>joint</subject><subject>Joint Diseases - genetics</subject><subject>Joints</subject><subject>Male</subject><subject>osteoarthritis</subject><subject>Polymorphism, Single Nucleotide</subject><issn>0022-1503</issn><issn>1465-7333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1LwzAYBvAgipvTo1ctHtRL3Zuk-Trq_JgyUJjC8BKyNtXOrZ1JC_rfm9Gxgwc9hfflxxPeB6FDDBcYFO3P3q2zWd_6JUi5hbo44SwWlNJt1AUgJMYMaAfteT8DAMwU7KIOVoozhaGL4oEpsyIztY3ubGmjcd1k31GVR2FfhPmhKso6ui68Nd76fbSTm7m3B-u3h15ub54Hw3j0eHc_uBzFaSKTOp6SJCWGyCTD3ABwwYTKjEmmSoJImRDSijTLuWGKEK4yQaUinFGi2JQyQ2kPnbW5S1d9NtbXelH41M7nprRV43W4jwuQZCVP_5QEE4EpTgI8-QVnVePKcIXGSmKuKJEBxS1KXeW9s7leumJh3LfGoFd167Zu3dYd_NE6tJkuwnqj1_0GcN6Cqln-m7X-u_C1_dpg4z40F1QwPZy86ofJ09WYK6JHwR-3PjeVNm-u8PplTABTwOFixjj9AXcKny4</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Clements, Dylan N</creator><creator>Short, Andrea D</creator><creator>Barnes, Annette</creator><creator>Kennedy, Lorna J</creator><creator>Ferguson, John F</creator><creator>Butterworth, Steven J</creator><creator>Fitzpatrick, Noel</creator><creator>Pead, Matthew</creator><creator>Bennett, David</creator><creator>Innes, John F</creator><creator>Carter, Stuart D</creator><creator>Ollier, William E.R</creator><general>The American Genetic Association</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SN</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Candidate Gene Study of Canine Joint Diseases</title><author>Clements, Dylan N ; Short, Andrea D ; Barnes, Annette ; Kennedy, Lorna J ; Ferguson, John F ; Butterworth, Steven J ; Fitzpatrick, Noel ; Pead, Matthew ; Bennett, David ; Innes, John F ; Carter, Stuart D ; Ollier, William E.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-b24c2a284d16a0067579daa4b9807c5778e7cdf6a592269d73892653295b35a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>association</topic><topic>canine</topic><topic>Dogs</topic><topic>Female</topic><topic>gene</topic><topic>Gene Frequency</topic><topic>Genetic disorders</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomics</topic><topic>joint</topic><topic>Joint Diseases - genetics</topic><topic>Joints</topic><topic>Male</topic><topic>osteoarthritis</topic><topic>Polymorphism, Single Nucleotide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clements, Dylan N</creatorcontrib><creatorcontrib>Short, Andrea D</creatorcontrib><creatorcontrib>Barnes, Annette</creatorcontrib><creatorcontrib>Kennedy, Lorna J</creatorcontrib><creatorcontrib>Ferguson, John F</creatorcontrib><creatorcontrib>Butterworth, Steven J</creatorcontrib><creatorcontrib>Fitzpatrick, Noel</creatorcontrib><creatorcontrib>Pead, Matthew</creatorcontrib><creatorcontrib>Bennett, David</creatorcontrib><creatorcontrib>Innes, John F</creatorcontrib><creatorcontrib>Carter, Stuart D</creatorcontrib><creatorcontrib>Ollier, William E.R</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clements, Dylan N</au><au>Short, Andrea D</au><au>Barnes, Annette</au><au>Kennedy, Lorna J</au><au>Ferguson, John F</au><au>Butterworth, Steven J</au><au>Fitzpatrick, Noel</au><au>Pead, Matthew</au><au>Bennett, David</au><au>Innes, John F</au><au>Carter, Stuart D</au><au>Ollier, William E.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candidate Gene Study of Canine Joint Diseases</atitle><jtitle>The Journal of heredity</jtitle><addtitle>J Hered</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>101</volume><issue>1</issue><spage>54</spage><epage>60</epage><pages>54-60</pages><issn>0022-1503</issn><eissn>1465-7333</eissn><coden>JOHEA8</coden><abstract>Canine osteoarthritis (OA) commonly occurs in association with articular diseases, such as hip dysplasia (HD), elbow dysplasia (ED), or cranial cruciate ligament rupture (CCLR). 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals association canine Dogs Female gene Gene Frequency Genetic disorders Genetic Predisposition to Disease Genomics joint Joint Diseases - genetics Joints Male osteoarthritis Polymorphism, Single Nucleotide |
| title | Candidate Gene Study of Canine Joint Diseases |
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