Relationship between single nucleotide polymorphism-56 of calpain-10 gene and glucose and lipid metabolism in polycystic ovary syndrome patients
To investigate the relationship between single nucleotide polymorphism-56 (SNP-56) in calpain-10 (CAPN-10) gene and polycystic ovary syndrome (PCOS) in Chinese. The genotypes of SNP-56 of CAPN-10 were determined through polymerase chain reaction Tm-shift genotyping method in 638 local women in Shand...
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| Veröffentlicht in: | Chung-hua fu chʿan kʿo tsa chih 2008-02, Vol.43 (2), p.106-109 |
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| container_title | Chung-hua fu chʿan kʿo tsa chih |
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| creator | Diao, Xing-Hua Shi, Yu-Hua Gao, Qin Wang, Lai-Cheng Tang, Rong Chen, Zi-Jiang |
| description | To investigate the relationship between single nucleotide polymorphism-56 (SNP-56) in calpain-10 (CAPN-10) gene and polycystic ovary syndrome (PCOS) in Chinese.
The genotypes of SNP-56 of CAPN-10 were determined through polymerase chain reaction Tm-shift genotyping method in 638 local women in Shandong Province. Among them, 334 were patients with PCOS (PCOS group) and 304 were normal women (control group). The baseline parameters including levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), testosterone (T) and lipid,as well as the body mass index (BMI) and waist/hip ratio (WHR) were measured. Glucose tolerance and insulin releasing before and after loading with 75 g of glucose were also assayed.
(1) The frequencies of two allelotypes or three genotypes did not differ between PCOS women and normal women (P > 0.05). (2) In PCOS group, patients with AA genotype had a significantly higher plasma glucose of 180 minutes OGTT (5.7 +/- 2. 2)mmol/L [P < 0.01 |
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The genotypes of SNP-56 of CAPN-10 were determined through polymerase chain reaction Tm-shift genotyping method in 638 local women in Shandong Province. Among them, 334 were patients with PCOS (PCOS group) and 304 were normal women (control group). The baseline parameters including levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), testosterone (T) and lipid,as well as the body mass index (BMI) and waist/hip ratio (WHR) were measured. Glucose tolerance and insulin releasing before and after loading with 75 g of glucose were also assayed.
(1) The frequencies of two allelotypes or three genotypes did not differ between PCOS women and normal women (P > 0.05). (2) In PCOS group, patients with AA genotype had a significantly higher plasma glucose of 180 minutes OGTT (5.7 +/- 2. 2)mmol/L [P < 0.01</description><identifier>ISSN: 0529-567X</identifier><identifier>PMID: 18683748</identifier><language>chi</language><publisher>China</publisher><subject>Adolescent ; Adult ; Blood Glucose - metabolism ; Calpain - genetics ; Diabetes Mellitus, Type 2 - genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Glucose Tolerance Test ; Humans ; Insulin - blood ; Insulin Resistance ; Lipids - blood ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - genetics ; Polycystic Ovary Syndrome - metabolism ; Polymorphism, Single Nucleotide ; Triglycerides - blood ; Young Adult</subject><ispartof>Chung-hua fu chʿan kʿo tsa chih, 2008-02, Vol.43 (2), p.106-109</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18683748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diao, Xing-Hua</creatorcontrib><creatorcontrib>Shi, Yu-Hua</creatorcontrib><creatorcontrib>Gao, Qin</creatorcontrib><creatorcontrib>Wang, Lai-Cheng</creatorcontrib><creatorcontrib>Tang, Rong</creatorcontrib><creatorcontrib>Chen, Zi-Jiang</creatorcontrib><title>Relationship between single nucleotide polymorphism-56 of calpain-10 gene and glucose and lipid metabolism in polycystic ovary syndrome patients</title><title>Chung-hua fu chʿan kʿo tsa chih</title><addtitle>Zhonghua Fu Chan Ke Za Zhi</addtitle><description>To investigate the relationship between single nucleotide polymorphism-56 (SNP-56) in calpain-10 (CAPN-10) gene and polycystic ovary syndrome (PCOS) in Chinese.
The genotypes of SNP-56 of CAPN-10 were determined through polymerase chain reaction Tm-shift genotyping method in 638 local women in Shandong Province. Among them, 334 were patients with PCOS (PCOS group) and 304 were normal women (control group). The baseline parameters including levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), testosterone (T) and lipid,as well as the body mass index (BMI) and waist/hip ratio (WHR) were measured. Glucose tolerance and insulin releasing before and after loading with 75 g of glucose were also assayed.
(1) The frequencies of two allelotypes or three genotypes did not differ between PCOS women and normal women (P > 0.05). (2) In PCOS group, patients with AA genotype had a significantly higher plasma glucose of 180 minutes OGTT (5.7 +/- 2. 2)mmol/L [P < 0.01</description><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Calpain - genetics</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Lipids - blood</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - genetics</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Triglycerides - blood</subject><subject>Young Adult</subject><issn>0529-567X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1KxDAUhbtQnGGcV5DsXBWapE3TpQz-wYAgCu5Kkt7MBPJnkyp9Cx_Z4oyrcxfnfPdwLop11ZCubFj7sSq2KRlZNZgyTnB3VawwZ5y2NV8XP69gRTbBp6OJSEL-BvAoGX-wgPykLIRsBkAx2NmFMR5NcgsVBY2UsFEYX-IKHcADEn5ABzupkE63NdEMyEEWMtglhoz_w6g5ZaNQ-BLjjNLshzG45cHSAnxO18WlFjbB9qyb4v3h_m33VO5fHp93d_syYtLksgYguhokEZJrqgkWTBMupZK6pVww4IoIDFxqoF1XU604UUQ3TQV6YC2nm-L2xI1j-Jwg5d6ZpMBa4SFMqW8pZYwz1izOm7Nzkg6GPo7GLdX7_xHpL6RacpM</recordid><startdate>200802</startdate><enddate>200802</enddate><creator>Diao, Xing-Hua</creator><creator>Shi, Yu-Hua</creator><creator>Gao, Qin</creator><creator>Wang, Lai-Cheng</creator><creator>Tang, Rong</creator><creator>Chen, Zi-Jiang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200802</creationdate><title>Relationship between single nucleotide polymorphism-56 of calpain-10 gene and glucose and lipid metabolism in polycystic ovary syndrome patients</title><author>Diao, Xing-Hua ; Shi, Yu-Hua ; Gao, Qin ; Wang, Lai-Cheng ; Tang, Rong ; Chen, Zi-Jiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p125t-4ee2f0db2ab8f3f21a6f28bbcbf738a6e8c2a1e8bfe39943fc82c2f550efd6783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Calpain - genetics</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Lipids - blood</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - genetics</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Triglycerides - blood</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Diao, Xing-Hua</creatorcontrib><creatorcontrib>Shi, Yu-Hua</creatorcontrib><creatorcontrib>Gao, Qin</creatorcontrib><creatorcontrib>Wang, Lai-Cheng</creatorcontrib><creatorcontrib>Tang, Rong</creatorcontrib><creatorcontrib>Chen, Zi-Jiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chung-hua fu chʿan kʿo tsa chih</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diao, Xing-Hua</au><au>Shi, Yu-Hua</au><au>Gao, Qin</au><au>Wang, Lai-Cheng</au><au>Tang, Rong</au><au>Chen, Zi-Jiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between single nucleotide polymorphism-56 of calpain-10 gene and glucose and lipid metabolism in polycystic ovary syndrome patients</atitle><jtitle>Chung-hua fu chʿan kʿo tsa chih</jtitle><addtitle>Zhonghua Fu Chan Ke Za Zhi</addtitle><date>2008-02</date><risdate>2008</risdate><volume>43</volume><issue>2</issue><spage>106</spage><epage>109</epage><pages>106-109</pages><issn>0529-567X</issn><abstract>To investigate the relationship between single nucleotide polymorphism-56 (SNP-56) in calpain-10 (CAPN-10) gene and polycystic ovary syndrome (PCOS) in Chinese.
The genotypes of SNP-56 of CAPN-10 were determined through polymerase chain reaction Tm-shift genotyping method in 638 local women in Shandong Province. Among them, 334 were patients with PCOS (PCOS group) and 304 were normal women (control group). The baseline parameters including levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), testosterone (T) and lipid,as well as the body mass index (BMI) and waist/hip ratio (WHR) were measured. Glucose tolerance and insulin releasing before and after loading with 75 g of glucose were also assayed.
(1) The frequencies of two allelotypes or three genotypes did not differ between PCOS women and normal women (P > 0.05). (2) In PCOS group, patients with AA genotype had a significantly higher plasma glucose of 180 minutes OGTT (5.7 +/- 2. 2)mmol/L [P < 0.01</abstract><cop>China</cop><pmid>18683748</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Chung-hua fu chʿan kʿo tsa chih, 2008-02, Vol.43 (2), p.106-109 |
| issn | 0529-567X |
| language | chi |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Blood Glucose - metabolism Calpain - genetics Diabetes Mellitus, Type 2 - genetics Female Gene Frequency Genetic Predisposition to Disease Genotype Glucose Tolerance Test Humans Insulin - blood Insulin Resistance Lipids - blood Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Polymorphism, Single Nucleotide Triglycerides - blood Young Adult |
| title | Relationship between single nucleotide polymorphism-56 of calpain-10 gene and glucose and lipid metabolism in polycystic ovary syndrome patients |
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