Biomedical applications of degradable polyphosphazenes
This article describes the synthesis of biodegradable polyphosphazenes. The rate of degradation can be varied in a controllable manner by the introduction of hydrolysis‐sensitive amino acid ester side groups or by blending of polymers. Biodegradable polyphosphazenes can be used for the preparation o...
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| Veröffentlicht in: | Biotechnology and bioengineering 1996-10, Vol.52 (1), p.102-108 |
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| container_end_page | 108 |
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| container_issue | 1 |
| container_start_page | 102 |
| container_title | Biotechnology and bioengineering |
| container_volume | 52 |
| creator | Schacht, Etienne Vandorpe, Joke Dejardin, Stéphane Lemmouchi, Yahia Seymour, Leonard |
| description | This article describes the synthesis of biodegradable polyphosphazenes. The rate of degradation can be varied in a controllable manner by the introduction of hydrolysis‐sensitive amino acid ester side groups or by blending of polymers. Biodegradable polyphosphazenes can be used for the preparation of drug‐containing implants and this is illustrated for devices containing the cytostatic agent mitomycin C. This article reviews data about the degradation characteristics of poly[(amino acid ester)phosphazene] derivatives that have been discussed previously. Some new data about MMC‐containing poly[(organo)phosphazene] devices are discussed as well. © 1996 John Wiley & Sons, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0290(19961005)52:1<102::AID-BIT10>3.0.CO;2-Q |
| format | Article |
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| ispartof | Biotechnology and bioengineering, 1996-10, Vol.52 (1), p.102-108 |
| issn | 0006-3592 1097-0290 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | biodegradation Biological and medical sciences drug delivery General pharmacology Medical sciences mitomycin C Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments polyphosphazenes |
| title | Biomedical applications of degradable polyphosphazenes |
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