Glutathione-Redox Balance Regulates c-rel-Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy

The glutathione-redox balance, expressed as the ratio of intracellular reduced glutathione (GSH) and oxidized glutathione, plays an important role in regulating cellular immune responses. In the current study, we demonstrate that alteration of glutathione-redox balance in macrophages by GSH donors l...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-03, Vol.184 (6), p.2918-2929
Hauptverfasser:	Alam, Kaiser, Ghousunnissa, Sheikh, Nair, Shiny, Valluri, Vijaya Lakshmi, Mukhopadhyay, Sangita
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cells, Cultured Glutathione - metabolism Glutathione - physiology Glutathione Disulfide - metabolism Glutathione Disulfide - physiology Humans Immunotherapy, Adoptive - methods Interleukin-12 - antagonists & inhibitors Interleukin-12 - biosynthesis Interleukin-12 - metabolism Interleukin-12 - physiology Intracellular Fluid - immunology Intracellular Fluid - metabolism Macrophages - immunology Macrophages - metabolism Mice Oxidation-Reduction Proto-Oncogene Proteins c-rel - metabolism Proto-Oncogene Proteins c-rel - physiology Reactive Oxygen Species - metabolism Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - therapy
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