Effect of beta-cyclodextrin on production of L-phenylacetyl carbinol by immobilized cells of Saccharomyces cerevisiae
The rate and extent of microbial transformation of higher concentrations of benzaldehyde substrate to L-phenylacetyl carbinol (L-PAC) by immobilized cells of Saccharomyces cerevisiae ATCC 834 was markedly stimulated by addition of different concentrations of beta-cyclodextrin (BCD) to the fermentati...
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| Veröffentlicht in: | Biotechnology and bioengineering 1990-07, Vol.36 (3), p.256-262 |
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| container_title | Biotechnology and bioengineering |
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| creator | Mahmoud, W.M. (Zagazig University, Zagazig, Egypt) El-Sayed, A.H.M.M Coughlin, R.W |
| description | The rate and extent of microbial transformation of higher concentrations of benzaldehyde substrate to L-phenylacetyl carbinol (L-PAC) by immobilized cells of Saccharomyces cerevisiae ATCC 834 was markedly stimulated by addition of different concentrations of beta-cyclodextrin (BCD) to the fermentation medium. With 0.5, 1.0, and 1.5% BCD in the fermentation medium and cumulative doses of benzaldehyde of 12 and 14 g/L, significantly higher yields of L-PAC were obtained, about one- to twofold that of the yields of the control experiments. The favorable effects of BCD were evident in spite of its presence in stoichiometric concentrations significantly lower than those of benzaldehyde. The presence of BCD also appeared to stimulate microbial growth slightly. Enhanced cellular activity was reflected by faster D-glucose consumption and faster benzaldehyde utilization in the presence of BCD |
| doi_str_mv | 10.1002/bit.260360307 |
| format | Article |
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(Zagazig University, Zagazig, Egypt)</creatorcontrib><creatorcontrib>El-Sayed, A.H.M.M</creatorcontrib><creatorcontrib>Coughlin, R.W</creatorcontrib><title>Effect of beta-cyclodextrin on production of L-phenylacetyl carbinol by immobilized cells of Saccharomyces cerevisiae</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol. Bioeng</addtitle><description>The rate and extent of microbial transformation of higher concentrations of benzaldehyde substrate to L-phenylacetyl carbinol (L-PAC) by immobilized cells of Saccharomyces cerevisiae ATCC 834 was markedly stimulated by addition of different concentrations of beta-cyclodextrin (BCD) to the fermentation medium. With 0.5, 1.0, and 1.5% BCD in the fermentation medium and cumulative doses of benzaldehyde of 12 and 14 g/L, significantly higher yields of L-PAC were obtained, about one- to twofold that of the yields of the control experiments. The favorable effects of BCD were evident in spite of its presence in stoichiometric concentrations significantly lower than those of benzaldehyde. The presence of BCD also appeared to stimulate microbial growth slightly. Enhanced cellular activity was reflected by faster D-glucose consumption and faster benzaldehyde utilization in the presence of BCD</description><subject>ACIDE ORGANIQUE</subject><subject>ACIDOS ORGANICOS</subject><subject>ALDEHIDOS</subject><subject>ALDEHYDE</subject><subject>beta -cyclodextrin</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>DEXTRINAS</subject><subject>DEXTRINE</subject><subject>FERMENTACION</subject><subject>FERMENTATION</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>IMMOBILISATION</subject><subject>immobilized cells</subject><subject>INMOVILIZACION</subject><subject>L-phenylacetyl carbinol</subject><subject>Methods. Procedures. 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| fulltext | fulltext |
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| ispartof | Biotechnology and bioengineering, 1990-07, Vol.36 (3), p.256-262 |
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| language | eng |
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| subjects | ACIDE ORGANIQUE ACIDOS ORGANICOS ALDEHIDOS ALDEHYDE beta -cyclodextrin Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology DEXTRINAS DEXTRINE FERMENTACION FERMENTATION Fundamental and applied biological sciences. Psychology IMMOBILISATION immobilized cells INMOVILIZACION L-phenylacetyl carbinol Methods. Procedures. Technologies SACCHAROMYCES CEREVISIAE |
| title | Effect of beta-cyclodextrin on production of L-phenylacetyl carbinol by immobilized cells of Saccharomyces cerevisiae |
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