Inhibition of microbial growth and metabolism by excess turbulence
Excess turbulence caused by high‐intensity stirring inhibited microbial growth and metabolism. In stirred tank bioreactors, the growth rate and lysine biosynthesis decreased in Brevibacterium flavum beyond 900 rpm, the growth rate of Trichoderma reesei on wheat straw beyond 150 rpm, and the growth r...
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| Veröffentlicht in: | Biotechnology and bioengineering 1991-08, Vol.38 (5), p.552-556 |
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| creator | Toma, M. K. Ruklisha, M. P. Vanags, J. J. Zeltina, M. O. Lelte, M. P. Galinine, N. I. Viesturs, U. E. Tengerdy, R. P. |
| description | Excess turbulence caused by high‐intensity stirring inhibited microbial growth and metabolism. In stirred tank bioreactors, the growth rate and lysine biosynthesis decreased in Brevibacterium flavum beyond 900 rpm, the growth rate of Trichoderma reesei on wheat straw beyond 150 rpm, and the growth rate of Saccharomyces cerevisae beyond 800 rpm. The term turbohypobiosis was introduced to describe this inhibition. Turbohypobiosis was characterized by a stress factor Fstr expressing the interaction of medium flow with microbial cells in local turbulent zones, dependent on the energy distribution of the stirring regime. Lysine synthesis was inhibited at significantly lower Fstr values than the growth of B. flavum. The main reason for the inhibition was shear effects causing decreased adenosine triphosphate (ATP) generation, lower O2 uptake, and lower specific growth rate of bacteria. |
| doi_str_mv | 10.1002/bit.260380514 |
| format | Article |
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K. ; Ruklisha, M. P. ; Vanags, J. J. ; Zeltina, M. O. ; Lelte, M. P. ; Galinine, N. I. ; Viesturs, U. E. ; Tengerdy, R. P.</creator><creatorcontrib>Toma, M. K. ; Ruklisha, M. P. ; Vanags, J. J. ; Zeltina, M. O. ; Lelte, M. P. ; Galinine, N. I. ; Viesturs, U. E. ; Tengerdy, R. P.</creatorcontrib><description>Excess turbulence caused by high‐intensity stirring inhibited microbial growth and metabolism. In stirred tank bioreactors, the growth rate and lysine biosynthesis decreased in Brevibacterium flavum beyond 900 rpm, the growth rate of Trichoderma reesei on wheat straw beyond 150 rpm, and the growth rate of Saccharomyces cerevisae beyond 800 rpm. The term turbohypobiosis was introduced to describe this inhibition. Turbohypobiosis was characterized by a stress factor Fstr expressing the interaction of medium flow with microbial cells in local turbulent zones, dependent on the energy distribution of the stirring regime. Lysine synthesis was inhibited at significantly lower Fstr values than the growth of B. flavum. The main reason for the inhibition was shear effects causing decreased adenosine triphosphate (ATP) generation, lower O2 uptake, and lower specific growth rate of bacteria.</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/bit.260380514</identifier><identifier>PMID: 18604814</identifier><identifier>CODEN: BIBIAU</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; bioreactors ; Biotechnology ; Brevibacterium flavum ; Fundamental and applied biological sciences. Psychology ; lysine ; lysine fermentation ; Methods. Procedures. Technologies ; Microbial engineering. Fermentation and microbial culture technology ; Saccharomyces cerevisiae ; shear effects ; stirring ; Trichoderma reesei ; turbulence</subject><ispartof>Biotechnology and bioengineering, 1991-08, Vol.38 (5), p.552-556</ispartof><rights>Copyright © 1991 John Wiley & Sons, Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5774-6d0fb8504e268962498e946d90349410d02e15efb310cee427961b491956caba3</citedby><cites>FETCH-LOGICAL-c5774-6d0fb8504e268962498e946d90349410d02e15efb310cee427961b491956caba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbit.260380514$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbit.260380514$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5116374$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18604814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toma, M. K.</creatorcontrib><creatorcontrib>Ruklisha, M. P.</creatorcontrib><creatorcontrib>Vanags, J. J.</creatorcontrib><creatorcontrib>Zeltina, M. O.</creatorcontrib><creatorcontrib>Lelte, M. P.</creatorcontrib><creatorcontrib>Galinine, N. I.</creatorcontrib><creatorcontrib>Viesturs, U. E.</creatorcontrib><creatorcontrib>Tengerdy, R. P.</creatorcontrib><title>Inhibition of microbial growth and metabolism by excess turbulence</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol. Bioeng</addtitle><description>Excess turbulence caused by high‐intensity stirring inhibited microbial growth and metabolism. In stirred tank bioreactors, the growth rate and lysine biosynthesis decreased in Brevibacterium flavum beyond 900 rpm, the growth rate of Trichoderma reesei on wheat straw beyond 150 rpm, and the growth rate of Saccharomyces cerevisae beyond 800 rpm. The term turbohypobiosis was introduced to describe this inhibition. Turbohypobiosis was characterized by a stress factor Fstr expressing the interaction of medium flow with microbial cells in local turbulent zones, dependent on the energy distribution of the stirring regime. Lysine synthesis was inhibited at significantly lower Fstr values than the growth of B. flavum. The main reason for the inhibition was shear effects causing decreased adenosine triphosphate (ATP) generation, lower O2 uptake, and lower specific growth rate of bacteria.</description><subject>Biological and medical sciences</subject><subject>bioreactors</subject><subject>Biotechnology</subject><subject>Brevibacterium flavum</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>lysine</subject><subject>lysine fermentation</subject><subject>Methods. Procedures. Technologies</subject><subject>Microbial engineering. Fermentation and microbial culture technology</subject><subject>Saccharomyces cerevisiae</subject><subject>shear effects</subject><subject>stirring</subject><subject>Trichoderma reesei</subject><subject>turbulence</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNp90EtP3DAUBWALFcFAu2SLsqjKKnD9iB0vmWlLR0J0Q9XuLNu5AUMe1E4E8-8bNNGUFSvL0ufjew8hJxTOKQC7cGE4ZxJ4CQUVe2RBQascmIYPZAEAMueFZofkKKWH6apKKQ_IIS0liJKKBVmuu_swZYS-y_o6a4OPvQu2ye5i_zzcZ7arshYH6_ompDZzmwxfPKaUDWN0Y4Odx49kv7ZNwk_zeUx-ff92u_qRX_-8Wq8ur3NfKCVyWUHtygIEMllqyYQuUQtZaeBCCwoVMKQF1o5T8IiCKS2pE5rqQnrrLD8mZ9vcp9j_HTENpg3JY9PYDvsxGcW5lFRwmOSXdyWVoBRVaoL5Fk5bpxSxNk8xtDZuDAXzWq-ZqjG7eid_OgePrsXqv577nMDnGdjkbVNH2_mQdq6gVHL1ytSWPYcGN-9_apbr27cTzBOHNODL7qWNj0Yqrgrz--bKfNUrtvzDhQH-D4V1n7Q</recordid><startdate>19910820</startdate><enddate>19910820</enddate><creator>Toma, M. K.</creator><creator>Ruklisha, M. 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P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of microbial growth and metabolism by excess turbulence</atitle><jtitle>Biotechnology and bioengineering</jtitle><addtitle>Biotechnol. Bioeng</addtitle><date>1991-08-20</date><risdate>1991</risdate><volume>38</volume><issue>5</issue><spage>552</spage><epage>556</epage><pages>552-556</pages><issn>0006-3592</issn><eissn>1097-0290</eissn><coden>BIBIAU</coden><abstract>Excess turbulence caused by high‐intensity stirring inhibited microbial growth and metabolism. In stirred tank bioreactors, the growth rate and lysine biosynthesis decreased in Brevibacterium flavum beyond 900 rpm, the growth rate of Trichoderma reesei on wheat straw beyond 150 rpm, and the growth rate of Saccharomyces cerevisae beyond 800 rpm. The term turbohypobiosis was introduced to describe this inhibition. 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| subjects | Biological and medical sciences bioreactors Biotechnology Brevibacterium flavum Fundamental and applied biological sciences. Psychology lysine lysine fermentation Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology Saccharomyces cerevisiae shear effects stirring Trichoderma reesei turbulence |
| title | Inhibition of microbial growth and metabolism by excess turbulence |
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