Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors

Tumor cells that are grown in three-dimensional (3D) cell culture exhibit relative resistance to cytotoxic drugs compared with their response in conventional two-dimensional (2D) culture. We studied the effects of targeted agents and doxorubicin on 2D and 3D cultures of human breast cell lines that...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2010-03, Vol.332 (3), p.821-828
Hauptverfasser:	Li, Quanwen, Chow, Albert B, Mattingly, Raymond R
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Antineoplastic Agents - pharmacology Benzamides - pharmacology Breast Neoplasms Butadienes - pharmacology Cell Culture Techniques Cell Line Cell Line, Transformed Cell Line, Tumor Cell Proliferation - drug effects Doxorubicin - pharmacology Drug Resistance, Neoplasm Female Genes, ras Humans Hyperplasia Mammary Glands, Human - cytology Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Nitriles - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors
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