Caveolin-1 Regulating the Invasion and Expression of Matrix Metalloproteinase (MMPs) in Pancreatic Carcinoma Cells

The gelatinases B (MMP9) and A (MMP2) are two members of the matrix metalloproteinase (MMPs) family that are expressed in human cancer, and play a critical role in tumor cell invasion and metastasis. Caveolin-1 (Cav1) has recently been identified as a tumor metastasis modifier gene. However, the eff...

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Veröffentlicht in:	The Journal of surgical research 2010-03, Vol.159 (1), p.443-450
Hauptverfasser:	Han, Fei, Ph.D, Zhu, Hong-Guang, Ph.D., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma - enzymology Caveolin 1 - genetics Caveolin 1 - metabolism caveolin-1 Cell Line, Tumor Chromones Epithelial Cells - enzymology Extracellular Signal-Regulated MAP Kinases - metabolism Flavonoids Gastroenterology. Liver. Pancreas. Abdomen Gene Knockdown Techniques General aspects Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas MAP Kinase Signaling System matrix metalloproteinase Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 2 - secretion Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase 9 - secretion Medical sciences Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Morpholines Neoplasm Invasiveness pancreatic carcinoma Pancreatic Ducts - enzymology Pancreatic Neoplasms - enzymology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism RNA Interference RNA, Messenger - metabolism RNA, Small Interfering - metabolism Surgery Tumors
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