Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient
Abstract Objectives Components released from resin-based dental materials are important factors in the assessment of the biocompatibility of these materials. The study was performed to investigate the elution of substances from unpolymerized and polymerized composites (Tetric® = TET; Arabesk® = ARA)...
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| Veröffentlicht in: | Dental materials 2010-01, Vol.26 (1), p.91-99 |
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| creator | Durner, Jürgen Spahl, Werner Zaspel, Johannes Schweikl, Helmut Hickel, Reinhard Reichl, Franx-Xaver |
| description | Abstract Objectives Components released from resin-based dental materials are important factors in the assessment of the biocompatibility of these materials. The study was performed to investigate the elution of substances from unpolymerized and polymerized composites (Tetric® = TET; Arabesk® = ARA), ormoceres (Admira® = ADM; Definite® = DEF) and the compomere (Hytac® = HYT). Methods Specimens were polymerized and immersed in either water or methanol. Besides the unpolymerized specimens were dissolved in methanol. Eluted substances were detected by gas chromatography/mass spectroscopy. The Nernst partition coefficient (DC) of 64 substances, eluted from various resin-based dental materials was determined. Results Only in methanolic and aqueous eluates from unpolymerized and polymerized specimens of DEF and ADM, the comonomere 1,2/1,3-glycerol dimethacrylate was measured. Triethylene glycol dimethacrylate was eluted into the aqueous and methanolic phase from polymerized specimens from TET and ARA. 2-Hydroxyethyl methacrylate was eluted into the methanolic phase from polymerized specimen from TET and HYT. Residuals of monomer synthesis like triphenyl stibane were found in unpolymerized specimens of TET and ARA. Camphorquinone was eluted into the methanolic eluate from polymerized and unpolymerized specimens from all tested dental materials. Highest DC of 20.8 was found for 1/2-cyclohexene methacrylate. DC of urethane dimethacrylate and bisphenol-A-glycidyldimethacrylate varies from different manufacturers. Significance Impurities from manufacturing process were found in some resin-based materials. Various well-known substances causing allergic reactions were found in aqueous or methanolic elutes. Patients, dental and manufacturing personnel are exposed to these substances. |
| doi_str_mv | 10.1016/j.dental.2009.08.014 |
| format | Article |
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The study was performed to investigate the elution of substances from unpolymerized and polymerized composites (Tetric® = TET; Arabesk® = ARA), ormoceres (Admira® = ADM; Definite® = DEF) and the compomere (Hytac® = HYT). Methods Specimens were polymerized and immersed in either water or methanol. Besides the unpolymerized specimens were dissolved in methanol. Eluted substances were detected by gas chromatography/mass spectroscopy. The Nernst partition coefficient (DC) of 64 substances, eluted from various resin-based dental materials was determined. Results Only in methanolic and aqueous eluates from unpolymerized and polymerized specimens of DEF and ADM, the comonomere 1,2/1,3-glycerol dimethacrylate was measured. Triethylene glycol dimethacrylate was eluted into the aqueous and methanolic phase from polymerized specimens from TET and ARA. 2-Hydroxyethyl methacrylate was eluted into the methanolic phase from polymerized specimen from TET and HYT. Residuals of monomer synthesis like triphenyl stibane were found in unpolymerized specimens of TET and ARA. Camphorquinone was eluted into the methanolic eluate from polymerized and unpolymerized specimens from all tested dental materials. Highest DC of 20.8 was found for 1/2-cyclohexene methacrylate. DC of urethane dimethacrylate and bisphenol-A-glycidyldimethacrylate varies from different manufacturers. Significance Impurities from manufacturing process were found in some resin-based materials. Various well-known substances causing allergic reactions were found in aqueous or methanolic elutes. Patients, dental and manufacturing personnel are exposed to these substances.</description><identifier>ISSN: 0109-5641</identifier><identifier>EISSN: 1879-0097</identifier><identifier>DOI: 10.1016/j.dental.2009.08.014</identifier><identifier>PMID: 19781758</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Allergic reaction ; Aqueous eluate ; Biocompatible Materials - chemistry ; Bisphenol A-Glycidyl Methacrylate - chemistry ; Ceramics - chemistry ; Compomers - chemistry ; Composite Resins - chemistry ; Cyclohexenes - chemistry ; Dental Materials - chemistry ; Dentistry ; Eluted substances ; Gas Chromatography-Mass Spectrometry ; Glass Ionomer Cements - chemistry ; Glycerides - chemistry ; HEMA ; Humans ; Materials Testing ; Methacrylates - chemistry ; Methanol - chemistry ; Methanolic eluate ; Models, Chemical ; Nernst partition coefficient ; Organically Modified Ceramics ; Polyethylene Glycols - chemistry ; Polymerized specimen ; Polymers - chemistry ; Polymethacrylic Acids - chemistry ; Polyurethanes - chemistry ; Silanes - chemistry ; Siloxanes - chemistry ; Solvents - chemistry ; Stilbenes - chemistry ; TEGDMA ; Terpenes - chemistry ; Unpolymerized specimen ; Water - chemistry</subject><ispartof>Dental materials, 2010-01, Vol.26 (1), p.91-99</ispartof><rights>Academy of Dental Materials</rights><rights>2009 Academy of Dental Materials</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-fb58d7d79913b5d541121dbf36e77029719adf43825867895b0a779160e9317b3</citedby><cites>FETCH-LOGICAL-c416t-fb58d7d79913b5d541121dbf36e77029719adf43825867895b0a779160e9317b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0109564109003030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19781758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durner, Jürgen</creatorcontrib><creatorcontrib>Spahl, Werner</creatorcontrib><creatorcontrib>Zaspel, Johannes</creatorcontrib><creatorcontrib>Schweikl, Helmut</creatorcontrib><creatorcontrib>Hickel, Reinhard</creatorcontrib><creatorcontrib>Reichl, Franx-Xaver</creatorcontrib><title>Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient</title><title>Dental materials</title><addtitle>Dent Mater</addtitle><description>Abstract Objectives Components released from resin-based dental materials are important factors in the assessment of the biocompatibility of these materials. The study was performed to investigate the elution of substances from unpolymerized and polymerized composites (Tetric® = TET; Arabesk® = ARA), ormoceres (Admira® = ADM; Definite® = DEF) and the compomere (Hytac® = HYT). Methods Specimens were polymerized and immersed in either water or methanol. Besides the unpolymerized specimens were dissolved in methanol. Eluted substances were detected by gas chromatography/mass spectroscopy. The Nernst partition coefficient (DC) of 64 substances, eluted from various resin-based dental materials was determined. Results Only in methanolic and aqueous eluates from unpolymerized and polymerized specimens of DEF and ADM, the comonomere 1,2/1,3-glycerol dimethacrylate was measured. Triethylene glycol dimethacrylate was eluted into the aqueous and methanolic phase from polymerized specimens from TET and ARA. 2-Hydroxyethyl methacrylate was eluted into the methanolic phase from polymerized specimen from TET and HYT. Residuals of monomer synthesis like triphenyl stibane were found in unpolymerized specimens of TET and ARA. Camphorquinone was eluted into the methanolic eluate from polymerized and unpolymerized specimens from all tested dental materials. Highest DC of 20.8 was found for 1/2-cyclohexene methacrylate. DC of urethane dimethacrylate and bisphenol-A-glycidyldimethacrylate varies from different manufacturers. Significance Impurities from manufacturing process were found in some resin-based materials. Various well-known substances causing allergic reactions were found in aqueous or methanolic elutes. Patients, dental and manufacturing personnel are exposed to these substances.</description><subject>Advanced Basic Science</subject><subject>Allergic reaction</subject><subject>Aqueous eluate</subject><subject>Biocompatible Materials - chemistry</subject><subject>Bisphenol A-Glycidyl Methacrylate - chemistry</subject><subject>Ceramics - chemistry</subject><subject>Compomers - chemistry</subject><subject>Composite Resins - chemistry</subject><subject>Cyclohexenes - chemistry</subject><subject>Dental Materials - chemistry</subject><subject>Dentistry</subject><subject>Eluted substances</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Glass Ionomer Cements - chemistry</subject><subject>Glycerides - chemistry</subject><subject>HEMA</subject><subject>Humans</subject><subject>Materials Testing</subject><subject>Methacrylates - chemistry</subject><subject>Methanol - chemistry</subject><subject>Methanolic eluate</subject><subject>Models, Chemical</subject><subject>Nernst partition coefficient</subject><subject>Organically Modified Ceramics</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymerized specimen</subject><subject>Polymers - chemistry</subject><subject>Polymethacrylic Acids - chemistry</subject><subject>Polyurethanes - chemistry</subject><subject>Silanes - chemistry</subject><subject>Siloxanes - chemistry</subject><subject>Solvents - chemistry</subject><subject>Stilbenes - chemistry</subject><subject>TEGDMA</subject><subject>Terpenes - chemistry</subject><subject>Unpolymerized specimen</subject><subject>Water - chemistry</subject><issn>0109-5641</issn><issn>1879-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1URLeFf1Ch3HpKmMmX4wsSqgpFquAAnC3Hnghvk3ixnarLr8chK4G4IB8szzwzr-cdxq4QCgRs3-wLQ3NUY1ECiAK6ArB-xnbYcZGnCD9jO0AQedPWeM4uQtgDQF0KfMHOUfAOedPt2NPtuEQyWVj6ENWsKWSDd1O2zAc3Hify9mfKqtlkf7835cxTiM6raB8pm1RMSTWG33D8TtZnn8jPIWYH5aON1s2ZdjQMVttU_pI9HxJNr073Jfv2_vbrzV1-__nDx5t397musY350Ded4YYLgVXfmKZGLNH0Q9US51AKjkKZoa66sula3ommB8W5wBZIVMj76pJdb30P3v1Y0oflZIOmcVQzuSVIXlVt03JeJ7LeSO1dCJ4GefB2Uv4oEeRqudzLbXC5Wi6hk8nyVPb6JLD0E5k_RSePE_B2AyiN-WjJy7A6oMlYTzpK4-z_FP5toEc7W63GBzpS2LvFz8lCiTKUEuSXde3r1kEAVOv5BTVhqzg</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Durner, Jürgen</creator><creator>Spahl, Werner</creator><creator>Zaspel, Johannes</creator><creator>Schweikl, Helmut</creator><creator>Hickel, Reinhard</creator><creator>Reichl, Franx-Xaver</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient</title><author>Durner, Jürgen ; Spahl, Werner ; Zaspel, Johannes ; Schweikl, Helmut ; Hickel, Reinhard ; Reichl, Franx-Xaver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-fb58d7d79913b5d541121dbf36e77029719adf43825867895b0a779160e9317b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Advanced Basic Science</topic><topic>Allergic reaction</topic><topic>Aqueous eluate</topic><topic>Biocompatible Materials - chemistry</topic><topic>Bisphenol A-Glycidyl Methacrylate - chemistry</topic><topic>Ceramics - chemistry</topic><topic>Compomers - chemistry</topic><topic>Composite Resins - chemistry</topic><topic>Cyclohexenes - chemistry</topic><topic>Dental Materials - chemistry</topic><topic>Dentistry</topic><topic>Eluted substances</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Glass Ionomer Cements - chemistry</topic><topic>Glycerides - chemistry</topic><topic>HEMA</topic><topic>Humans</topic><topic>Materials Testing</topic><topic>Methacrylates - chemistry</topic><topic>Methanol - chemistry</topic><topic>Methanolic eluate</topic><topic>Models, Chemical</topic><topic>Nernst partition coefficient</topic><topic>Organically Modified Ceramics</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymerized specimen</topic><topic>Polymers - chemistry</topic><topic>Polymethacrylic Acids - chemistry</topic><topic>Polyurethanes - chemistry</topic><topic>Silanes - chemistry</topic><topic>Siloxanes - chemistry</topic><topic>Solvents - chemistry</topic><topic>Stilbenes - chemistry</topic><topic>TEGDMA</topic><topic>Terpenes - chemistry</topic><topic>Unpolymerized specimen</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durner, Jürgen</creatorcontrib><creatorcontrib>Spahl, Werner</creatorcontrib><creatorcontrib>Zaspel, Johannes</creatorcontrib><creatorcontrib>Schweikl, Helmut</creatorcontrib><creatorcontrib>Hickel, Reinhard</creatorcontrib><creatorcontrib>Reichl, Franx-Xaver</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dental materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durner, Jürgen</au><au>Spahl, Werner</au><au>Zaspel, Johannes</au><au>Schweikl, Helmut</au><au>Hickel, Reinhard</au><au>Reichl, Franx-Xaver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient</atitle><jtitle>Dental materials</jtitle><addtitle>Dent Mater</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>26</volume><issue>1</issue><spage>91</spage><epage>99</epage><pages>91-99</pages><issn>0109-5641</issn><eissn>1879-0097</eissn><abstract>Abstract Objectives Components released from resin-based dental materials are important factors in the assessment of the biocompatibility of these materials. The study was performed to investigate the elution of substances from unpolymerized and polymerized composites (Tetric® = TET; Arabesk® = ARA), ormoceres (Admira® = ADM; Definite® = DEF) and the compomere (Hytac® = HYT). Methods Specimens were polymerized and immersed in either water or methanol. Besides the unpolymerized specimens were dissolved in methanol. Eluted substances were detected by gas chromatography/mass spectroscopy. The Nernst partition coefficient (DC) of 64 substances, eluted from various resin-based dental materials was determined. Results Only in methanolic and aqueous eluates from unpolymerized and polymerized specimens of DEF and ADM, the comonomere 1,2/1,3-glycerol dimethacrylate was measured. Triethylene glycol dimethacrylate was eluted into the aqueous and methanolic phase from polymerized specimens from TET and ARA. 2-Hydroxyethyl methacrylate was eluted into the methanolic phase from polymerized specimen from TET and HYT. Residuals of monomer synthesis like triphenyl stibane were found in unpolymerized specimens of TET and ARA. Camphorquinone was eluted into the methanolic eluate from polymerized and unpolymerized specimens from all tested dental materials. Highest DC of 20.8 was found for 1/2-cyclohexene methacrylate. DC of urethane dimethacrylate and bisphenol-A-glycidyldimethacrylate varies from different manufacturers. Significance Impurities from manufacturing process were found in some resin-based materials. Various well-known substances causing allergic reactions were found in aqueous or methanolic elutes. Patients, dental and manufacturing personnel are exposed to these substances.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19781758</pmid><doi>10.1016/j.dental.2009.08.014</doi><tpages>9</tpages></addata></record> |
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| subjects | Advanced Basic Science Allergic reaction Aqueous eluate Biocompatible Materials - chemistry Bisphenol A-Glycidyl Methacrylate - chemistry Ceramics - chemistry Compomers - chemistry Composite Resins - chemistry Cyclohexenes - chemistry Dental Materials - chemistry Dentistry Eluted substances Gas Chromatography-Mass Spectrometry Glass Ionomer Cements - chemistry Glycerides - chemistry HEMA Humans Materials Testing Methacrylates - chemistry Methanol - chemistry Methanolic eluate Models, Chemical Nernst partition coefficient Organically Modified Ceramics Polyethylene Glycols - chemistry Polymerized specimen Polymers - chemistry Polymethacrylic Acids - chemistry Polyurethanes - chemistry Silanes - chemistry Siloxanes - chemistry Solvents - chemistry Stilbenes - chemistry TEGDMA Terpenes - chemistry Unpolymerized specimen Water - chemistry |
| title | Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient |
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