Effect of oxotremorine on resting membrane potential and cell volume in skeletal muscle fibers in rats after in vivo blockade of NO-synthase
Denervation of rat phrenic muscle or block of NO-synthase in vivo increased the cross-section area of muscle fibers and decreased membrane resting potential. Oxotremorine prevented the development of denervation-induced or denervation-like (i.e. induced by NO-synthase blockade) membrane depolarizati...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2003-02, Vol.135 (2), p.120-122 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Khairova, R A Malomuzh, A I Naumenko, N V Urazaev, A Kh |
| description | Denervation of rat phrenic muscle or block of NO-synthase in vivo increased the cross-section area of muscle fibers and decreased membrane resting potential. Oxotremorine prevented the development of denervation-induced or denervation-like (i.e. induced by NO-synthase blockade) membrane depolarization and increase of the cross-sectional area of muscle fibers. Pirenzepine abolished the effects of oxotremorine. It was concluded that non-quantal acetylcholine can be involved in the regulation of skeletal muscle fiber volume via activation of M1 muscarinic receptors followed by NO synthesis. |
| doi_str_mv | 10.1023/A:1023899210383 |
| format | Article |
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Oxotremorine prevented the development of denervation-induced or denervation-like (i.e. induced by NO-synthase blockade) membrane depolarization and increase of the cross-sectional area of muscle fibers. Pirenzepine abolished the effects of oxotremorine. 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| subjects | Acetylcholine - metabolism Animals Cell Size In Vitro Techniques Membrane Potentials - drug effects Membrane Potentials - physiology Muscarinic Agonists - pharmacology Muscarinic Antagonists - pharmacology Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Oxotremorine - pharmacology Pirenzepine - pharmacology Rats |
| title | Effect of oxotremorine on resting membrane potential and cell volume in skeletal muscle fibers in rats after in vivo blockade of NO-synthase |
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