Mcl-1; the molecular regulation of protein function

Apoptosis, an essential and basic biological phenomenon, is regulated in a complex manner by a multitude of factors. Myeloid cell leukemia 1 (Mcl-1), an anti-apoptotic member of the B-cell lymphoma 2 (Bcl-2) family of apoptosis-regulating proteins, exemplifies a number of the mechanisms by which a p...

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Veröffentlicht in:	FEBS letters 2010-07, Vol.584 (14), p.2981-2989
Hauptverfasser:	Thomas, Luke W., Lam, Connie, Edwards, Steven W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics B-cell lymphoma 2 B-Lymphocytes - metabolism BAK BAX BCL-2 Bcl-2 homologous antagonist killer Bcl-2 homology Bcl-2 like protein X Bcl-2 related protein A1 Bcl-2-associated protein X BCL-XL beta transducin-containing protein BFL-1/A1 BH3 interacting domain death agonist BID C-Jun N-terminal kinase cAMP response element cAMP response element binding protein CDK-1 checkpoint 1 protein CHK-1 CHX CRE CREB cyclin dependent kinase 1 cycloheximide Dimerization ERK extracellular regulated protein kinase GM-CSF granulocyte–macrophage colony-stimulating factor granzyme B GrB HIF-1α Humans hypoxia-inducible factor 1α interleukin JNK Leukemia - genetics Leukemia - metabolism Leukemia, Myeloid - genetics Lymphoma, B-Cell - genetics MCL-1 MCL-1 ubiquitin ligase micro inhibiting RNA 29b Mir-29b MULE Myeloid cell leukemia 1 Myeloid Cells - metabolism Myeloid Progenitor Cells - metabolism NF-κB nuclear factor kappa B p53 upregulated modulator of apoptosis PCNA peptidyl-prolyl cis-trans isomerase NIMA interacting protein 1 PEST Phosphorylation Pin-1 Post-translational modification proliferating cell nuclear antigen proline/glutamic acid/serine/threonine Protein Processing, Post-Translational Protein Structure, Tertiary - genetics Proteins - genetics Proteins - metabolism PUMA signal transducers and activators of transcription SRE STAT STAT response element vascular endothelial growth factor VEGF β-TrCP
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