Determinants of Quality of Life in Nursing Home Residents with Dementia
Aims: The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. Methods: This cross-sectional observational study included 288...
Gespeichert in:
| Veröffentlicht in: | Dementia and geriatric cognitive disorders 2010-04, Vol.29 (3), p.189-197 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 197 |
|---|---|
| container_issue | 3 |
| container_start_page | 189 |
| container_title | Dementia and geriatric cognitive disorders |
| container_volume | 29 |
| creator | Wetzels, R.B. Zuidema, S.U. de Jonghe, J.F.M. Verhey, F.R.J. Koopmans, R.T.C.M. |
| description | Aims: The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. Methods: This cross-sectional observational study included 288 individuals with dementia who reside in 14 special care units in 9 nursing homes. The following measures were used: the Qualidem scale to assess QoL, the Neuropsychiatric Inventory-Nursing Home version, the Global Deterioration Scale (GDS), the Severe Impairment Battery-short version, an Activities of Daily Living scale and PDU. Associations between QoL and NPS were examined using multivariate linear regression models with corrections for potential covariates. Results: The average age of the residents was 84 years (SD = ±7). Agitation, depression, psychosis, psychomotor agitation and psychotropic drugs were independently associated with poor QoL. In patients with mild to moderately severe dementia (GDS 4–6), NPS, PDU and cognitive impairment explained almost half of the variance in QoL scores. Agitation and depression were particularly strong predictors of poor QoL. In patients with severe dementia (GDS 7), agitation, depression, psychosis and cognitive impairment were associated with poor QoL. Conclusions: NPS, cognition and PDU independently impair QoL for patients in both the moderate and advanced stages of dementia. These results challenge existing pharmacological intervention strategies and highlight the need for psychosocial interventions in the treatment of NPS. |
| doi_str_mv | 10.1159/000280437 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_733650426</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2012983151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c364t-26cb5b554f7ec8ef836ae55ccaf76ac94b384cf2a90c6e124b85631a802e9d173</originalsourceid><addsrcrecordid>eNqF0UtLw0AQAOBFFFurB-8iwYt4iO47u0dptRWKoug5bLaTurVJdDdB-u9NTa3gxdPMwDcDM4PQMcGXhAh9hTGmCnOW7KA-4ZTEWlG--53jWGGseugghEXLEiH1PupRTIlIBO6j8Qhq8IUrTVmHqMqjx8YsXb1ap1OXQ-TK6L7xwZXzaFIVED1BcDNY409Xv0YjKNrCmUO0l5tlgKNNHKCX25vn4SSePozvhtfT2DLJ65hKm4lMCJ4nYBXkikkDQlhr8kQaq3nGFLc5NRpbCYTyTAnJiFGYgp6RhA3QeTf33VcfDYQ6LVywsFyaEqompAnnQkml-f-SMSkwp7KVZ3_komp82a6RUkYFZorpFl10yPoqBA95-u5dYfwqJThdfyHdfqG1p5uBTVbAbCt_zt6Ckw68GT8H_wu6_i8enoir</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>232503839</pqid></control><display><type>article</type><title>Determinants of Quality of Life in Nursing Home Residents with Dementia</title><source>Karger Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Wetzels, R.B. ; Zuidema, S.U. ; de Jonghe, J.F.M. ; Verhey, F.R.J. ; Koopmans, R.T.C.M.</creator><creatorcontrib>Wetzels, R.B. ; Zuidema, S.U. ; de Jonghe, J.F.M. ; Verhey, F.R.J. ; Koopmans, R.T.C.M.</creatorcontrib><description>Aims: The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. Methods: This cross-sectional observational study included 288 individuals with dementia who reside in 14 special care units in 9 nursing homes. The following measures were used: the Qualidem scale to assess QoL, the Neuropsychiatric Inventory-Nursing Home version, the Global Deterioration Scale (GDS), the Severe Impairment Battery-short version, an Activities of Daily Living scale and PDU. Associations between QoL and NPS were examined using multivariate linear regression models with corrections for potential covariates. Results: The average age of the residents was 84 years (SD = ±7). Agitation, depression, psychosis, psychomotor agitation and psychotropic drugs were independently associated with poor QoL. In patients with mild to moderately severe dementia (GDS 4–6), NPS, PDU and cognitive impairment explained almost half of the variance in QoL scores. Agitation and depression were particularly strong predictors of poor QoL. In patients with severe dementia (GDS 7), agitation, depression, psychosis and cognitive impairment were associated with poor QoL. Conclusions: NPS, cognition and PDU independently impair QoL for patients in both the moderate and advanced stages of dementia. These results challenge existing pharmacological intervention strategies and highlight the need for psychosocial interventions in the treatment of NPS.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000280437</identifier><identifier>PMID: 20215750</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Activities of Daily Living ; Age Factors ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Data Interpretation, Statistical ; Dementia ; Dementia - psychology ; Drug Utilization ; Female ; Humans ; Length of Stay ; Male ; Marital Status ; Middle Aged ; Neuropsychological Tests ; Nursing Homes ; Original Research Article ; Psychiatric Status Rating Scales ; Psychomotor Agitation - complications ; Psychomotor Agitation - psychology ; Psychotropic Drugs - therapeutic use ; Quality of Life ; Regression Analysis ; Sex Factors</subject><ispartof>Dementia and geriatric cognitive disorders, 2010-04, Vol.29 (3), p.189-197</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-26cb5b554f7ec8ef836ae55ccaf76ac94b384cf2a90c6e124b85631a802e9d173</citedby><cites>FETCH-LOGICAL-c364t-26cb5b554f7ec8ef836ae55ccaf76ac94b384cf2a90c6e124b85631a802e9d173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20215750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wetzels, R.B.</creatorcontrib><creatorcontrib>Zuidema, S.U.</creatorcontrib><creatorcontrib>de Jonghe, J.F.M.</creatorcontrib><creatorcontrib>Verhey, F.R.J.</creatorcontrib><creatorcontrib>Koopmans, R.T.C.M.</creatorcontrib><title>Determinants of Quality of Life in Nursing Home Residents with Dementia</title><title>Dementia and geriatric cognitive disorders</title><addtitle>Dement Geriatr Cogn Disord</addtitle><description>Aims: The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. Methods: This cross-sectional observational study included 288 individuals with dementia who reside in 14 special care units in 9 nursing homes. The following measures were used: the Qualidem scale to assess QoL, the Neuropsychiatric Inventory-Nursing Home version, the Global Deterioration Scale (GDS), the Severe Impairment Battery-short version, an Activities of Daily Living scale and PDU. Associations between QoL and NPS were examined using multivariate linear regression models with corrections for potential covariates. Results: The average age of the residents was 84 years (SD = ±7). Agitation, depression, psychosis, psychomotor agitation and psychotropic drugs were independently associated with poor QoL. In patients with mild to moderately severe dementia (GDS 4–6), NPS, PDU and cognitive impairment explained almost half of the variance in QoL scores. Agitation and depression were particularly strong predictors of poor QoL. In patients with severe dementia (GDS 7), agitation, depression, psychosis and cognitive impairment were associated with poor QoL. Conclusions: NPS, cognition and PDU independently impair QoL for patients in both the moderate and advanced stages of dementia. These results challenge existing pharmacological intervention strategies and highlight the need for psychosocial interventions in the treatment of NPS.</description><subject>Activities of Daily Living</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cross-Sectional Studies</subject><subject>Data Interpretation, Statistical</subject><subject>Dementia</subject><subject>Dementia - psychology</subject><subject>Drug Utilization</subject><subject>Female</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Marital Status</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Nursing Homes</subject><subject>Original Research Article</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychomotor Agitation - complications</subject><subject>Psychomotor Agitation - psychology</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>Quality of Life</subject><subject>Regression Analysis</subject><subject>Sex Factors</subject><issn>1420-8008</issn><issn>1421-9824</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0UtLw0AQAOBFFFurB-8iwYt4iO47u0dptRWKoug5bLaTurVJdDdB-u9NTa3gxdPMwDcDM4PQMcGXhAh9hTGmCnOW7KA-4ZTEWlG--53jWGGseugghEXLEiH1PupRTIlIBO6j8Qhq8IUrTVmHqMqjx8YsXb1ap1OXQ-TK6L7xwZXzaFIVED1BcDNY409Xv0YjKNrCmUO0l5tlgKNNHKCX25vn4SSePozvhtfT2DLJ65hKm4lMCJ4nYBXkikkDQlhr8kQaq3nGFLc5NRpbCYTyTAnJiFGYgp6RhA3QeTf33VcfDYQ6LVywsFyaEqompAnnQkml-f-SMSkwp7KVZ3_komp82a6RUkYFZorpFl10yPoqBA95-u5dYfwqJThdfyHdfqG1p5uBTVbAbCt_zt6Ckw68GT8H_wu6_i8enoir</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Wetzels, R.B.</creator><creator>Zuidema, S.U.</creator><creator>de Jonghe, J.F.M.</creator><creator>Verhey, F.R.J.</creator><creator>Koopmans, R.T.C.M.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>88J</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M2R</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>Determinants of Quality of Life in Nursing Home Residents with Dementia</title><author>Wetzels, R.B. ; Zuidema, S.U. ; de Jonghe, J.F.M. ; Verhey, F.R.J. ; Koopmans, R.T.C.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-26cb5b554f7ec8ef836ae55ccaf76ac94b384cf2a90c6e124b85631a802e9d173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Activities of Daily Living</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cross-Sectional Studies</topic><topic>Data Interpretation, Statistical</topic><topic>Dementia</topic><topic>Dementia - psychology</topic><topic>Drug Utilization</topic><topic>Female</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Marital Status</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Nursing Homes</topic><topic>Original Research Article</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychomotor Agitation - complications</topic><topic>Psychomotor Agitation - psychology</topic><topic>Psychotropic Drugs - therapeutic use</topic><topic>Quality of Life</topic><topic>Regression Analysis</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wetzels, R.B.</creatorcontrib><creatorcontrib>Zuidema, S.U.</creatorcontrib><creatorcontrib>de Jonghe, J.F.M.</creatorcontrib><creatorcontrib>Verhey, F.R.J.</creatorcontrib><creatorcontrib>Koopmans, R.T.C.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Dementia and geriatric cognitive disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wetzels, R.B.</au><au>Zuidema, S.U.</au><au>de Jonghe, J.F.M.</au><au>Verhey, F.R.J.</au><au>Koopmans, R.T.C.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of Quality of Life in Nursing Home Residents with Dementia</atitle><jtitle>Dementia and geriatric cognitive disorders</jtitle><addtitle>Dement Geriatr Cogn Disord</addtitle><date>2010-04</date><risdate>2010</risdate><volume>29</volume><issue>3</issue><spage>189</spage><epage>197</epage><pages>189-197</pages><issn>1420-8008</issn><eissn>1421-9824</eissn><coden>DGCDFX</coden><abstract>Aims: The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. Methods: This cross-sectional observational study included 288 individuals with dementia who reside in 14 special care units in 9 nursing homes. The following measures were used: the Qualidem scale to assess QoL, the Neuropsychiatric Inventory-Nursing Home version, the Global Deterioration Scale (GDS), the Severe Impairment Battery-short version, an Activities of Daily Living scale and PDU. Associations between QoL and NPS were examined using multivariate linear regression models with corrections for potential covariates. Results: The average age of the residents was 84 years (SD = ±7). Agitation, depression, psychosis, psychomotor agitation and psychotropic drugs were independently associated with poor QoL. In patients with mild to moderately severe dementia (GDS 4–6), NPS, PDU and cognitive impairment explained almost half of the variance in QoL scores. Agitation and depression were particularly strong predictors of poor QoL. In patients with severe dementia (GDS 7), agitation, depression, psychosis and cognitive impairment were associated with poor QoL. Conclusions: NPS, cognition and PDU independently impair QoL for patients in both the moderate and advanced stages of dementia. These results challenge existing pharmacological intervention strategies and highlight the need for psychosocial interventions in the treatment of NPS.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>20215750</pmid><doi>10.1159/000280437</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1420-8008 |
| ispartof | Dementia and geriatric cognitive disorders, 2010-04, Vol.29 (3), p.189-197 |
| issn | 1420-8008 1421-9824 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733650426 |
| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Activities of Daily Living Age Factors Aged Aged, 80 and over Cross-Sectional Studies Data Interpretation, Statistical Dementia Dementia - psychology Drug Utilization Female Humans Length of Stay Male Marital Status Middle Aged Neuropsychological Tests Nursing Homes Original Research Article Psychiatric Status Rating Scales Psychomotor Agitation - complications Psychomotor Agitation - psychology Psychotropic Drugs - therapeutic use Quality of Life Regression Analysis Sex Factors |
| title | Determinants of Quality of Life in Nursing Home Residents with Dementia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T03%3A16%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determinants%20of%20Quality%20of%20Life%20in%20Nursing%20Home%20Residents%20with%20Dementia&rft.jtitle=Dementia%20and%20geriatric%20cognitive%20disorders&rft.au=Wetzels,%20R.B.&rft.date=2010-04&rft.volume=29&rft.issue=3&rft.spage=189&rft.epage=197&rft.pages=189-197&rft.issn=1420-8008&rft.eissn=1421-9824&rft.coden=DGCDFX&rft_id=info:doi/10.1159/000280437&rft_dat=%3Cproquest_pubme%3E2012983151%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=232503839&rft_id=info:pmid/20215750&rfr_iscdi=true |