Congenital Cardiac Defects in Neonatal Foals: 18 Cases (1992–2007)
Background: Literature available regarding congenital cardiac defects in foals is limited to reports of individual cases or small case series. Objective: To describe the clinical, echocardiographic, and necropsy findings and breed predilection of congenital cardiac defects in neonatal foals. Animals...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2010, Vol.24 (1), p.206-212 |
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| creator | Hall, T.L Magdesian, K.G Kittleson, M.D |
| description | Background: Literature available regarding congenital cardiac defects in foals is limited to reports of individual cases or small case series.
Objective: To describe the clinical, echocardiographic, and necropsy findings and breed predilection of congenital cardiac defects in neonatal foals.
Animals: Eighteen foals |
| doi_str_mv | 10.1111/j.1939-1676.2009.0445.x |
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| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_proquest_miscellaneous_733645970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733645970</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5425-1955e5e2c958705d59552c2725da51c060e6f946186582c69409867db855afc53</originalsourceid><addsrcrecordid>eNqNkM9u1DAQhy0EokvhFWhuwCFhbGf8B3FBW7ptWcqhFCQuI9dxqizZpMS7YnvjHXhDngRHKXvGF3s8329G-hg74lDwdF6vCm6lzbnSqhAAtoCyxGL3gM32_w_ZDIzluVIlHLAnMa4ABCLqx-xAgLRcSTNjx_O-uwlds3FtNndD1TifHYc6-E3Mmi67CH3nxt5J79r4JuMmUTHE7CW3Vvz59Tst16-eskd1aodn9_chuzp5_3l-mi8_Lc7m75a5x1Jgzi1iwCC8RaMBK0y18EILrBxyDwqCqm2puFFohFe2BGuUrq4Noqs9ykP2Ypp7O_Q_tiFuaN1EH9rWdaHfRtJSqhKthkTqifRDH-MQarodmrUb7ogDjQZpRaMpGk3RaJBGg7RLyef3O7bX61Dtc_-UJeDtBPxs2nD3v3Pp_MvZx_RK8XyKN3ETdvu4G76T0lIjfb1Y0PlycflhYU7pW-KPJr52PbmboYl0dSmAS-CmVGiF_AtFI5L4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733645970</pqid></control><display><type>article</type><title>Congenital Cardiac Defects in Neonatal Foals: 18 Cases (1992–2007)</title><source>Wiley Online Library Open Access</source><creator>Hall, T.L ; Magdesian, K.G ; Kittleson, M.D</creator><creatorcontrib>Hall, T.L ; Magdesian, K.G ; Kittleson, M.D</creatorcontrib><description>Background: Literature available regarding congenital cardiac defects in foals is limited to reports of individual cases or small case series.
Objective: To describe the clinical, echocardiographic, and necropsy findings and breed predilection of congenital cardiac defects in neonatal foals.
Animals: Eighteen foals <15 days of age with 1 or more congenital cardiac defects.
Methods: Medical records of foals diagnosed with congenital cardiac defects at the William R. Pritchard Veterinary Medical Teaching Hospital were reviewed. Data collected included history, signalment, clinical signs, laboratory data, diagnostic and necropsy results, and outcome.
Results: Arabian foals represented 39% of cases with congenital cardiac defects and were significantly (P= .004) overrepresented (OR = 4.7 [CI: 1.8–12.4]) compared with the general hospital population. Ventricular septal defect (VSD) (14/18), tetralogy of Fallot (5/18), and tricuspid valve atresia (4/18) were the most common defects identified. A ≥3/6 heart murmur (14/14) accompanied by tachycardia (14/17), tachypnea (17/17), and cyanosis of mucous membranes (7/16) were the most common clinical signs. Concurrent congenital defects were common (9/18). Two foals, both with VSD, survived for ≥ 8 years after diagnosis and 1 was a successful performance horse.
Conclusions and Clinical Relevance: Arabian horses appear to have a predisposition for cardiac defects. The presence of a loud murmur (≥ 3/6), cyanotic membranes, and tachycardia or tachypnea in a neonatal foal should warrant thorough evaluation of the heart for congenital defects. Foals with cardiac defects should be closely evaluated for concurrent congenital defects in other body systems.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/j.1939-1676.2009.0445.x</identifier><identifier>PMID: 20391638</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>animal pathology ; Animals ; Animals, Newborn ; breed differences ; Cardiology ; Congenital ; congenital abnormalities ; Echocardiography ; Female ; foals ; Genetic Predisposition to Disease ; heart ; Heart Defects, Congenital - genetics ; Heart Defects, Congenital - pathology ; Heart Defects, Congenital - veterinary ; heart diseases ; heart murmus ; Horse ; horse breeds ; horse diseases ; Horse Diseases - congenital ; Horse Diseases - genetics ; Horses ; Male ; Myocardium - pathology ; necropsy ; Retrospective Studies ; signs and symptoms (animals and humans) ; tachycardia ; tachypnea ; tetralogy of Fallot ; tricuspid valve atresia ; ventricular septal defect</subject><ispartof>Journal of veterinary internal medicine, 2010, Vol.24 (1), p.206-212</ispartof><rights>Copyright © 2010 by the American College of Veterinary Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5425-1955e5e2c958705d59552c2725da51c060e6f946186582c69409867db855afc53</citedby><cites>FETCH-LOGICAL-c5425-1955e5e2c958705d59552c2725da51c060e6f946186582c69409867db855afc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1939-1676.2009.0445.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1939-1676.2009.0445.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,11562,27923,27924,27925,45574,45575,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1939-1676.2009.0445.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20391638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hall, T.L</creatorcontrib><creatorcontrib>Magdesian, K.G</creatorcontrib><creatorcontrib>Kittleson, M.D</creatorcontrib><title>Congenital Cardiac Defects in Neonatal Foals: 18 Cases (1992–2007)</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background: Literature available regarding congenital cardiac defects in foals is limited to reports of individual cases or small case series.
Objective: To describe the clinical, echocardiographic, and necropsy findings and breed predilection of congenital cardiac defects in neonatal foals.
Animals: Eighteen foals <15 days of age with 1 or more congenital cardiac defects.
Methods: Medical records of foals diagnosed with congenital cardiac defects at the William R. Pritchard Veterinary Medical Teaching Hospital were reviewed. Data collected included history, signalment, clinical signs, laboratory data, diagnostic and necropsy results, and outcome.
Results: Arabian foals represented 39% of cases with congenital cardiac defects and were significantly (P= .004) overrepresented (OR = 4.7 [CI: 1.8–12.4]) compared with the general hospital population. Ventricular septal defect (VSD) (14/18), tetralogy of Fallot (5/18), and tricuspid valve atresia (4/18) were the most common defects identified. A ≥3/6 heart murmur (14/14) accompanied by tachycardia (14/17), tachypnea (17/17), and cyanosis of mucous membranes (7/16) were the most common clinical signs. Concurrent congenital defects were common (9/18). Two foals, both with VSD, survived for ≥ 8 years after diagnosis and 1 was a successful performance horse.
Conclusions and Clinical Relevance: Arabian horses appear to have a predisposition for cardiac defects. The presence of a loud murmur (≥ 3/6), cyanotic membranes, and tachycardia or tachypnea in a neonatal foal should warrant thorough evaluation of the heart for congenital defects. Foals with cardiac defects should be closely evaluated for concurrent congenital defects in other body systems.</description><subject>animal pathology</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>breed differences</subject><subject>Cardiology</subject><subject>Congenital</subject><subject>congenital abnormalities</subject><subject>Echocardiography</subject><subject>Female</subject><subject>foals</subject><subject>Genetic Predisposition to Disease</subject><subject>heart</subject><subject>Heart Defects, Congenital - genetics</subject><subject>Heart Defects, Congenital - pathology</subject><subject>Heart Defects, Congenital - veterinary</subject><subject>heart diseases</subject><subject>heart murmus</subject><subject>Horse</subject><subject>horse breeds</subject><subject>horse diseases</subject><subject>Horse Diseases - congenital</subject><subject>Horse Diseases - genetics</subject><subject>Horses</subject><subject>Male</subject><subject>Myocardium - pathology</subject><subject>necropsy</subject><subject>Retrospective Studies</subject><subject>signs and symptoms (animals and humans)</subject><subject>tachycardia</subject><subject>tachypnea</subject><subject>tetralogy of Fallot</subject><subject>tricuspid valve atresia</subject><subject>ventricular septal defect</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9u1DAQhy0EokvhFWhuwCFhbGf8B3FBW7ptWcqhFCQuI9dxqizZpMS7YnvjHXhDngRHKXvGF3s8329G-hg74lDwdF6vCm6lzbnSqhAAtoCyxGL3gM32_w_ZDIzluVIlHLAnMa4ABCLqx-xAgLRcSTNjx_O-uwlds3FtNndD1TifHYc6-E3Mmi67CH3nxt5J79r4JuMmUTHE7CW3Vvz59Tst16-eskd1aodn9_chuzp5_3l-mi8_Lc7m75a5x1Jgzi1iwCC8RaMBK0y18EILrBxyDwqCqm2puFFohFe2BGuUrq4Noqs9ykP2Ypp7O_Q_tiFuaN1EH9rWdaHfRtJSqhKthkTqifRDH-MQarodmrUb7ogDjQZpRaMpGk3RaJBGg7RLyef3O7bX61Dtc_-UJeDtBPxs2nD3v3Pp_MvZx_RK8XyKN3ETdvu4G76T0lIjfb1Y0PlycflhYU7pW-KPJr52PbmboYl0dSmAS-CmVGiF_AtFI5L4</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Hall, T.L</creator><creator>Magdesian, K.G</creator><creator>Kittleson, M.D</creator><general>Blackwell Publishing Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Congenital Cardiac Defects in Neonatal Foals: 18 Cases (1992–2007)</title><author>Hall, T.L ; Magdesian, K.G ; Kittleson, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5425-1955e5e2c958705d59552c2725da51c060e6f946186582c69409867db855afc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>animal pathology</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>breed differences</topic><topic>Cardiology</topic><topic>Congenital</topic><topic>congenital abnormalities</topic><topic>Echocardiography</topic><topic>Female</topic><topic>foals</topic><topic>Genetic Predisposition to Disease</topic><topic>heart</topic><topic>Heart Defects, Congenital - genetics</topic><topic>Heart Defects, Congenital - pathology</topic><topic>Heart Defects, Congenital - veterinary</topic><topic>heart diseases</topic><topic>heart murmus</topic><topic>Horse</topic><topic>horse breeds</topic><topic>horse diseases</topic><topic>Horse Diseases - congenital</topic><topic>Horse Diseases - genetics</topic><topic>Horses</topic><topic>Male</topic><topic>Myocardium - pathology</topic><topic>necropsy</topic><topic>Retrospective Studies</topic><topic>signs and symptoms (animals and humans)</topic><topic>tachycardia</topic><topic>tachypnea</topic><topic>tetralogy of Fallot</topic><topic>tricuspid valve atresia</topic><topic>ventricular septal defect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hall, T.L</creatorcontrib><creatorcontrib>Magdesian, K.G</creatorcontrib><creatorcontrib>Kittleson, M.D</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hall, T.L</au><au>Magdesian, K.G</au><au>Kittleson, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Congenital Cardiac Defects in Neonatal Foals: 18 Cases (1992–2007)</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2010</date><risdate>2010</risdate><volume>24</volume><issue>1</issue><spage>206</spage><epage>212</epage><pages>206-212</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background: Literature available regarding congenital cardiac defects in foals is limited to reports of individual cases or small case series.
Objective: To describe the clinical, echocardiographic, and necropsy findings and breed predilection of congenital cardiac defects in neonatal foals.
Animals: Eighteen foals <15 days of age with 1 or more congenital cardiac defects.
Methods: Medical records of foals diagnosed with congenital cardiac defects at the William R. Pritchard Veterinary Medical Teaching Hospital were reviewed. Data collected included history, signalment, clinical signs, laboratory data, diagnostic and necropsy results, and outcome.
Results: Arabian foals represented 39% of cases with congenital cardiac defects and were significantly (P= .004) overrepresented (OR = 4.7 [CI: 1.8–12.4]) compared with the general hospital population. Ventricular septal defect (VSD) (14/18), tetralogy of Fallot (5/18), and tricuspid valve atresia (4/18) were the most common defects identified. A ≥3/6 heart murmur (14/14) accompanied by tachycardia (14/17), tachypnea (17/17), and cyanosis of mucous membranes (7/16) were the most common clinical signs. Concurrent congenital defects were common (9/18). Two foals, both with VSD, survived for ≥ 8 years after diagnosis and 1 was a successful performance horse.
Conclusions and Clinical Relevance: Arabian horses appear to have a predisposition for cardiac defects. The presence of a loud murmur (≥ 3/6), cyanotic membranes, and tachycardia or tachypnea in a neonatal foal should warrant thorough evaluation of the heart for congenital defects. Foals with cardiac defects should be closely evaluated for concurrent congenital defects in other body systems.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>20391638</pmid><doi>10.1111/j.1939-1676.2009.0445.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of veterinary internal medicine, 2010, Vol.24 (1), p.206-212 |
| issn | 0891-6640 1939-1676 |
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| subjects | animal pathology Animals Animals, Newborn breed differences Cardiology Congenital congenital abnormalities Echocardiography Female foals Genetic Predisposition to Disease heart Heart Defects, Congenital - genetics Heart Defects, Congenital - pathology Heart Defects, Congenital - veterinary heart diseases heart murmus Horse horse breeds horse diseases Horse Diseases - congenital Horse Diseases - genetics Horses Male Myocardium - pathology necropsy Retrospective Studies signs and symptoms (animals and humans) tachycardia tachypnea tetralogy of Fallot tricuspid valve atresia ventricular septal defect |
| title | Congenital Cardiac Defects in Neonatal Foals: 18 Cases (1992–2007) |
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